2001 - Microstructured glass chip for ion channel electrophysiology

icon pap  Port-a-Patch publication in Physical review. E, Statistical, nonlinear, and soft matter physics (2001)

Authors: 
Fertig N., Meyer C., Blick R.H., Trautmann C., Behrends J.C.

Journal: 
Physical Review E, 2001, 64, 040901 R.


Abstract: 

We present a technique by which it is possible to produce a planar sensor for ion channel electrophysiology from glass substrates. Apertures with diameters in the low micrometer to submicrometer range are achieved by irradiation of a glass chip with a single heavy ion and subsequent wet track etching. The function of the device is demonstrated by recordings of single channel currents mediated by the model ion channel gramicidin A in lipid bilayers spanning the micromachined aperture.


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