2001 - Microstructured glass chip for ion channel electrophysiology
Port-a-Patch publication in Physical review. E, Statistical, nonlinear, and soft matter physics (2001)
Fertig N., Meyer C., Blick R.H., Trautmann C., Behrends J.C.
Physical Review E, 2001, 64, 040901 R.
We present a technique by which it is possible to produce a planar sensor for ion channel electrophysiology from glass substrates. Apertures with diameters in the low micrometer to submicrometer range are achieved by irradiation of a glass chip with a single heavy ion and subsequent wet track etching. The function of the device is demonstrated by recordings of single channel currents mediated by the model ion channel gramicidin A in lipid bilayers spanning the micromachined aperture.