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Research Ins]i[ghts: Nanion’s Transporter Webinar Series 2021

Join us over the course of a year as we dive into a series of 5 sessions (a collective total of 10 scientific presentations/talks; representing academia & industry alike) scheduled across 2021. Whether you join us from an academic or industry setting, we invite you to join us a cross the course of the year to dive deep into all things transporters. Our aim is to provide a unique platform for researchers globally to share their work and engage in meaningful active discussions. All talks will be live and accessible on-demand upon completion of the scheduled event.

18.03.2021 - Understanding drug efflux – Small Multidrug Resistance Family - Stoichiometry and Specificity

Session Abstract: 

The transporters of the SMR family catalyze multidrug and toxin efflux in bacteria, energetically driven by proton influx. Not only are these proteins interesting in the context of novel antimicrobial strategies but due to their small size, they are valuable tools for a better understanding of transport mechanisms and substrate specificity.

In the first session of the transporter webinar series, we have the opportunity to learn from two experts in the field, Randy Stockbridge and Katherine Henzler-Wildman, about their approaches and insights working with this transporter family.

01.07.2021 - SSM-electrophysiology as a Tool for Uncovering Transporter Function

Session Abstract: 

Uncovering the substrates and mechanism of a transporter or demonstrating the functionality of a mutant or variant is a crucial aspect of comprehensive transporter research. In session three of the Transporter Webinar Series Olga Boudker talks about structural studies on a glutamate transporter and how SSM-based electrophysiology supported her work. From Lars Jeuken we hear about the electrophysiological characterization of a metal transporter.

04.11.2021 - Structure and Function of Na+ and H+ dependent transporters

Session Abstract: 

Na/H exchangers are a important and diverse family of secondary active transporters. These proteins are crucial in pH, sodium and volume homeostasis, dysfunction is critical in eukaryotes and procaryotes alike. In the final session of the Transporter Webinar Series David Drew and Matthias Quick share some of their research on the structure and function of this transporter family.  

06.05.2021 - Secondary transport inhibition and regulation by SSM-electrophysiology

Session Abstract: 

Secondary active transporters utilize existing concentration gradients in cells for the uphill transport of molecules. As the coupled substrates are typically ions, mostly sodium or protons, many of these transporters are electrogenic. Their characteristics can be investigated using electrophysiological techniques like SSM-based electrophysiology. In the second session of the Transporter Webinar Series we meet Christine Ziegler and Camilo Perez, who share their stories about using this technology to investigate inhibition and regulation of secondary active transporters.

30.09.2021 - Transporters in Drug Screening and Toxicity Testing

Session Abstract: 

Transport proteins and pumps are getting more established as drug targets. However, the set of available technologies for screening and hit validation is lean. In session four of the Transporter Webinar Series we hear from experts in the pharma field how SSM-based electrophysiology can support transporter drug screening as a potent tool.

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