CaV1.3 - Characterization of CaV1.3 on Nanion's SyncroPatch 96

   SyncroPatch 96 (a predecessor model of the SyncroPatch 384PE) application note:     (0.5 MB)

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Summary:

HEK-cells expressing Ca_V1.3 channels were investigated with the SyncroPatch 96. Ca_V1.3 is an L-type, high voltage activated (HVA) calcium channel found in certain neuronal dendrites. Four L-type voltage gated Ca2+ channels (LTCC) isoforms are known (Ca_V1.1, Ca_V1.2, Ca_V1.3, and Ca_V1.4). All of them are characterized by high sensitivity to dihydropyridine (DHP) Ca²⁺ channel modulators, although differences in their voltage-dependence of DHP block exist. Furthermore, they own different biophysical and pharmacological properties and different cellular distribution. The unique DHP sensitivity distinguishes them from other voltage-gated Ca²⁺ channel types. Gating differences are intrinsic properties of their pore-forming a-1 subunits which assemble with accessory a-2-d and b-subunits (in some tissues also a g-subunit) to form a functional channel.

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