220908 nanion 1026x196 02Research Ins]i[ghts: Nanion’s Transporter Webinar Series 2022

Join us over the course of a year as we dive into a series of 3 sessions (a collection of scientific presentations/talks; representing academia & industry alike) scheduled across 2022. Whether you join us from an academic or industry setting, we invite you to join us a cross the course of the year to dive deep into all things transporters. Our aim is to provide a unique platform for researchers globally to share their work and engage in meaningful active discussions. All talks will be live and accessible on-demand upon completion of the scheduled event.

23.09.2022 - Functional characterization and substrate binding kinetics of the Na+ cotransporters SGLT1 and GAT1

Session Abstract: 

In eucaryotes, sodium gradients are a common energy source to drive the uptake of a large variety of substrates. In the second session of our Transporter Webinar Series 2022, Andre Bazzone and Rocco Zerlotti will present new insights to Na+ dependent substrate translocation pathways. Studies on the sugar transporter SGLT1 and the neurotransmitter transporter GAT1 revealed detailed kinetic information from substrate induced, electrogenic pre steady-state reactions.


Title: Sugar binding and translocation in SGLT1: SSM-based electrophysiology reveals sugar occluded intermediates

Andre Bazzone, Senior Scientist
(Nanion Technologies, Germany)


Title: Individual charge translocations upon GABA, Na+ and Cl- binding to human GAT-1 indicate conformational flexibility

Rocco Zerlotti, Ph.D. Student
(Nanion Technologies, Germany)


Watch On-Demand Here

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