NaV1.8 - Block by Tetracaine

Tet traces Conc responseicon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) data and applications:
Cells were kindly provided by Millipore.

A Raw traces from an exemplar cell recorded on the SyncroPatch 96 showing inhibition of current by increasing concentrations of tetracaine. Shown are current responses to a single step protocol to 20 mV for 25 ms from a holding potential of -120 mV.
B Average concentration response curve for tetracaine, IC50 = 71 ± 5 μM (n = 40).

 

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