The transporters of the SMR family catalyze multidrug and toxin efflux in bacteria, energetically driven by proton influx. Not only are these proteins interesting in the context of novel antimicrobial strategies but due to their small size, they are valuable tools for a better understanding of transport mechanisms and substrate specificity.
In the first session of the transporter webinar series, we have the opportunity to learn from two experts in the field, Randy Stockbridge and Katherine Henzler-Wildman, about their approaches and insights working with this transporter family.
Uncovering the substrates and mechanism of a transporter or demonstrating the functionality of a mutant or variant is a crucial aspect of comprehensive transporter research. In session three of the Transporter Webinar Series Olga Boudker talks about structural studies on a glutamate transporter and how SSM-based electrophysiology supported her work. From Lars Jeuken we hear about the electrophysiological characterization of a metal transporter.
Na/H exchangers are a important and diverse family of secondary active transporters. These proteins are crucial in pH, sodium and volume homeostasis, dysfunction is critical in eukaryotes and procaryotes alike. In the final session of the Transporter Webinar Series David Drew and Matthias Quick share some of their research on the structure and function of this transporter family.