200829 blog image eBook draft image

In this eBook you will learn:

  • An Introduction into the Patch Clamp Technique
    (a review of past and present technological advances)
  • Significance within Ion Channel Research as it relates to Drug Discovery
  • Current and Future Applications
    (this ebook contains featured Application Notes across multiple targets) 
  • Featured Publications that highlight the Advances and Significance for Drug Discovery
    (amongst academia and industry)

Systems at a Glance

SyncroPatch 384i
SyncroPatch 384i 
High throughput automated patch clamp

Patchliner Thumbnail Ion Diseasese LP
Patchliner 
4/8 channel automated patch clamp

Port a Patch Thumbnail Ion Diseasese LP
Port-a-Patch 
The world's smallest patch clamp rig (supporting giga-seal recordings)



Publications

2020 - VU0606170, a Selective Slack Channels Inhibitor, Decreases Calcium Oscillations in Cultured Cortical Neurons

icon sp96  SyncroPatch 768 PE publication in ACS Chemical Neuroscience (2020)

Authors:
Spitznagel B.D., Mishra N.M., Qunies A.M., Prael F.J., Du Y., Kozek K.A., Lazarenko R.M., Denton J.S., Emmitte K.A., Weaver C.D.

2020 - Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk

 icon sp96 SyncroPatch 384 (a predecessor model of the SyncroPatch 768i instrument) publication in Cell Stem Medicine (2020)

Authors:
Davies M.R., Martinec M., Walls R., Schwarz R., Mirams G.R., Wang K., Steiner G., Surinach A., Flores C., Lave T., Singer T., Polonchuk L.

2020 - Trends in the Development of Diagnostic Tools for Red Blood Cell-Related Diseases and Anemias

 icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument) publication in Frontiers in Physiology (2020)

Authors:
Kaestner L., Bianchi P.

2020 - Striatal Kir2 K+ channel inhibition mediates the antidyskinetic effects of amantadine

 icon sp96   SyncroPatch 768PE (a predecessor model of the SyncroPatch 768i instrument) publication in The Journal of Clinical Investigation (2020)

Authors:
Shen W., Ren W., Zhai S., Yang B., Vanoye C.G., Mitra A., George AL. Jr., Surmeier D.J.

2020 - Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment

icon pl   Patchliner and   icon sp96   SyncroPatch 384i (SyncroPatch 384PEa predecessor model) publication in the Journal of Pharmacological and Toxicological Methods (2020)

Authors:
Brinkwirth N., Takasuna K., Masafumi D., Becker N., Obergrussberger A., Friis S., Furukawa Y., Hasegawa Y., Oka T., Ohtsuki A., Fertig N., Stoelzle-Feix S.

2020 - Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity

icon pl Patchliner and  icon sp96 SyncroPatch 768PE (a predecessor model of the SyncroPatch 768i instrument) publication in Cell Stem Cell (2020)

Authors:
McKeithan W. L., Feyen D.A.M., Bruyneel A.A.N., Okolotowicz K.J., Ryan D.A., Sampson K.J., Potet F., Savchenko A., Gómez-Galeno J., Vu M., Serrano R., George Jr. A.L., Kass R.S., Cashman J.R., Mercola M.

2020 - Novel Expression of GABAA Receptors on Resistance Arteries That Modulate Myogenic Tone

icon sp96   SyncroPatch 96 (a predecessor model of the SyncroPatch 384i) Publication in Journal of Vascular Research (2020)

Authors:
Yim P.D., Gallos G., Lee-Kong S.A., Dan W., Wu A.D., Xu D., Berkowitz D.E., Emala C.W.

2020 - Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization

 icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument) pre-publication in bioRxiv (2020)

Authors:
Matsumura K., Shimomura T., Kubo Y., Oka T., Kobayashi N., Imai S., Yanase N., Akimoto M., Fukuda M., Yokogawa M., Ikeda K., Kurita J., Nishimura Y., Shimada I., Osawa M.

2020 - Mechanism and site of action of big dynorphin on ASIC1a

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) Publication in PNAS (2020)

Authors:
Borg C.B., Braun N., Heusser S.A., Bay Y., Weis D., Galleano I., Lund C., Tian W., Haugaard-Kedström L.M., Bennett E.P., Lynagh T., Strømgaard K., Andersen J., Pless S.A.

2020 - Ion Channels and Relevant Drug Screening Approaches

icon sp96   SyncroPatch 384i editorial found in SLAS Discovery (2020)

Authors:
McGivern, J.G., Ding M.

2020 - High-throughput reclassification of SCN5A variants

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) Publication in The American Journal of Human Genetics (2020)

Authors:
Glazer A.M., Wada Y., Li B., Muhammad A., Kalash O.R., O’Neill M.J., Shields T., Hall L., Short L., Blair M.A., Kroncke B.M., Capra J.A., Roden D.M

2020 - High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KCNH2: Deep mutational scan of KCNH2 trafficking

 icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument) Pre-publication in bioRxiv Biology (2020)

Authors:
Kozek K.A., Glazer A.M., Ng C.-A., Blackwell D., Egly C.L., Vanags L.R., Blair M., Mitchell D., Matreyek K.A., Fowler D.M., Knollmann B.C., Vandenberg J., Roden D.M., Kroncke B.M.

2020 - GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell-derived Cardiomyocytes

icon sp96  SyncroPatch 768PE (a predecessor model of the SyncroPatch 768i) pre-publication in bioRxiv (2020)

Authors:
Potet F., Egecioglu D.E., Burridge P.W.,George A.L. Jr.

2020 - Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist

icon sp96  SyncroPatch 768PE (a predecessor model of the SyncroPatch 768i instrument) publication in Medicinal Chemistry (2020)

Authors:
Scott J.S., Moss T.A., Balazs A., Barlaam B., Breed J., Carbajo R.J., Chiarparin E., Davey P.R.J., Delpuech O., Fawell S., Fisher D.I., Gagrica S., Gangl E.T., Grebe T., Greenwood R.D., Hande S., Hatoum-Mokdad H., Herlihy K., Hughes S., Hunt T.A., Huynh H., Janbon S.L.M., Johnson T., Kavanagh S., Klinowska T., Lawson M., Lister A.S., Marden S., McGinnity D.F., Morrow C.J., Nissink W.M., O'Donovan D.H., Peng B., Polanski R., Stead D.S., Stokes S., Thakur K., Throner S.R., Tucker M.J., Varnes J., Wang H., Wilson D.M., Wu D., Wu Y., Yang B., Yang W.

2020 - Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells

icon pl   Patchliner and   icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument) publication in Nature Scientific Reports (2020)

Authors:
Kramer J., Himmel H.M., Lindqvist A., Stoelzle-Feix S., Chaudhary K.W., Li D., Bohme G.A., Bridgland-Taylor M., Hebeisen S., Fan J., Renganathan M., Imredy J., Humphries E.S.A, Brinkwirth N., Strassmaier T., Ohtsuki A., Danker T., Vanoye C., Polonchuk L., Fermini B., Pierson J.B. & Gintant G.

2020 - Conservation and divergence in NaChBac and NaV1.7 pharmacology reveals novel drug interaction mechanisms

 icon sp96   SyncroPatch 768PE (a predecessor model of the SyncroPatch 768i instrument) publication in Nature Scientific Reports (2020)

Authors:

Zhu W., Li T., Silva J. R., Chen J.

2020 - Computer modeling of whole-cell voltage-clamp analyses to delineate guidelines for good practice of manual and automated patch-clamp

 icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument) pre-publication in BioRxiv (2020)

Authors:
Montnach J., Lorenzini M., Lesage A., Simon I., Nicolas S., Moreau E., Marionneau C., Baró I., De Waard M., Loussouar G.

2020 - Automated Patch Clamp in Drug Discovery: major breakthroughs and innovation in the last decade

 icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument)   icon pl   Patchliner and   icon pap   Port-a-Patch publication in Expert Opinion on Drug Discovery (2020)

Authors:
Obergrussberger A., Friis S., Brüggemann A., Fertig N.

2020 - Application of High-Throughput Automated Patch-Clamp Electrophysiology to Study Voltage-Gated Ion Channel Function in Primary Cortical Cultures

 icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in SLAS Discovery (2020)

Authors:
Toh M.F., Brooks J.M., Strassmaier T., Haedo R.J., Puryear C.B., Roth B.L., Ouk K., Pin S.S.

2020 - Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) publication in Philosophical Transactions of the Royal Society A (2020)

Authors:
Lei, C.L., Clerx, M., Whittaker, D.G., Gavaghan, D.J., de Boer, T.P., Mirams, G.R.

2020 - A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm

icon pl   Patchliner and   icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument) publication in Toxicology and Applied Pharmacology (2020)

Authors:
Ridder B.J., Leishman D.J., Bridgland-Taylor M., Samieegohar M., Han X, Wu W.W., Randolph A., Tran P., Sheng J., Danker T., Lindqvist A., Konrad D., Hebeisen S., Polonchuk L., Gissinger E., Renganathan M., Koci B., Wei H., Fan J., Levesque P., Kwagh J., Imredy J., Zhai J., Rogers M., Humphries E., Kirby R., Stoelzle-Feix S., Brinkwirth N., Rotordam M.G., Becker N., Friis S., Rapedius M., Goetze T.A., Strassmaier T., Okeyo G., Kramer J., Kuryshev Y., Wu C., Himmel H., Mirams G.R., Strauss D.G., Bardenet R., Li Z.

2020 - A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: An illustrative example using the CiPA model

 icon sp96   SyncroPatch 768PE (a predecessor model of the SyncroPatch 768i instrument) publication in the Journal of Pharmacological and Toxicological Methods (2020)

Authors:

Han X., Samieegohar M., Ridder B.J., Wu W.W., Randolph A., Tran P., Sheng J., Stoelzle-Feiz S., Brinkwirth N., Rotordam M.G., Becker N., Friis S., Rapedius M., Goteze T.A., Strassmaier T., Okeyo G., Kramer J., Kuryshev Y., Li Z.

2019 - Synthesis by native chemical ligation and characterization of the scorpion toxin AmmTx3

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Bioorganic & Medicinal Chemistry (2019)

Authors:
Zoukimian C., Meudal H., De Waard S., Ait Quares K., Nicolas S., Canepari M., Béroud R., Landon C., De Waard M., Boturyn D.

2019 - Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Journal of Medicinal Chemistry (2019)

Authors:
McKerrall S.J., Nguyen T., Lai K.W., Bergeron P., Deng L., DiPasquale A., Chang J.H., Chen J., Chernov-Rogan T., Hackos D.H., Maher J., Ortwine D.F., Pang J., Payandeh J., Proctor W.R., Shields S.D., Vogt J., Ji P., Liu W., Ballini E., Schumann L., Tarozzo G., Bankar G., Chowdhury S., Hasan A., Johnson J.P. Jr., Khakh K., Lin S., Cohen C.J., Dehnhardt C.M., Safina B.S., Sutherlin D.P.

2019 - Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Cell (2019)

Authors:
Xu H., Li T., Rohou A., Arthur C.P., Tzakoniati F., Wong E., Estevez A., Kugel C., Franke Y., Chen J., Ciferri C., Hackos D.H., Koth C.M., Payandeh J.

2019 - Spectrum of KV2.1 Dysfunction in KCNB1‐Associated Neurodevelopmental Disorders

icon sp96  SyncroPatch 768PE (a predecessor model of the SyncroPatch 384/768i) Publication Annals of Neurology (2019)

Authors: 
Kang, S.K., Vanoye, C.G., Misra, S.N., Echevarria, D.M., Calhoun, J.D., O’Connor, J.B., Fabre, K.L., McKnight, D., Demmer, L., Goldenberg, P., Grote, L.E., Thiffault, I., Saunders, C., Strauss, K.A., Torkamani, A., van der Smagt, J., van Gassen, K., Carson, R.P., Diaz, J., Leon, E., Jacher, J.E., Hannibal, M.C., Litwin, J., Friedman, N.R., Schreiber, A., Lynch, B., Poduri, A., Marsh, E.D., Goldberg, E.M., Millichap, J.J., George Jr., A.L., Kearney, J.A.

2019 - Role of High‐Throughput Electrophysiology in Drug Discovery

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i),   icon pl   Patchliner and   icon pap   Port-a-Patch review article in Current Protocols in Pharmacology (2019)

Authors:
Liu C., Li T., Chen J.

2019 - Rapid characterisation of hERG channel kinetics II: temperature dependence

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Biophysical Journal (2019)

Authors:
Lei C.L., Clerx M., Beattie K.A., Melgari D., Hancox J.C., Gavaghan D.J., Polonchuk L., Wang K., Mirams G.R.

2019 - Rapid characterisation of hERG channel kinetics I: using an automated high-throughput system

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Biophysical Journal (2019)

Authors:
Lei C.L., Clerx M., Beattie K.A., Gavaghan D.J., Polonchuk L., Mirams G.R., Wang K.

2019 - Predicting Functional Effects of Missense Variants in Voltage-Gated Sodium and Calcium

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) Pre-publication in bioRxiv Biology (2019)

Authors:
Heyne H.O., Baez-Nieto D., Iqbal S., Palmer D., Brunklaus A., Johannesen K.M., Lauxmann S., Lemke J.R., Møller R.S., Pérez-Palma E., Scholl U., Syrbe S., Lerche H., May P., Lal D., Campbell A.J., Pan J., Wang H.-R., Daly M.J.

2019 - Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Cardiovascular Research (2019)

Authors:
Perry M.D., Ng C-A., Mangala M.M., Ng T.Y.M., Hines A.D., Liang W., Xu M.J.O., Hill A.P., Vandenberg J.I.

2019 - In vitro and in vivo characterization of a synthetic scorpion toxin AmmTx3, a potent inhibitor of cardiac voltage-gated potassium channel Kv4.2

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) publication in Archives of Cardiovascular Diseases Supplements (2019)

Authors:
Nicolas S., Zoukimian C.,Meuda H., De Waard S., Ait Ouares K., Canepari M., Beroud R., Landon C., De Waard M., Boturyn D.

2019 - High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Heart Rhythm (2019)

Authors:
Ng C-A., Perry M.D., Liang W., Smith N.J., Foo B., Shrier A., Lukacs G.L., Hill A.P., Vandenberg J.I.

2019 - High Throughput Characterization of KCNB1 Variants Associated with Developmental and Epileptic Encephalopathy

icon sp96  SyncroPatch 768PE (a predecessor model of the SyncroPatch 384/768i) Pre-publication in bioRxiv (2019)

Authors: 
Kang, S.K., Vanoye, C.G., Misra, S.N., Echevarria, D.M., Calhoun, J.D., O’Connor, J.B., Fabre, K.L., McKnight, D., Demmer, L., Goldenberg, P., Grote, L.E., Thiffault, I., Saunders, C., Strauss, K.A., Torkamani, A., van der Smagt, J., van Gassen, K., Carson, R.P., Diaz, J., Leon, E., Jacher, J.E., Hannibal, M.C., Litwin, J., Friedman, N.R., Schreiber, A., Lynch, B., Poduri, A., Marsh, E.D., Goldberg, E.M., Millichap, J.J., George Jr., A.L., Kearney, J.A.

2019 - Functional consequences of a KCNT1 variant associated with status dystonicus and early‐onset infantile encephalopathy

icon sp96   SyncroPatch 384PE (a predeccessor model of the SyncroPatch 384i) publication in Annals of Clinical and Translational Neurology (2019)

Authors:
Gertler T.S., Thompson C.H., Vanoye C.G., Millichap J.J., George Jr A.L.

2019 - Electrophysiological evaluation of pentamidine and 17-AAG in human stem cell-derived cardiomyocytes for safety assessment

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) article in European Journal of Pharmacology (2019)

Authors:
Asahi Y., Nomura F., Abe Y., Doi M., Sakakura T., Takasuna K., Yasuda K.

2019 - Development of Photocrosslinking Probes Based on Huwentoxin-IV to Map the Site of Interaction on Nav1.7

icon sp96  SyncroPatch 768PE (a predecessor model of the SyncroPatch 384/768i) Publication in Cell Chemical Biology (2019)

Authors: 
Tzakoniati F., Xu H., Li T., Garcia N., Kugel C., Payandeh J., Koth C.M., Tate E.W.

2019 - Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) article in Bioorganic and Medicinal Chemistry Letters (2019)

Authors:
Sharma, S.H., Pablo J.L., Montesinos, M.S., Greka, A., Hopkins, C.R.

2019 - Compounds commonly used in equine medicine inhibits the voltage-gated potassium channel Kv11.1

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Research in Veterinary Science (2019)

Authors:
Calloe K., Rognant, S., Friis S., Shaughnessy C., Klaerke D.A., Trachsel D.

2019 - Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1

icon sp96  SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) publication in Toxins (2019)

Authors: 
Nicolas S., Zoukimian C., Bosmans F., Montnach J., Diochot S., Cuypers E., De Waard S., Béroud R., Mebs D., Craik D., Boturyn D., Lazdunski M., Tytgat J., De Waard M.

2019 - Aptamer Efficacies for In Vitro and In Vivo Modulation of αC-Conotoxin PrXA Pharmacology

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Molecules (2019)

Authors:
Taiwe G.S., Montnach J., Nicolas S., De Waard S., Fiore E., Peyrin E., El-Aziz T.M.A., Amar M., Molgó J., Ronjat M., Servent D., Ravelet C., De Waard M.

2019 - A Novel Gain-Of-Function Mutation Of Piezo1 Is Functionally Affirmed In Red Blood Cells By High-Throughput Patch Clamp

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Haematologica (2019)

Authors:
Rotordam G.M., Fermo E., Becker N., Barcellini W., Brüggemann A., Fertig N., Egée S., Rapedius M., Bianchi P., Kaestner L.

2018 - Towards Novel Bioactive Antiperspirants for Cosmetic Applications

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in IFSCC (2018)

Authors:
Ertongur-Fauth T., Fischer S., Hartmann D., Brüggemann A., Seeger V., Kleber A., Krohn M.

2018 - NaV Channels: Assaying Biosynthesis, Trafficking, Function

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) article in The Surfaceome (2018)

Authors:
Tomaselli G.F., Farinelli F.

2018 - Multifocal atrial and ventricular premature contractions with an increased risk of dilated cardiomyopathy caused by a Nav1.5 gain-of-function mutation (G213D)

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) -related publication in International Journal of Cardiology (2018)

Authors:
Calloe K., Broendberg A.K., Christensen A.H., Pedersen L.N., Olesen M.S., de los Angeles Tejada M., Friis S., Thomsen M.B., Bundgaard H., Jensen H.K.

2018 - Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors

icon sp96  SyncroPatch 768PE (a predecessor model of the SyncroPatch 384/768i) publication in PNAS

Authors: 
Chernov-Rogan T., Li T., Lu G., Verschoof H., Khakh K., Jones S.W., Beresini M.H., Liu C., Ortwine D.F., McKerrall S.J., Hackos D.H., Sutherlin D., Cohen C.J., and Chen J.

2018 - High-Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) article in Circulation: Genomic and Precision Medicine (2018)

Authors:
Vanoye C.G., Desai R.R., Fabre K.L., Gallagher S.L., Potet F., DeKeyser J.M., Macaya D., Meiler J, Sanders C.R, and George Jr. A.L.

2018 - Developing High-Throughput Assays to Analyze and Screen Electrophysiological Phenotypes

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) book chapter in Phenotypic Screening (2018)

Authors:
Pan J.Q., Baez-Nieto D., Allen A., Wang HR., Cottrell J.R.

2018 - An update on the advancing high-throughput screening techniques for patch clamp-based ion channel screens: implications for drug discovery

icon sp96   SyncroPatch 384/768PE (a predecessor model of SyncroPatch 384/768i) and   icon pl   Patchliner publication in Expert Opinion on Drug Discovery

Authors: 
Obergrussberger A., Goetze T.A., Brinkwirth N., Becker N., Friis S., Rapedius M., Haarmann C., Rinke-Weiß I., Stölzle-Feix S., Brüggemann A., George M., Fertig N.

2017 - Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

icon sp96  SyncroPatch 768PE (a predecessor model of SyncroPatch 384/768i) publication in Nature Communications (2017)

Authors: 
Chiang E.Y., Li T., Jeet S., Peng I., Zhang J., Lee W. P., DeVoss J., Caplazi P., Chen J., Warming S., Hackos D.H., Mukund S., Koth C.M., Grogan J.L.

2017 - High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE

icon sp96  SyncroPatch 768PE (a predecessor model of SyncroPatch 384/768i) publication in PLoS One (2017)

Authors: 
Li T, Lu G, Chiang E.Y., Chernov-Rogan T., Grogan J.L., Chen J.

2017 - Characterization of a KCNB1 variant associated with autism, intellectual disability, and epilepsy

icon sp96  SyncroPatch 768PE (a predecessor model of SyncroPatch 384/768i) publication in Neurology Genetics (2017)

Authors: 
Calhoun, J.D., Vanoye, C.G., Kok, F., George, A.L., Kearney, J.A.

2017 - Automated Patch Clamp Recordings of Human Stem Cell- Derived Cardiomyocytes.

icon pl  Patchliner and   icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) book chapter in Stem Cell-Derived Models in Toxicology (2017)

Authors: 
Obergrussberger A., Haarmann C., Stölzle-Feix S., Becker N., OhtsukiA., Brüggemann A., George M., Fertig N.

2016 - Use-dependent Block of Human Cardiac Sodium Channels by GS967

icon sp96  SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Molecular Pharmacology (2016)

Authors: 
Potet F., Vanoye C.G., George Jr. A.L.

2016 - pH-sensitive K+ channel TREK-1 is a novel target in pancreatic cancer

icon sp96  SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Biochimica et Biophysica Acta (2016)

Authors: 
Sauter D.R.P., Sørensen C.E., Rapedius M., Brüggemann A., Novak I.

2016 - Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module

icon sp96  SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Journal of Lab Automation (2016)

Authors: 
Obergrussberger A., Brüggemann A., Goetze T.A., Rapedius M., Haarmann C., Rinke I., Becker N., Oka T., Ohtsuki A., Stengel T., Vogel M., Steindl J., Mueller M., Stiehler J., George M., Fertig N.

2015 - Novel screening techniques for ion channel targeting drugs

icon pl  Patchliner,   icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) and   Icon CE   CardioExcyte 96 publication in Channels (2015)

Authors: 
Obergrussberger A., Stölzle-Feix S., Becker N., Brüggemann A., Fertig N., Möller C.

2015 - Electrophysiological analysis of mammalian cells expressing hERG using automated 384-well-patch-clamp

icon sp96  SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in BCM Pharmacology and Toxicology (2015) 

Authors: 
Haraguchi Y., Ohtsuki A., Oka T., Shimizu T.

2014 - New strategies in ion channel screening for drug discovery: are there ways to improve its productivity?

icon sp96  SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Journal of Laboratory Automation (2014)

Authors: 
Farre C., Fertig N.

2014 - Early identification of hERG liability in drug discovery programs by automated patch clamp

icon pl  Patchliner and   icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Frontiers in Pharmacology (2014)

Authors: 
Danker T., Moeller C.

2012 - Natural and artificial ion channels for biosensing platforms

icon pap   Port-a-Patch,   icon pl   Patchliner,   icon sp96   SyncroPatch 96 ((a predecessor model of SyncroPatch 384PE) and   icon vpp   Vesicle Prep Pro publication in Analytical and Bioanalytical Chemistry (2012)

Authors: 
Steller L., Kreir M., Salzer R.

2012 - HTS techniques for patch clamp-based ion channel screening - economy and advances

icon pap   Port-a-Patch,   icon pl   Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) publication in Expert Opinion on Drug Discovery (2012)

Authors: 
Farre C. and Fertig N.

2011 - State-of-the-art automated patch clamp devices: heat activation, action potentials, and high throughput in ion channel screening

icon pap   Port-a-Patch,   icon pl  Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) publication in Frontiers in Pharmacology (2011)

Authors: 
Stoelzle S., Obergrussberger A., Brüggemann A., Haarmann C., George M., Kettenhofen R., Fertig N.

2011 - Automated electrophysiology makes the pace for cardiac ion channel safety screening

icon pl  Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) publication in Frontiers in Pharmacology (2011)

Authors: 
Möller C., Witchel H.

2010 - Renaissance of ion channel research and drug discovery by patch clamp automation

icon pap  Port-a-Patch,   icon pl   Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE)  publication in Future Medical Chemistry (2010)

Authors:
Farre C. and Fertig N.

2020 - Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells

 icon pl Patchliner publication in Cell Communication and Signaling (2020)

Authors:
Bissinger R., Petkova-Kirova P., Mykhailova O., Oldenborg PA., Novikova E., Donkor D.A., Dietz T., Bhuyan A.A.M., Sheffield W.P., Grau M., Artunc F., Kaestner L., Acker J.P., Qadri S.M.

2020 - The electrophysiological effect of cannabidiol on hERG current and in guinea-pig and rabbit cardiac preparations

 icon pl Patchliner publication in Nature Scientific Reports (2020)

Authors:
Orvos P., Pászti B., Topal L., Gazdag P., Prorok J., Polyák A., Kiss T., Tóth-Molnár E., Csupor-Löffler B., Bajtel A., Varró A., Hohmann J., Virág L., Csupor D.

2020 - Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity

icon pl  Patchliner publication in European Journal of Medicinal Chemistry (2020)

Authors: 
Froux L., Elbahnsi A., Boucherle B., Billet A., Baatallah N., Hoffmann B., Alliot J., Zelli R., Zeinyeh W., Haudecoeur R., Chevalier B., Fortuné A., Mirval S., Simard C., Lehn P., Mornon J-P., Hinzpeter A., Becq F., Callebaut I., Décout J-L.

2020 - Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom

icon pl   Patchliner publication in Biochemical Pharmacology (2020)

Authors:
Luna-Ramirez K., Csoti A., McArthur J.R., Chin Y.K.Y., Anangi R., del Carmen Najera R., Possani L.D., King G.F., Panyi G., Yu H., Adams D.J., Finol-Urdaneta R.K.

2020 - Screening Technologies for Inward Rectifier Potassium Channels: Discovery of New Blockers and Activators

icon pl  Patchliner publication in SLAS DISCOVERY (2020)

Author: 
Walsh, K. B.

2020 - Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment

icon pl   Patchliner and   icon sp96   SyncroPatch 384i (SyncroPatch 384PEa predecessor model) publication in the Journal of Pharmacological and Toxicological Methods (2020)

Authors:
Brinkwirth N., Takasuna K., Masafumi D., Becker N., Obergrussberger A., Friis S., Furukawa Y., Hasegawa Y., Oka T., Ohtsuki A., Fertig N., Stoelzle-Feix S.

2020 - Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity

icon pl Patchliner and  icon sp96 SyncroPatch 768PE (a predecessor model of the SyncroPatch 768i instrument) publication in Cell Stem Cell (2020)

Authors:
McKeithan W. L., Feyen D.A.M., Bruyneel A.A.N., Okolotowicz K.J., Ryan D.A., Sampson K.J., Potet F., Savchenko A., Gómez-Galeno J., Vu M., Serrano R., George Jr. A.L., Kass R.S., Cashman J.R., Mercola M.

2020 - Pharmacological and genetic characterisation of the canine P2X4 receptor

icon pl   Patchliner publication in British Journal of Pharmacology (2020)

Authors:
Sophocleous R.A., Berg, T., Finol‐Urdaneta R.K., Sluyter V., Keshiya S., Bell L., Curtis S.J., Curtis B.L., Seavers A., Bartlett R., Dowton M., Stokes L., Ooi L., Sluyter R.

2020 - N-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity

icon pl  Patchliner publication in Cancer Cell International (2020)

Authors: 
Keenan B., Finol-Urdaneta R.K., Hope A., Bremner J.B., Kavallaris M., Lucena-Agell D., Ángela Oliva M., Díaz J.F & Vine K.L.

2020 - Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation

icon sp96  Patchliner publication in Frontiers in Cell and Developmental Biology (2020)

Authors:
Li W., Stauske M., Luo X., Wagner S., Vollrath M., Mehnert C.S., Schubert M., Cyganek L., Chen S., Hasheminasab S.M., Wulf G., El-Armouche A., Maier L.S., Hasenfuss G., Guan K.

2020 - Discovery and Development of SUVN-911: A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression

icon pl  Patchliner publication in Journal of Medicinal Chemistry (2020)

Authors:
Nirogi R., Mohammed A.R., Shinde A.K., Ravella S.R., Bogaraju N., Subramanian R., Mekala V.R., Palacharla R.C., Muddana N., Thentu J.B., Bhyrapuneni G., Abraham R., Jasti V.

2020 - Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells

icon pl   Patchliner and   icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument) publication in Nature Scientific Reports (2020)

Authors:
Kramer J., Himmel H.M., Lindqvist A., Stoelzle-Feix S., Chaudhary K.W., Li D., Bohme G.A., Bridgland-Taylor M., Hebeisen S., Fan J., Renganathan M., Imredy J., Humphries E.S.A, Brinkwirth N., Strassmaier T., Ohtsuki A., Danker T., Vanoye C., Polonchuk L., Fermini B., Pierson J.B. & Gintant G.

2020 - Automated Patch Clamp in Drug Discovery: major breakthroughs and innovation in the last decade

 icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument)   icon pl   Patchliner and   icon pap   Port-a-Patch publication in Expert Opinion on Drug Discovery (2020)

Authors:
Obergrussberger A., Friis S., Brüggemann A., Fertig N.

2020 - Automated Dynamic Clamp for Simulation of IK1 in Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes in Real Time Using Patchliner Dynamite8

icon pl   Patchliner and Dynamite8 publication in Current Protocols in Pharmacology (2020)

Authors:
Becker N., Horváth A., De Boer T., Fabbri A., Grad C., Fertig N., George M., Obergrussberger A.

2020 - Assessment of the Effects of Online Linear Leak Current Compensation at Different Pacing Frequencies in a Dynamic Action Potential Clamp System

icon pl Patchliner publication in Computing in Cardiology (2020)

Authors:
Fabbri A., Prins A., de Boer T.P.

2020 - An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors

icon pl   Patchliner publication in Phytochemistry (2020)

Authors:
Alijevic O., McHugh D., Rufener L., Mazurov A., Hoeng J., Peitsch M.

2020 - A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm

icon pl   Patchliner and   icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument) publication in Toxicology and Applied Pharmacology (2020)

Authors:
Ridder B.J., Leishman D.J., Bridgland-Taylor M., Samieegohar M., Han X, Wu W.W., Randolph A., Tran P., Sheng J., Danker T., Lindqvist A., Konrad D., Hebeisen S., Polonchuk L., Gissinger E., Renganathan M., Koci B., Wei H., Fan J., Levesque P., Kwagh J., Imredy J., Zhai J., Rogers M., Humphries E., Kirby R., Stoelzle-Feix S., Brinkwirth N., Rotordam M.G., Becker N., Friis S., Rapedius M., Goetze T.A., Strassmaier T., Okeyo G., Kramer J., Kuryshev Y., Wu C., Himmel H., Mirams G.R., Strauss D.G., Bardenet R., Li Z.

2020 - A P2RX7 single nucleotide polymorphism haplotype promotes exon 7 and 8 skipping and disrupts receptor function

icon pl   Patchliner publication in The Faseb Journal (2020)

Authors: 
Skarratt K.K., Gu B.J., Lovelace M.D., Milligan C.J., Stokes L., Glover R., Petrou S, Wiley J.S., Fuller S.J.

2020 - A novel pyrazolo [3,4-d] pyrimidine, KKC080106, activates the Nrf2 pathway and protects nigral dopaminergic neurons

icon pl  Patchliner publication in Experimental Neurology (2020)

Authors: 
Lee J.A., Kim H.R., Son H.J., Shin N., Han S.H., Cheong C.S., Kim D.J., Hwanga O.

2019 - Role of High‐Throughput Electrophysiology in Drug Discovery

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i),   icon pl   Patchliner and   icon pap   Port-a-Patch review article in Current Protocols in Pharmacology (2019)

Authors:
Liu C., Li T., Chen J.

2019 - Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias

icon pl   Patchliner publication in Frontiers in Physiology (2019)

Authors:
Petkova-Kirova P., Hertz L., Danielczok J., Huisjes R., Makhro A., Bogdanova A., del Mar Mañú-Pereira M., Vives Corrons J.-L., van Wijk R., Kaestner L.

2019 - MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo

icon pl   Patchliner publication in Cell Stem Cell (2019)

Authors:
Fiedler L.R., Chapman K., Xie M., Maifoshie E., Jenkins M., Golforoush P.A., Bellahcene M., Noseda M., Faust D., Jarvis A., Newton G., Paiva M.A., Harada M., Stuckey D.J., Song W., Habib J., Narasimham P., Aqil R., Schneider M.D.

2019 - Isolation and Pharmacological Investigation of Compounds From Euphorbia matabelensis

icon pl   Patchliner publication in Natural Product Communications (2019)

Authors:
Hammadi R., Kúsz N., Mwangi P.W., Kulmány Á., Zupkó I., Orvos P., Tálosi L., Hohmann J., Vasas A.

2019 - GIRK channel activity of Hungarian mushrooms: From screening to biologically active metabolites

icon pl   Patchliner publication in Fitoterapia (2019)

Authors:
Ványolósa A., Orvos P., Chuluunbaatar B., Tálosi L., Hohmann J.

2019 - GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signalling in a GABA-independent manner

icon pl   Patchliner publication in Gut (2019)

Authors:
Jiang S.H., Zhu L.L., Zhang M., Li R.K., Yang Q., Yan J.Y., Zhang C., Yang J.Y., Dong F.Y., Dai M., Hu L.P., Li J., Li Q., Wang Y.H., Yang X.M., Zhang Y.L., Nie H.Z., Zhu L., Zhang X.L., Tian G.A., Zhang X.X., Cao X.Y., Tao L.Y., Huang S., Jiang Y.S., Hua R., Qian Luo K., Gu J.R., Sun Y.W., Hou S., Zhang Z.G.

2019 - Establishment of an automated patch-clamp platform for electrophysiological and pharmacological evaluation of hiPSC-CMs

icon pl   Patchliner and Dynamite8 publication in Stem Cell Research (2019)

Authors:
Li W., Luo X., Y., Wagner M., Piorkowski C., El-Armouche A., Guan K.

2019 - Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs

icon pl   Patchliner publication in ACS Medicinal Chemistry Letters (2019)

Authors:
Harvey A.J., Avery T.D., Schaeffer L, Joseph C., Huff B.C., Singh R., Morice C., Giethlen B.,Grishin A.A., Coles C.J., Kolesik P., Wagner S., Andriambeloson E., Huyard B., Poiraud E., Paul D., O’Connor S.M.

2019 - Discovery of a small molecule modulator of the Kv1.1/Kvβ1 channel complex that reduces neuronal excitability and in vitro epileptiform activity

icon pl   Patchliner publication in CNS Neuroscience & Therapeutics (2019)

Authors:
Niespodziany I., Mullier B., André V.M., Ghisdal P., Jnoff E., Moreno‐Delgado D., Swinnen D., Sands Z., Wood M., Wolff C.

2019 - Avoiding hERG-liability in drug design via synergetic combinations of different (Q)SAR methodologies and data sources: a case study in an industrial setting

icon pl   Patchliner publication in Journal of Cheminformatics (2019)

Authors:
Hanser T., Steinmetz F.P., Plante J., Rippmann F., and Krier M.

2019 - Automated Planar Patch-Clamp Recording of P2X Receptors

icon pl   Patchliner book chapter in Ion Channels (2020)

Authors: 
Milligan, C. J., Jiang L.H.

2019 - A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

 icon pl   Patchliner publication in Frontiers in Cellular Neuroscience (2019)

Authors:
Ranjan R., Logette E., Marani M., Herzog M., Tâche V., Scantamburlo E., Buchillier V., Markram H.

2018 - Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death

icon pl   Patchliner publication in PNAS (2018)

Authors:
Richards K.L., Milligan C.J., Richardson R.J., Jancovski N., Grunnet M., Jacobson L.H., Undheim E.A.B., Mobli M., Chow C.Y., Herzig V., Csoti A., Panyi G., Reid A.A., King G.F., Petrou S.

2018 - Evaluation of possible proarrhythmic potency: comparison of the effect of dofetilide, cisapride, sotalol, terfenadine and verapamil on hERG and native IKr currents and on cardiac action potential

icon pl   Patchliner publication in Toxicological Sciences (2018)

Authors:
Orvos P., Kohajda Z., Szlovák J., Gazdag P., Árpádffy-Lovas T., Tóth D., Geramipour A., Tálosi L., Jost N., Varró A., Virág L.

2018 - Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity - An in vitro structure-activity analysis

icon pl   Patchliner publication in Toxicology Letters (2018)

Authors:
Scheffel C., Niessen K.V., Rappenglück S., Wanner K.T., Thiermann H., Worek F., Seeger T.

2018 - Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo

icon pl   Patchliner publication in Pharmacological Research (2018)

Authors:
Baburin I., Varkevisser R., Schramm A., Saxena P., Beyl S., Szkokan P., Linder T., Stary-Weinzinger A., van der Heyden M.A.G., Houtman M., Takanari H., Jonsson M., Beekman J.H.D., Hamburger M., Vos M.A., Hering S.

2018 - Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning

icon pl   Patchliner publication in Toxicology Letters (2018)

Authors:
Scheffel C., Niessen K.V., Rappenglück S., Wanner K.T., Thiermann H., Worek F., Seeger T.

2018 - An update on the advancing high-throughput screening techniques for patch clamp-based ion channel screens: implications for drug discovery

icon sp96   SyncroPatch 384/768PE (a predecessor model of SyncroPatch 384/768i) and   icon pl   Patchliner publication in Expert Opinion on Drug Discovery

Authors: 
Obergrussberger A., Goetze T.A., Brinkwirth N., Becker N., Friis S., Rapedius M., Haarmann C., Rinke-Weiß I., Stölzle-Feix S., Brüggemann A., George M., Fertig N.

2018 - A Previously Unrecognized Ca2+-inhibited Nonselective Cation Channel in Red Blood Cells

icon pl   Patchliner publication in HemaSphere (2018)

Authors:
Petkova-Kirova P., Hertz L., Makhro A., Danielczok J., Huisjes R., Llaudet-Planas E., Mañú-Pereira, M., Vives Corrons J.-L., van Wijk R., Bogdanova A., Kaestner L.

2018 - A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of IK1 Ion Channels in Real-Time

icon pl  Patchliner publication in Frontiers in Physiology

Authors: 
Goversen B., Becker., N., Stölzle-Feix S., Obergrussberger A., Vos M.A., van Veen T.A.B., Fertig N., de Boer T.P.

2017 - Trifluoperazine-Induced Suicidal Erythrocyte Death and S-Nitrosylation Inhibition, Reversed by the Nitric Oxide Donor Sodium Nitroprusside

icon pl   Patchliner publication in Cellular Physiology and Biochemistry (2017)

Authors:
Ghashghaeinia M., Wesseling M.C., Ramos E., Petkova-Kirova P., Waibel S., Lang E., Bissinger R., Alzoubi K., Edelmann B., Hosseinzadeh Z., Dreischer P., Shahvaroughi-Farahani A., Mrowietz U., Köberle M., Kaestner L., Bernhardt I., Martínez-Ruiz A., Wieder T., Lang F.

2017 - Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis

icon pl  Patchliner publication in Human Mutation (2017)

Authors: 
Sadovnick A.D., Gu B.J., Traboulsee A.L., Bernales C.Q., Encarnacion M., Yee I.M., Criscuoli M.G., Huang X., Ou A., Milligan C.J., Petrou S, Wiley J.S, Vilariño-Güell C.

2017 - Myoclonus Epilepsy and Ataxia due to KCNC1 Mutation: Analysis of 20 Cases and K+ Channel Properties

icon pl  Patchliner publication in Annals in Neurobiology (2017)

Authors: 
Oliver K.L., Franceschetti S., Milligan C.J., Muona M., Mandelstam S.A., Canafoglia L., Boguszewska-Chachulska A.M., Korczyn A.D.,Bisulli F., Di Bonaventura C., Ragona F., Michelucci R., Ben-Zeev B., Straussberg R., Panzica F., Massano J., Friedman D., Crespel A., Engelsen B.A., Andermann F., Andermann E., Spodar K., Lasek-Bal A., Riguzzi P.,Pasini E., Tinuper P., Licchetta L., Gardella E., Lindenau M., Wulf A., Møller R.S.

2017 - L-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes

icon pl  Patchliner publication in PLoS ONE (2017)

Authors: 
Wu J., Wang X., Chung Y.Y. Koh C.H. Liu Z., Guo H., Yuan Q., Wang C., Su S., Wei H.

2017 - Identification of Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides

icon pl   Patchliner publication in Nature Scientific Reports (2017)

Authors:
Koh C.H., Wu J., Chung Y.Y., Liu Z., Zhang R.R., Chong K., Korzh V., Ting S., Oh S., Shim W., Tian H.Y., Wei H.

2017 - Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease

icon pl  Patchliner publication in PLoS ONE (2017)

Authors: 
Kim T., Yang H.Y., Park B.G., Jung S.Y., Park J.H., Park K.D., Min S.J., Tae J., Yang H., Cho S., Cho S.J., Song H., Mook-Jung I., Lee J., Pae A.N.

2017 - Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function

icon pl  Patchliner publication in Frontiers in Pharmacology (2017)

Authors: 
Billet A.,Froux L., Hanrahan J.W., Becq F.

2017 - Correlation between human ether-a-go-go related gene channel inhibition and action potential prolongation

icon pl   Patchliner publication in British Journal of Pharmacology (2017)

Authors:
Saxena P., Hortigon‐Vinagre M.P., Beyl S.,Baburin I., Andranovits S., Iqbal S.M., Costa A., IJzerman A.P., Kügler P., Timin E., Smith G.L., Hering S.

2017 - Automated Patch Clamp Recordings of Human Stem Cell- Derived Cardiomyocytes.

icon pl  Patchliner and   icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) book chapter in Stem Cell-Derived Models in Toxicology (2017)

Authors: 
Obergrussberger A., Haarmann C., Stölzle-Feix S., Becker N., OhtsukiA., Brüggemann A., George M., Fertig N.

2017 - 14-3-3 proteins regulate K2P5.1 surface expression on T lymphocytes

icon pl  Patchliner publication in Traffic (2017)

Authors:
Fernández-Orth J., Ehling P., Ruck T., Pankratz S., Hofmann M.,Landgraf P., Dieterich D.C., SmallaK.-H., Kähne T., Seebohm G., Budde T., Wiendl H., Bittner S., Meuth S.G.

2017 - 'Gardos Channelopathy': a variant of hereditary Stomatocytosis with complex molecular regulation

icon pl  Patchliner publication in Scientific Reports (2017)

Authors: 
Fermo E., Bogdanova A., etkova-Kirova P., Zaninoni A., Marcello A.P., Makhro A., Hänggi P., Hertz L., Danielczok J., Vercellati C., Mirra N., Zanella A., Cortelezzi A., Barcellini W., Kaestner L., Bianchi P.

2016 - The potassium channels TASK2 and TREK1 regulate functional differentiation of murine skeletal muscle cells

icon pl  Patchliner publication in American Journal of Physiology - Cell Physiology (2016)

Authors: 
Afzali A.M., Ruck T., Herrmann A.M., Iking J., Sommer C., Kleinschnitz C., Preuβe C., Stenzel W., Budde T., Wiendl H., Bittner S., Meuth S.G.

2016 - The antiepileptic medications carbamazepine and phenytoin inhibit native sodium currents in murine osteoblasts

icon pl  Patchliner publication in Epilepsia (2016)

Authors: 
Petty S.J., Milligan C.J., Todaro M., Richards K.L., Kularathna P.K., Pagel C.N., French C.R., Hill-Yardin E.L., O'Brien T.J., Wark J.D., Mackie E.J., Petrou S.

2016 - Myrsinane, Premyrsinane, and Cyclomyrsinane Diterpenes fromEuphorbia falcata as Potassium Ion Channel Inhibitors with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effects

icon pl  Patchliner publication in Journal of Natural Products (2016)

Authors: 
Vasas A., Forgo P., Orvos P., Tálosi L., Csorba A., Pinke G., Hohmann J.

2016 - Human T cells in silico: Modelling their electrophysiological behaviour in health and disease

icon pl  Patchliner publication in Journal of Theoretical Biology (2016)

Authors: 
Ehling P., Meuth P., Eichinger P., Hermann A.M., Bittner S., Pawlowski M., Pankratz S., Herty M., Budde T., Meuth S.G.

2016 - Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations

icon pl  Patchliner publication in Scientific Reports (2016)

Authors: 
Han B., He K., Cai C., Tang Y., Yang L., Heinemann S.H., Hoshi T., Hou S.

2016 - Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation

icon pl  Patchliner publication in Journal of the American College of Cardiology (2016)

Authors:
Lorberbaum T., Sampson K.J., Chang J.B., Iyer V., Woosley R.L., Kass R.S., Tatonetti N.P.

2016 - Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes

icon pl  Patchliner publication in Stem Cells and Development (2016)

Authors: 
Rajamohan D., Kalra S., Hoang M.D., George V., Staniforth A., Russell H., Yang X., Denning C.

2015 - Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy

icon pl  Patchliner publication in Journal of Clinical Medicine (2015)

Authors: 
Friedrichs S., Malan D., Voss Y., Sasse P.

2015 - Novel screening techniques for ion channel targeting drugs

icon pl  Patchliner,   icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) and   Icon CE   CardioExcyte 96 publication in Channels (2015)

Authors: 
Obergrussberger A., Stölzle-Feix S., Becker N., Brüggemann A., Fertig N., Möller C.

2014 - Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy

icon pl  Patchliner publication in Neurobiology of Disease (2014)

Authors: 
Oliva M.K., McGarr T.C., Beyer B.J., Gazina E., Kaplan D.I., Cordeiro L., Thomas E., Dib-Hajj S.D., Waxman S.G., Frankel W.N., Petrou S.

2014 - Multi-Generational Pharmacophore Modeling for Ligands to the Cholane Steroid-Recognition Site in the β1 Modulatory Subunit of the BK(Ca) Channel

icon pl  Patchliner publication in Journal of Molecular Graphics and Modelling (2014)

Authors: 
McMillan J.E., Bukiya A.N., Terrell C.L., Patil S.A., Miller D.D., Dopico A.M., Parrilla A.L.

2014 - Early identification of hERG liability in drug discovery programs by automated patch clamp

icon pl  Patchliner and   icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Frontiers in Pharmacology (2014)

Authors: 
Danker T., Moeller C.

2014 - Automated Patch Clamp Analysis of nAChα7 and NaV1.7 Channels

icon pap  Port-a-Patch and   icon pl   Patchliner publication in Current Protocols in Pharmacology (2014)

Authors: 
Obergrussberger A., Haarmann C., Rinke I., Becker N., Guinot D., Brueggemann A., Stoelzle-Feix S., George M., Fertig N.

2013 - Red cell investigations: Art and artefacts

icon pl  Patchliner publication in Blood reviews (2013)

Authors: 
Minetti G., Egée S., Mörsdorf D., Steffen P., Makhro A., Achilli C., Ciana A., Wang J., Bouyer G., Bernhardt I., Wagner C., Thomas S., Bogdanova A., Kaestner L.

2013 - Minimized cell usage for stem cell-derived and primary cells on an automated patchclamp system

icon pl  Patchliner publication in Journal of Pharmacological and Toxicological Methods (2013)

Authors: 
Becker N., Stoelzle S., Göpel S., Guinot D., Mumm P., Haarmann C., Malan D., Bohlen H., Kossolov E., Kettenhofen R., George M., Fertig N., Brüggemann A.

2013 - Establishment of a Secondary Screening Assay for P/Q-Type Calcium Channel Blockers

icon pl   Patchliner publication in Combinatorial Chemistry & High Throughput Screening (2013)

Authors: 
Hermann D., Mezler M., Swensen A., Bruehl C., Obergrußberger A., Wicke K., Schoemaker H., Gross G., Draguhn A., Nimmrich V.

2013 - Automated Planar Patch Clamp

icon pl   Patchliner book chapter in Ion Channels (2013)

Authors: 
Milligan, C. J., Möller, C.

2012 - TRPA1 Agonist Activity of Probenecid Desensitizes Channel Responses: Consequences for Screening

icon pl   Patchliner publication in ASSAY and Drug Development Technologies (2012)

Authors: 
McClenaghan C., Zeng F., Verkuyl J.M.

2012 - Toward a new gold standard for early safety: automated temperature-controlled hERG test on the Patchliner

icon pl   Patchliner publication in Frontiers in Pharmacology (2012)

Authors: 
Polonchuk L.

2012 - Synthesis and In Vitro Antibacterial Activity of Novel 3‐Azabicyclo [3.3. 0] octanyl Oxazolidinones

icon pl   Patchliner publication in Chemical Biology and Drug Design (2012)

Authors: 
Bhattarai D., Lee S.H., Seo S.H., Nam G., Kang S.B., Pae A.N., Kim E.E., Oh T., Cho S.N., Keum G.

2012 - Observation of Antinociceptive Effects of Oxymatrine and its Effect on Delayed Rectifier K+ Currents (Ik) in PC12 Cells

icon pl   Patchliner publication in Neurochemical Research (2012)

Authors: 
Wang Y., Yuan J., Yuan X., Wang W., Pei X., Zhao Q., Cao H., Xu M., Liu Z.

2012 - Natural and artificial ion channels for biosensing platforms

icon pap   Port-a-Patch,   icon pl   Patchliner,   icon sp96   SyncroPatch 96 ((a predecessor model of SyncroPatch 384PE) and   icon vpp   Vesicle Prep Pro publication in Analytical and Bioanalytical Chemistry (2012)

Authors: 
Steller L., Kreir M., Salzer R.

2012 - HTS techniques for patch clamp-based ion channel screening - economy and advances

icon pap   Port-a-Patch,   icon pl   Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) publication in Expert Opinion on Drug Discovery (2012)

Authors: 
Farre C. and Fertig N.

2012 - Characterizing Human Ion Channels in Induced Pluripotent Stem Cell-Derived Neurons

icon pl   Patchliner publication in Journal of Biomolecular Screening (2012)

Authors: 
Haythornthwaite A, Stoelzle S, Hasler A, Kiss A, Mosbacher J, George M, Brüggemann A, Fertig N.

2011 - State-of-the-art automated patch clamp devices: heat activation, action potentials, and high throughput in ion channel screening

icon pap   Port-a-Patch,   icon pl  Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) publication in Frontiers in Pharmacology (2011)

Authors: 
Stoelzle S., Obergrussberger A., Brüggemann A., Haarmann C., George M., Kettenhofen R., Fertig N.

2011 - Rapid and Contrasting Effects of Rosiglitazone on Transient Receptor Potential TRPM3 and TRPC5 Channels

icon pl  Patchliner publication in Molecular Pharmacology (2011)

Authors: 
Majeed Y., Bahnasi Y., Seymour V.A.L., Wilson L.A., Milligan C.J., Agarwal A.K., Sukumar P., Naylor J., Beech D.J.

2011 - Pharmacological studies of Cav3.1 T-type calcium channels using automated patch-clamp techniques

icon pl  Patchliner publication in General Physiology and Biophysics (2011)

Authors: 
Choi K.-H., Song C., Cheong C.S., Rhim H.

2011 - Development of a selective small-molecule inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel

icon pl  Patchliner publication in Molecular Pharmacology (2011)

Authors: 
Bhave G., Chauder B.A., Liu W., Dawson E.S., Kadakia R., Nguyen T.T., Lewis L.M., Meiler J., Weaver C.D., Satlin L.M., Lindsley C.W., Denton J.S.

2011 - Cardiac Toxicity

icon pl   Patchliner and   icon pap   Port-a-Patch book chapter in ADMET for Medicinal Chemists: A Practical Guide (2011)

Authors: 
Kettenhofen R., Schwengberg S.

2011 - Automated Patch Clamp on mESC-Derived Cardiomyocytes for Cardiotoxicity Prediction

icon pl   Patchliner and   icon pap   Port-a-Patch publication in Journal of Biological Chemistry (2011)

Authors: 
Stoelzle S., Haythornthwaite A., Kettenhofen R., Kolossov E., Bohlen H., George M., Brüggemann A., Fertig N.

2011 - Automated electrophysiology makes the pace for cardiac ion channel safety screening

icon pl  Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) publication in Frontiers in Pharmacology (2011)

Authors: 
Möller C., Witchel H.

2011 - The Chimeric approach reveals that differences in the TRPV1 pore domain determine species-specific sensitivity to block of heat activation

icon pl   Patchliner publication in Journal of Biological Chemistry (2011)

Authors: 
Papakosta M., Dalle C., Haythornthwaite A., Cao L., Stevens E.B., Burgess G., Russell R., Cox P.J., Phillips S.C., Grimm C.

2010 - Renaissance of ion channel research and drug discovery by patch clamp automation

icon pap  Port-a-Patch,   icon pl   Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE)  publication in Future Medical Chemistry (2010)

Authors:
Farre C. and Fertig N.

2010 - Propranolol blocks cardiac and neuronal voltage-gated sodium channels

icon pl  Patchliner publication in Frontiers in Pharmacology (2010)

Authors: 
Wang D.W., Mistry A.M., Kahlig K.M., Kearney J.A, Xiang J., George Jr. A.L.

2010 - Pregnenolone Sulphate- and Cholesterol-Regulated TRPM3 Channels Coupled to Vascular Smooth Muscle Secretion and Contraction

icon pl  Patchliner publication in Circulation Research (2010)

Authors: 
Naylor J., Li J., Milligan C.J, Zeng F., Sukumar P., Hou B., Sedo A., Yuldasheva N., Majeed Y., Beri D., Jiang S., Seymour V.A.L, McKeown L., Kumar B., Harteneck C., O'Regan D., Wheatcroft S.B., Kearney M.T, Jones C., Porter K.E., Beech D.J.

2010 - Multiplexed transposon-mediated stable gene transfer in human cells

icon pl  Patchliner publication in Proc. Natl. Acad. Sci. USA. (2010)

Authors: 
Kahlig K.M., Saridey S.K., Kaja A., Daniels M.A., George A.L. Jr., Wilson M.H.

2010 - Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae

icon pl  Patchliner publication in Bioorganic & Medical Chemistry (2010)

Authors: 
Balansa W, Islam R, Fontaine F, Piggott AM, Zhang H, Webb TI, Gilbert DF, Lynch JW, Capon RJ.

2010 - Cor.At Cardiomyocytes: Primary-like Cardiomyocytes for Manual and Automated Electrophysiological Screening

icon pap  Port-a-Patch and   icon pl   Patchliner publication in Lonza Resource Notes (2010)

Authors:
Kettenhofen R., Stölzle S.

2009 - Robotic multiwell planar patch-clamp for native and primary mammalian cells

icon pl  Patchliner publication in Nature Protocols (2009)

Authors:
Milligan C.J., Li J., Sukumar P., Majeed Y., Dallas M.L., English A., Emery P., Porter K.E., Smith A.M., McFadzean I., Beccano-Kelly D., Bahnasi Y., Cheong A., Naylor J., Zeng F., Liu X., Gamper N., Jiang L., Pearson H.A., Peers C., Robertson B., Beech D.J.

2009 - Port-a-Patch and Patchliner: High fidelity electrophysiology for secondary screening and safety pharmacology

icon pap  Port-a-Patch and   icon pl   Patchliner publication in Combinatorial Chemistry & High Throughput Screening (2009)

Authors: 
Farre C., Haythornthwaite A., Haarmann C., Stoelzle S., Kreir M., George M., Brüggemann A., Fertig N.

2009 - High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1

icon pl  Patchliner publication in Molecular Pharmacology (2009)

Authors: 
Lewis L.M., Bhave G., Chauder B.A., Banerjee S., Lornsen K.A., Redha R., Fallen K., Lindsley C.W., Weaver C.D., Denton J.S.

2009 - High throughput techniques for discovering new glycine receptor modulators and their binding sites

icon pl  Patchliner publication in Frontiers in Molecular Neuroscience (2009)

Authors: 
Gilbert D.F.,Islam R., Lynagh T., Lynch J.W., Webb T.I. Front.

2008 - TRPC channel activation by extracellular thioredoxin

icon pl  Patchliner publication in Nature (2008)

Authors: 
Xu S.Z., Sukumar P., Zeng F., Li J., Jairaman A., English A., Naylor J., Ciurtin C., Majeed Y., Milligan C.J., Bahnasi Y.M., Al-Shawaf E., Porter K.E., Jiang L.H., Emery P., Sivaprasadarao A., Beech D.J.

2008 - Production of a specific extracellular inhibitor of TRPM3 channels

icon pl  Patchliner publication in British Journal of Pharmacology (2008)

Authors: 
Naylor J., Milligan C.J., Zeng F., Jones C., Beech D.J.

2008 - Ion channel screening – automated patch clamp on the rise

icon pap  Port-a-Patch and   icon pl   Patchliner publication in Drug Discovery Today (2008)

Authors: 
Farre C., George M., Brüggemann A., Fertig N.

2008 - Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells

icon pl  Patchliner publication in Circulation Research (2008)

Authors: 
Li J., Sukumar P., Milligan C.J., Kumar B., Ma Z.Y., Munsch C.M., Jiang L.H., Porter K.E., Beech D.J.

2007 - Planar Patch Clamping

icon pap  Port-a-Patch and   icon pl   Patchliner book chapter in "Patch Clamp Analysis – Advanced Techniques", Series: Neuromethods (2007)

Authors: 
Behrends, J.C., Fertig, N.

2007 - Automated ion channel screening: patch clamping made easy

icon pap  Port-a-Patch and   icon pl   Patchliner publication in Expert Opinion Therapeutic Targets (2007)

Authors: 
Farre C., Stoelzle S., Haarman C., George M., Brueggemann A., Fertig N.

2006 - Microchip technology for automated and parallel patch clamp recording

icon pap  Port-a-Patch and   icon pl   Patchliner publication in Small Journal (2006)

Authors: 
Brüggemann A., Stoelzle S., George M., Behrends J.C., Fertig N.

2020 - Wireless Charging Electrochemiluminescence System for Ionic Channel Manipulation in Living Cells

icon pap   Port-a-Patch publication in ACS Applied Materials & Interfaces (2020)

Authors:
Peng K., Liu S., Lv F., Fu X., Hussain S., Zhao H., Liu L., Wang S.

2020 - Trp, a conserved aromatic residue crucial to the interaction of a scorpion peptide with sodium channels

icon pap   Port-a-Patch Publication found in The Journal of Biochemistry (2020)

Authors:
Xu Y., Sun J., Yu Y., Kong X., Meng X., Liu Y., Cui Y., Su Y., Zhao M., Zhang J. 

2020 - The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics

icon pap Port-a-Patch and  icon vpp Vesicle Prep Pro publication in Scientific Reports (2020)

Authors:
Sancho-Vaello E., Gil-Carton D., François P., Bonetti E.J., Kreir M., Pothula K.R., Kleinekathöfer U., Zeth K.

2020 - Purification and initial characterization of Plasmodium falciparum K+ channels, PfKch1 and PfKch2 produced in Saccharomyces cerevisiae

icon vpp Vesicle Prep Pro and icon pap Port-a-Patch publication in Microbial Cell Factories (2020)

Authors:
Molbaek K., Tejada M., Ricke C.H., Scharff-Poulsen P., Ellekvist P., Helix-Nielsen C., Kumar N., Klaerke D.A., Pedersen P.A.

2020 - New natural agonists of the transient receptor potential Ankyrin 1 (TRPA1) channel

icon pap   Port-a-Patch publication in Nature Scientific Reports (2020)

Authors:
Legrand C., Merlini J.M., de Senarclens‑Bezençon C., Michlig S.

2020 - Mechanism of non-blocking inhibition of sodium channels revealed by conformation-selective photolabeling

icon pap   Port-a-Patch pre-publication in BioRxiv (2020)

Authors:
Földi M.C., Pesti K., Zboray K., Hegedűs T., Málnási-Csizmadia A., Lukács P., Mike A.

2020 - Ionophore constructed from non-covalent assembly of a G-quadruplex and liponucleoside transports K+-ion across biological membranes

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Nature Communications (2020)

Authors: 
Debnath M., Chakraborty S., Kumar Y.P., Chaudhuri R., Jana B., Dash J.

2020 - Interferon-γ and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage

icon pap   Port-a-Patch publication in Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (2020)

Authors: 
Sáez J.C., Contreras-Duarte S., Labra V.C., Santibañez C.A., Mellado L.A., Inostroza C.A., Alvear T.F., Retamal M.A., Velarde V., Orellana J.A..

2020 - Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Cell Calcium (2020)

Authors: 
Moparthi L., Zygmunt P.M.

2020 - Homocysteine-induced electrical remodeling via the mediation of IP 3 R1/Nav1.5 signaling pathway

icon pap  Port-a-Patch publication in American Journal of Translational Research (2020)

Authors:
Han L., Wu A., Li Q., Xia Z., Wu Y., Hong K., Xia Z., Li J.

2020 - Hepatitis C Virus p7 Induces Membrane Permeabilization by Interacting with Phosphatidylserine

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in International Journal of Molecular Sciences (2020)

Authors: 
Lee H-R., Lee G.Y., You D-G., Kim H.K., Yoo Y.D.

2020 - Fenamates Inhibit Human Sodium Channel Nav1.2 and Protect Glutamate-Induced Injury in SH-SY5Y Cells

icon pap   Port-a-Patch publication in Cellular and Molecular Neurobiology (2020)

Authors:
Sun J.F., Zhao M.Y., Xu Y.J., Su Y., Kong X.H., Wang Z.Y.

2020 - Electrophysiological Characterization of Transport Across Outer-Membrane Channels From Gram-Negative Bacteria in Presence of Lipopolysaccharides

icon pap   Port-a-Patch publication in Frontiers in Angewandte Chemie International Edition Engl. (2020)

Authors:
Wang J., Terrasse R., Bafna J.A., Benier L., Winterhalter M.

2020 - Electrophysiological characterization of transport across outer membrane channels from Gram‐negative bacteria in presence of lipopolysaccharides (LPS)

icon pap   Port-a-Patch,  icon vpp   Vesicle Prep Pro and   Icon Orbit Mini   Orbit mini Publication in Angewandte Chemie International Edition (2020)

Authors:
Wang J., Terrasse R., Bafna J.A., Benier L., Winterhalter M.

2020 - Conformational equilibrium shift underlies altered K+ channel gating as revealed by NMR

icon pap Port-a-Patch and  icon vpp Vesicle Prep Pro publication in Nature Communications (2020)

Authors:
Iwahasi Y., Toyama Y., Imai S., Itoh H., Osawa M., Inoue M., Shimada I.

2020 - Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38δ MAPK-dependent exocytosis in pancreatic β-cells

icon pap   Port-a-Patch publication in Clinical Science (2020)

Authors:
Chen J., Wang F., Zhou Y., Jiang J., Ksimu S., Zhang X., Li J.Z., Niu J., Wang Q.

2020 - Calcium activates purified human TRPA1 with and without its N-terminal ankyrin repeat domain in the absence of calmodulin

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Cell Calcium (2020)

Authors: 
Moparthi L., Moparthi S.B., Wenger J., Zygmunt P.M.

2020 - Automated Patch Clamp in Drug Discovery: major breakthroughs and innovation in the last decade

 icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i instrument)   icon pl   Patchliner and   icon pap   Port-a-Patch publication in Expert Opinion on Drug Discovery (2020)

Authors:
Obergrussberger A., Friis S., Brüggemann A., Fertig N.

2020 - Ascorbate-induced oxidative stress mediates TRP channel activation and cytotoxicity in human etoposide-sensitive and -resistant retinoblastoma cells

icon pap Port a Patch publication in Laboratory Investigation (2020)

Authors:
Oronowicz J., Reinhard J., Reinach P.S., Ludwiczak S., Luo H., Salem M.H.O.B., Kraemer M.M., Biebermann H., Kakkassery V., Mergler S.

2020 - Arterial Medial Calcification through Enhanced small Extracellular Vesicle Release in Smooth Muscle-Specific Asah1 Gene Knockout Mice

icon pap  Port-a-Patch publication in Nature Scientific Reports (2020)

Authors:
Bhat O.M., Li G., Yuan X., Huang D., Gulbins E., Kukreja R.C., Li P-L.

2020 - Addressing hERG activity while maintaining favorable potency, selectivity and pharmacokinetic properties of PPARδ modulators

icon pap   Port-a Patch Publication in Bioorganic & Medicinal Chemistry Letters (2020)

Authors:
Lagu B., Senaiar R.S., Kluge A.F., Mallesh B., Ramakrishna M., Bhat R., Patane M.A.

2019 - Temporin L and aurein 2.5 have identical conformations but subtly distinct membrane and antibacterial activities

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Nature Scientific Reports (2019)

Authors:
Manzo G., Ferguson P.M., Hind C.H., Clifford M., Gustilo V.B., Ali H., Bansal S.S., Bui T.T., Drake A.F., Atkinson R.A., Sutton J.M., Lorenz C.D., Phoenix D.A., Mason A.J.

2019 - Structure of the human ClC-1 chloride channel

icon pap   Port-a-Patch,  icon vpp   Vesicle Prep Pro and   Icon Orbit Mini   Orbit mini publication in PLOS Biology (2019)

Authors:
Wang K., Preisler, SS, Zhang, L., Cui, Y., Missel, JW., Grønberg C., Gotfryd, K., Lindahl E., Andersson, M., Calloe, K., Egea P.F., Klaerke D.A., Pusch M., Pedersen P.A., Zhou, Z.H., Gourdon, P.

2019 - Screening by changes in stereotypical behavior during cell motility

icon pap   Port-a Patch Publication in Scientific Reports (2019)

Authors:
Tweedy L., Witzel P., Heinrich D., Insall R.H., Endres R.G.

2019 - Role of High‐Throughput Electrophysiology in Drug Discovery

icon sp96   SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i),   icon pl   Patchliner and   icon pap   Port-a-Patch review article in Current Protocols in Pharmacology (2019)

Authors:
Liu C., Li T., Chen J.

2019 - Postpartum hormones oxytocin and prolactin cause pro-arrhythmic prolongation of cardiac repolarization in long QT syndrome type 2

icon pap   Port-a Patch Publication in EP Europace (2019)

Authors:
Bodi I., Sorge J., Castiglione A., Glatz S.M., Wuelfers E.M., Franke G., Perez-Feliz S., Koren G., Zehender M., Bugger H., Seemann G., Brunner M., Bode C., Odening K.E.

2019 - NPPB prevents postoperative peritoneal adhesion formation by blocking volume-activated Cl− current

icon pap   Port-a Patch Publication in Naunyn-Schmiedeberg's Archives of Pharmacology (2019)

Authors:
Zhong, J., Qin Z., Yu H., Liu X., Li C., Shi J., Mao J., Xu B.

2019 - NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells-A Potential Target for Adjuvant Radiotherapy

icon pap   Port-a Patch Publication in Cancers (2019)

Authors:
Müller-Längle A., Lutz H., Hehlgans S., Rödel F., Rau K., Laube B.

2019 - Molecular understanding of calcium permeation through the open Orai channel

icon pap   Port-a Patch and   icon vpp    Vesicle Prep Pro Publication in PLOS Computational Biology (2019)

Authors:
Liu X., Wu G., Yu Y., Chen X., Ji R., Lu J., Li X., Zhang X., Yang X., Shen Y.

2019 - Modulation of the potassium channel KcsA by anionic phospholipids: Role of arginines at the non-annular lipid binding sites

icon pap   Port-a Patch Publication in BBA - Biomembranes (2019)

Authors:
Poveda J.A., Giudici A.M., Renart M.L., Millet O., Morales A., González-Ros J.M., Oakes V., Furini S., Domene C

2019 - Mitragynine, an euphoric compound inhibits hERG1a/1b channel current and upregulates the complexation of hERG1a-Hsp90 in HEK293-hERG1a/1b cells

icon pap   Port-a Patch Publication in Nature Scientific Reports (2019)

Authors:
Tay Y.L., Amanah A., Adenan M.I., Wahab H.A., Tan M.L.

2019 - Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Nature Scientific Reports (2019)

Authors:
Manzo G., Ferguson P.M., Gustilo V.B., Ali H., Bui T.T., Drake A.F., Atkinson R.A., Batoni G., Lorenz C.D., Phoenix D.A., Mason A.J.

2019 - KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis

icon pap   Port-a-Patch publication in Arthritis Research & Therapy (2019)

Authors:
Tanner M.R., Pennington M.W., Chauhan S.S., Laragione T., Gulko P.S., Beeton C.

2019 - Inhibition of Polyamine Biosynthesis Reverses Ca2+ Channel Remodeling in Colon Cancer Cells

icon pap   Port-a-Patch publication in Cancers (2019)

Authors:
Gutiérrez L.G., Hernández-Morales M., Núñez L., Villalobos C.

2019 - High-resolution experimental and computational electrophysiology reveals weak β-lactam binding events in the porin PorB

icon pap   Port-a-Patch publication in Nature Scientific Reports (2019)

Authors:
Bartsch A., Llabrés S., Pein F., Kattner C., Schön M., Diehn M., Tanabe M., Munk A., Zachariae U., Steinem C.

2019 - Golgi anti-apoptotic proteins are evolutionarily conserved ion channels that regulate cell death in plants

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro Pre-publication in BioRxiv (2019)

Authors:
Sierla M., Prole D.L., Saraiva N., Carrara G., Dinischiotu N., Vaattovaara A., Wrzaczek M., Taylor C.W., Smith F.L., Feys B.

2019 - Fenamates inhibit human sodium channel Nav1.7 and Nav1.8

icon pap   Port-a-Patch publication in Neuroscience Letters (2019)

Authors:
Sun, J-F., Xu, Y-J., Kong, X-H., Su, Y., Wang, Z-Y.

2019 - Control of Lysosomal TRPML1 Channel Activity and Exosome Release by Acid Ceramidase in Mouse Podocytes

icon pap   Port-a Patch Publication in American Journal of Physiology Cell Physiology (2019)

Authors:
Li G., Huang D., Hong J., Bhat O.M., Yuan X., Li P.L.

2019 - Breaching the Barrier: Quantifying Antibiotic Permeability across Gram-Negative Bacterial Membranes

icon pap   Port-a Patch Publication in Journal of Molecular Biology (2019)

Authors:
Cama J., MaeHenney A., Winterhalter M.

2019 - Action of MK‐7264 (Gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation

icon pap   Port-a-Patch publication in British Journal of Pharmacology (2019)

Authors:
Richards D., Gever J.R., Ford A.P., Fountain S.J.

2019 - Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures

icon pap   Port-a Patch and Internal Perfusion Publication in JCI Insight (2019)

Authors:
Hammelmann, V., Stieglitz, M.S., Hülle, H., Le Meur, K., Kass, J., Brümmer, M., Gruner, C., Rötzer, R.D., Fenske, S., Hartmann, J., Zott, B., Lüthi, A., Spahn, S., Moser, M,, Isbrandt, D., Ludwig, A., Konnerth, A., Wahl-Schott, C., Biel M.

2018 - Vascular Endothelial Growth Factor (VEGF) Induced Downstream Responses to Transient Receptor Potential Vanilloid 1 (TRPV1) and 3-Iodothyronamine (3-T1AM) in Human Corneal Keratocytes

icon pap   Port-a-Patch publication in Frontiers in Pharmacology (2018)

Authors:
Türker, E., Garreis, F., Khajavi, N., Reinach, P.S., Joshi, P., Brockmann, T., Lucius, A., Ljubojevic, N., Turan, E., Cooper, D., Schick, F., Reinholz, R., Pleyer, U., Köhrle, J., Mergler, S.

2018 - TRPM8 Activation via 3-Iodothyronamine Blunts VEGF-Induced Transactivation of TRPV1 in Human Uveal Melanoma Cells

icon pap   Port-a-Patch publication in Frontiers in Pharmacology (2018)

Authors:
Walcher, L., Budde, C., Böhm, A., Reinach, P.S., Dhandapani, P., Ljubojevic, N., Schweiger, M.W., von der Waydbrink, H., Reimers, I., Köhrle, J., Mergler, S.

2018 - Thymol Induces Conidial Apoptosis in Aspergillus flavus via Stimulating K+ Eruption

icon pap   Port-a-Patch publication in Journal of Agricultural and Food Chemistry (2018)

Authors:
Hu L.-B., Ban F.-F., Li H.-B., Qian P.-P., Shen Q.-S., Yan-Zhao Y., Mo H.-Z., Zhou X.

2018 - Temperature-Induced Modulation of Voltage-Gated Ion Channels in Human Lung Cancer Cell Line A549 Using Automated Patch Clamp Technology

icon pap   Port-a-Patch book chapter in World Congress on Medical Physics and Biomedical Engineering 2018.

Authors:
Langthaler S., Bergmoser K., Lassnig A., Baumgartner C.

2018 - Targeting KCa1.1 channels with a scorpion venom peptide for the therapy of rat models of rheumatoid arthritis

icon pap   Port-a-Patch publication in The Journal of Pharmacology and Experimental Therapeutics (2018)

Authors:
Tanner M.R., Pennington R.W., Chamberlain B.H., Huq R., Gehrmann E.J., Laragione, T., Gulko P.S., Beeton C.

2018 - Structure of the mechanosensitive OSCA channels

icon pap   Port-a-Patch Suction Control Pro publication in Nature Structural & Molecular Biology (2018)

Authors:
Zhang M., Wang D., Kang Y., Wu J.-X., Yao F., Pan C., Yan Z., Song C., Chen L.

2018 - Single channel recording of a mitochondrial calcium uniporter

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in BBRC (2018)

Authors: 
Wu G., Li S., Zong G., Liu, X., Fei S., Shen L., Guan X., Yanga X., Shen Y.

2018 - Romo1 is a mitochondrial nonselective cation channel with viroporin-like characteristics

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Journal of Cell Biology (2018)

Authors:
Lee G.Y., You D.G., Lee H.R., Hwang S.W., Lee C.J., Do Yoo Y.

2018 - Role of the Fourth Transmembrane Segment in TRAAK Channel Mechanosensitivity

icon pap   Port-a-Patch Suction Control Pro pre-publication in bioRxiv (2018)

Authors:
Zhang M., Yao F., Pan C., Yan Z.

2018 - Reconstitution and Electrophysiological Characterization of Ion Channels in Lipid Bilayers

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Current Protocols in Pharmacology (2018)

Authors:
Klaerke D.A., de los Angeles Tejada M., Grøsfjeld Christensen V., Lassen M., Amstrup Pedersen P., Calloe K.

2018 - Quantifying Permeation of Small Charged Molecules across Channels: Electrophysiology in Small Volumes

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in ACS Omega (2018)

Authors:
Wang J., Benier L., Winterhalter M.

2018 - Powering the ABC multidrug exporter LmrA: How nucleotides embrace the ion-motive force

icon pap   Port-a-Patch publication in Science Advances (2018)

Authors:
Agboh K., Lau C.H.F., Khoo Y.S.K., Singh H., Raturi S., Nair A.V., Howard J., Chiapello M., Feret R., Deery M.J., Murakami S., van Veen H.W.

2018 - Parallel evolution of frog antimicrobial peptides produces identical conformations but subtly distinct membrane and antibacterial activities

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro pre-publication in bioRxiv (2018)

Authors:
Manzo G., Ferguson P.M., Hind C., Clifford M., Gustilo V.B., Ali H., Bansal S.S., Bui T.T., Drake A.F., Atkinson R.A., Sutton M.J., Lorenz C.D., Phoenix D.A., Mason A.J.

2018 - Non-blocking modulation contributes to sodium channel inhibition by a covalently attached photoreactive riluzole analog

icon pap   Port-a-Patch publication in Nature Scientific Reports (2018)

Authors:
Lukacs P., Mátyás F.C., Valánszki L., Casanova E., Biri-Kovács B., Nyitray L., Málnási-Csizmadia A., Mike A.

2018 - Molecular mechanism of the Orai channel activation

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro Pre-publicatin in bioRxiv (2018)

Authors:
Liu, X., Wu, G., Yu, Y., Chen, X., Ji, R., Lu, J., Li, X., Zhang, X., Yang, X., Shen, Y.

2018 - Interaction of Gravity with Cellular Compounds

icon pap   Port-a-Patch book chapter in Gravitational Biology II (2018)

Authors:
Hanke W., Kohn F.P.M., Neef M. Hampp R. 

2018 - Inhibition of pannexin-1 channel activity by adiponectin in podocytes: Role of acid ceramidase activation

icon pap   Port-a-Patch publication in BBA - Molecular and Cell Biology of Lipids (2018)

Authors:
Li G., Zhang Q., Hong J., Ritter J.K., Li P.-L.

2018 - Functional Analysis of Membrane Proteins Produced by Cell-Free Translation

icon pap   Port-a-Patch and   Icon Orbit Mini   Orbit mini article in Protein Engineering (2018)

Authors:
Dondapati S.K., Wüstenhagen D.A., Kubick S.

2018 - Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation

icon pap   Port-a-Patch publication in Circulation (2018)

Authors:
Yao C., Veleva T., Scott L., Cao S., Li L., Chen G., Jeyabal P., Pan X., Alsina K.M., Abu-Taha I., Ghezelbash S., Reynolds C.L., Shen Y.H., LeMaire S.A., Schmitz W., Müller F.U., El-Armouche A., Eissa N.T., Beeton C., Nattel S. , Wehrens X.H.T., Dobrev D., Li N.

2018 - Electrophysiological experiments in microgravity: lessons learned and future challenges

icon pap   Port-a-Patch publication in Microgravity (2018)

Authors:
Wuest S.L., Gantenbein B., Ille F.,Egli M.

2018 - An aromatic cluster in Lysinibacillus sphaericus BinB involved in toxicity and proper in-membrane folding

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Archives of Biochemistry and Biophysics (2018)

Authors:
Chooduang A., Surya W., Torres J., Boonserm P.

2018 - An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1

icon pap   Port-a-Patch publication in Journal of General Physiology (2018)

Authors:
Vaisey G., Long S.B.

2018 - 3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines

icon pap   Port-a-Patch publication in Frontiers in Endocrinology (2018)

Authors:
Bräunig J., Mergler S., Jyrch S., Hoefig C.S., Rosowski M., Mittag J., Biebermann H., Khajavi N.

2017 - The Rotavirus NSP4 Viroporin Domain is a Calcium-conducting Ion Channel

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Nature Scientific Reports

Authors:
Pham T., Perry J.L., Dosey T.L., Delcour L.H.,Hyser J.M.

2017 - Synthetic Channel Specifically Inserts into the Lipid Bilayer of Gram-Positive Bacteria but not that of Mammalian Erythrocytes

icon pap    Port-a-Patch publication in Angewandte Chemie (2017)

Authors:
Zhang M., Zhu P.P., Xin P., Si W., Li Z.T., Hou J.L.

2017 - Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog

icon pap   Port-a-Patch publication in Clinical Immunology (2017)

Authors:
Tanner M.R., Tajhya R.B., Huq R., Gehrmann E.J., Rodarte K.E., Atik M.A., Norton R.S., Pennington R.W., Beeton C.

2017 - Polydim-I antimicrobial activity against MDR bacteria and its model membrane interaction

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in PLoS ONE (2017)

Authors: 
Rangel M., Fernandes dos Santos Castro F., Mota-Lima L.D., Clissa P.B., Martins D.B., Perez dos Santos Cabrera M., Mortari M.R.

2017 - Peptidomic analysis of the venom of the solitary bee Xylocopa appendiculata circumvolans

icon pap   Port-a-Patch publication in Journal of Venomous Animals and Toxins including Tropical Diseases (2017)

Authors:
Kazuma K., Ando K., Nihei K., Wang X., Rangel M., Franzolin M.R., Mori-Yasumoto K., Sekita S., Kadowaki M., Satake M., Konno K.

2017 - Organelle membrane derived patches: reshaping classical methods for new targets

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Nature Scientific Reports (2017)

Authors:
Shapovalov G., Ritaine A., Bidaux G., Slomianny, C., Borowiec A-S., Gordienko D., Bultynck G., Skryma R., Prevarskaya N.

2017 - Mitochondria sustain store-operated currents in colon cancer cells but not in normal colonic cells: reversal by non-steroidal anti-inflammatory drugs

icon pap   Port-a-Patch publication in Oncotarget (2017)

Authors:
Hernández-Morales M., Sobradillo D., Valero R.A., Muñoz E., Ubierna D., Moyer M.P., Núñez L., Villalobos C.

2017 - Evaluation of the antimicrobial activity of the mastoparan Polybia-MPII isolated from venom of the social wasp Pseudopolybia vespiceps testacea (Vespidae, Hymenoptera)

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in International Journal of Antimicrobial Agents (2017)

Authors: 
Silva J.C., Neto L.M., Neves R.C., Gonçalves J.C., Trentini M.M., Mucury-Filho R., Smidt K.S., Fensterseifer I.C., Silva O.N., Lima L.D., Clissa P.B., Vilela N., Guilhelmelli F., Silva L.P., Rangel M., Kipnis A., Silva-Pereira I., Franco O.L., Junqueira-Kipnis A.P., Bocca A.L., Mortari M.R.

2017 - Cytotoxic effect of zinc oxide nanoparticles on murine photoreceptor cells via potassium channel block and Na+/K+‐ATPase inhibition

icon pap   Port-a-Patch publication in Cell Proliferation (2017)

Authors:
Chen C. Bu W., Ding H., Li Q., Wang D., Bi H., Guo D.

2017 - Buserelin alleviates chloride transport defect in human cystic fibrosis nasal epithelial cells

icon pap  Port-a-Patch publication in PLoS ONE (2017)

Authors: 
Calvez M.L., Benz N., Huguet F., Saint-Pierre A., Rouillé E., Coraux C., Férec C., Kerbiriou M., Trouvé P.

2017 - Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Structure (2017)

Authors: 
Arya P, Jarerattanachat V., Clausen M.V., Schewe M., McClenaghan C., Argent L., Conrad L.J., Dong Y.Y., Pike A.C.W., Carpenter E.P., Baukrowitz T., Sansom M.S.P., Tucker S.J.

2017 - Asymmetric mechanosensitivity in a eukaryotic ion channel

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in PNAS (2017)

Authors:
Clausen M.V., Jarerattanachata V., Carpenterc E.P., Mark S. , Sansomb P., Tucker S.J.

2017 - A mutant of the Buthus martensii Karsch antitumor-analgesic peptide exhibits reduced inhibition to hNav1.4 and hNav1.5 channels while retaining analgesic activity

icon pap   Port-a-Patch publication in Journal of Biological Chemistry (2017)

Authors:
Xu Y., Meng X., Hou X., Sun J., Kong X., Sun Y., Liu Z., Ma Y., Niu Y., Song Y., Cui Y., Zhao M., Zhang J.

2016 - Voltage Dependence of Conformational Dynamics and Subconducting States of VDAC-1

icon pap  Port-a-Patch publication in Biophysical Journal (2016)

Authors: 
Briones R., Weichbrodt C., Paltrinieri L., Mey I., Villinger S., Giller K., Lange A., Zweckstetter M., Griesinger C., Becker S., Steinem C., de Groot B.L.

2016 - Upregulation of Transient Receptor Potential Vanilloid Type-1 Channel Activity and Ca2+ Influx Dysfunction in Human Pterygial Cells

icon pap  Port-a-Patch publication in Investigative Opthalmology & Visual Science (2016)

Authors: 
Garreis F., Schröder A., Reinach P.S., Zoll S., Khajavi N., Dhandapani P., Lucius A., Pleyer U., Paulsen F., Mergler S.

2016 - The N-terminal Ankyrin Repeat Domain Is Not Required for Electrophile and Heat Activation of the Purified Mosquito TRPA1 Receptor

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Nature (2016)

Authors: 
Survery S., Moparthi L., Kjellbom P., Högestätt E.D., Zygmunt P.M., Johanson U.

2016 - Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Nature Communications (2016)

Authors:
Dhakshnamoorthy B., Rohaim A., Rui H., Blachowicz L., Roux B.

2016 - Reversible control of current across lipid membranes by local heating

icon pap  Port-a-Patch publication in Scientific Reports (2016)

Authors: 
Urban P., Kirchner S.R., Mühlbauer C., Lohmüller T., Feldmann J.

2016 - Pore architecture of TRIC channels and insights into their gating mechanism

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Nature (2016)

Authors: 
Yang H., Hu M., Guo J., Ou X., Cai T., Liu Z.

2016 - Photosensitization in Porphyrias and Photodynamic Therapy Involves TRPA1 and TRPV1

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in The Journal of Neuroscience (2016)

Authors: 
Babes A., Sauer S.K., Moparthi L., Kichko T.I., Neacsu C., Namer B., Filipovic M., Zygmunt P.M., Reeh P.W., Fischer M.J.

2016 - Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Scientific Reports (2016)

Authors: 
Moparthi L., Kichko T. I., Eberhardt M., Högestätt E. D., Kjellbom P., Johanson U., Reeh P., W., Leffler A., Filipovic M. R., Zygmunt P. M.

2016 - Functional characterization of p7 viroporin from hepatitis C virus produced in a cell-free expression system

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Protein Expression and Purification (2016)

Authors: 
Soranzo T., Cortès S., Gilde F., Kreir M., Picart C., Lenormand J.-L.

2016 - Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel

icon pap  Port-a-Patch publication in Proceedings of the National Academy of Sciences of the United States of America (2016)

Authors: 
Vaisey G., Miller A.N., Long S.B.

2016 - Defined Medium Conditions for the Induction and Expansion of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium

icon pap  Port-a-Patch publication in Stem Cell Reviews and Reports (2016)

Authors: 
Lidgerwood G.E., Lim S.Y., Crombie D.E., Ali R., Gill K.P., Hernández D., Kie J., Conquest A., Waugh H.S., Wong R.C., Liang H.H., Hewitt A.W., Davidson K.C., Pébay A.

2016 - Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation

icon pl  Patchliner publication in Journal of the American College of Cardiology (2016)

Authors:
Lorberbaum T., Sampson K.J., Chang J.B., Iyer V., Woosley R.L., Kass R.S., Tatonetti N.P.

2016 - Conductance and Capacity of Plain Lipid Membranes under Conditions of Variable Gravity

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Journal of Biomedical Science and Engineering (2016)

Authors: 
Sieber M., Kaltenbach S., Hanke W. and Kohn F.P.M

2015 - The Functional Property Changes of Muscular Nav1.4 and Cardiac Nav1.5 Induced by Scorpion Toxin BmK AGP-SYPU1 Mutants Y42F and Y5F

icon pap  Port-a-Patch publication in Biochemistry (2015)

Authors: 
Meng x., Xu Y., Zhao M., Wang F., Ma Y., Jin Y., Liu Y., Song Y., Zhang J.

2015 - Quantification of Fluoroquinolone Uptake through the Outer Membrane Channel OmpF of Escherichia coli

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Journal of the American Chemical Society (2015)

Authors: 
Cama J., Bajaj H., Pagliara S., Maier T., Braun Y., Winterhalter M., Keyser U.F.

2015 - K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

icon pap  Port-a-Patch publication in Science (2015)

Authors: 
Dong Y.Y., Pike A.C., Mackenzie A., McClenaghan C., Aryal P., Dong L., Quigley A., Grieben M., Goubin S., Mukhopadhyay S., Ruda G.F., Clausen M.V., Cao L., Brennan P.E., Burgess-Brown N.A., Sansom M.S., Tucker S.J., Carpenter E.P.

2015 - Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Journal of Biological Chemistry (2015)

Authors: 
Carrara G., Saraiva N., Parsons M., Byrne B., Prole D.L., Taylor C.W., Smith G.L.

2015 - Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes As Revealed by Intrinsic Tryptophan Fluorescence Quenching

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Journal of Biological Chemistry (2015)

Authors: 
Billen B., Brams M., Debaveye S., Remeeva A., Alpizar Y.A., Waelkens E., Kreir M., Brüggemann A., Talavera K., Nilius B., Voets T., Ulens C.

2015 - Cell-free expression of a functional pore-only sodium channel

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Protein Expression and Purification (2015)

Authors:
Kovácsová G, Gustavsson E, Wang J, Kreir M, Peuker S, Westenhoff S.

2015 - Antibiotic translocation through porins studied in planar lipid bilayers using parallel platforms

Icon Orbit  Orbit 16,   icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Analyst (2015)

Authors:
Weichbrodt C., Bajaj H., Baaken G., Wang J., Guinot S., Kreir M, Behrends J.C., Winterhalter M., Fertig N.

2014 - Ultra-stable glass microcraters for on-chip patch clamping

icon pap  Port-a-Patch publication in Joyal Society of Chemistry Advances (2014)

Authors: 
Stava E., Shin H.C.,Yu M., Bhat A., Resto P.J., Seshadri A., Williams J.C., Blick R.H.

2014 - Temperature-sensitive gating of hCx26: high-resolution Raman spectroscopy sheds light on conformational changes

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Biomedical Optics Express (2014)

Authors:
Kniggendorf A.-K., Meinhardt-Wollweber M., Yuan X., Roth B., Seifert A., Fertig N., Zeilinger C.

2014 - Studying mechanosensitive ion channels with an automated patch clamp

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in European Biophysics Journal (2014)

Authors:
Barthmes M.,  Mac Donald F.J., Birkner J.P., Brüggemann A., Wahl-Schott C., Koçer A.

2014 - Structure of a Conserved Golgi Complex-targeting Signal in Coronavirus Envelope Proteins

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Journal of Biological Chemistry (2014)

Authors: 
Li Y., Surya W., Claudine S., Torres J.

2014 - Membrane assembly of the functional KcsA potassium channel in a vesicle-based eukaryotic cell-free translation system

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Biosensors and Bioelectronics (2014)

Authors: 
Dondapati S.K., Kreir M., Quast R.B., Wüstenhagen D.A., Brüggemann A., Fertig N., Kubick S.

2014 - L-Carnitine Reduces in Human Conjunctival Epithelial Cells Hypertonic- Induced Shrinkage through Interacting with TRPV1 Channels

icon pap  Port-a-Patch publication in Cellular Physiology and Biochemistry (2014)

Authors:
Khajavi N., Reinach P.S., Skrzypski M., LudeA., Mergler S.

2014 - KCNMA1 Encoded Cardiac BK Channels Afford Protection against Ischemia-Reperfusion Injury

icon pap  Port-a-Patch publication in PLoS One (2014)

Authors: 
Soltysinska E., Bentzen B.H., Barthmes M., Hattel H., Thrush A.B., Harper M.E., Qvortrup K., Larsen F.J., Schiffer T.A., Losa-Reyna J., Straubinger J., Kniess A., Thomsen M.B., Brüggemann A., Fenske S., Biel M., Ruth P., Wahl-Schott C., Boushel R.C., Olesen S.P., Lukowski R.

2014 - Improvement of Chloride Transport Defect by Gonadotropin-Releasing Hormone (GnRH) in Cystic Fibrosis Epithelial Cells

icon pap  Port-a-Patch publication in PLoS One (2014)

Authors: 
Benz N., Le Hir S., Norez C., Kerbiriou M., Calvez M.-L., Becq F., Trouvé P. , Férec C.

2014 - Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Proceedings of the National Academy of Sciences of the United States of America (2014)

Authors: 
Moparthi L., Survery S., Kreir M., Simonsen C., Kjellbom P., Högestätt E.D., Johanson U., Zygmunt P.M.

2014 - High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

icon pap  Port-a-Patch publication in Nature Communications (2014)

Authors: 
Grimm C., Holdt L.M., Chen C.C., Hassan S., Müller C., Jörs S., Cuny H., Kissing S., Schröder B., Butz B., Northoff B., Castonguay J., Luber C.A., Moser M., Spahn S., Lüllmann-Rauch R., Fendel C., Klugbauer N., Griesbeck O., Haas A., Mann M., Bracher F., Teupser D., Saftig P., Biel M., Wahl-Schott C.

2014 - Crystal structure of a human GABAA receptor

icon pap  Port-a-Patch publication in Nature (2014)

Authors:
Miller P.S., Aricescu A.R.

2014 - Calcium regulation by temperature-sensitive transient receptor potential channels in human uveal melanoma cells

icon pap  Port-a-Patch publication in Cellular Signalling (2014)

Authors:
Mergler S., Derckx R., Reinach P.S., Garreis F., Böhm A., Schmelzer L., Skosyrski S., Ramesh N., Abdelmessih S., Polat O.K., Khajavi N., Riechardt A.I.

2014 - Automated Patch Clamp Analysis of nAChα7 and NaV1.7 Channels

icon pap  Port-a-Patch and   icon pl   Patchliner publication in Current Protocols in Pharmacology (2014)

Authors: 
Obergrussberger A., Haarmann C., Rinke I., Becker N., Guinot D., Brueggemann A., Stoelzle-Feix S., George M., Fertig N.

2014 - An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Proceedings of the National Academy of Sciences of the United States of America (2014)

Authors: 
Danilchanka A., Sun J., Pavlenok M., Maueröder C., Speer A., Siroy A., Marrero J., Trujillo C., Mayhew D.L., Doornbos K.S., Muñoz 'L.E., HerrmannM., EhrtS., Berens C., Niederweisa M.

2014 - A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV

icon pap  Port-a-Patch publication in Nature Communications (2014)

Authors:
Chen C.C., Keller M., Hess M., Schiffmann R., Urban N., Wolfgardt A., Schaefer M., Bracher F., Biel M., Wahl-Schott C., Grimm C.

2014 - A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

icon pap  Port-a-Patch publication in Nature Scientific Reports (2014)

Authors: 
Rashid M.H., Huq R., Tanner M.R., Chhabra S., Khoo K.K., Estrada R., Dhawan V., Chauhan S., Pennington M.W., Beeton C., Kuyucak S., Norton R.S.

2013 - Monoacylglycerols Activate TRPV1 – A Link between Phospholipase C and TRPV1

icon pap   Port-a-Patch publication in PLoS One (2013)

Authors: 
Zygmunt P.M., Ermund A., Movahed P., Andersson D.A., Simonsen C., Jönsson B.A., Blomgren A., Birnir B., Bevan S., Eschalier A., Mallet C., Gomis A., Högestätt E.D.

2013 - Functional significance of thermosensitive transient receptor potential melastatin channel 8 (TRPM8) expression in immortalized human corneal endothelial cells

icon pap  Port-a-Patch publication in Experimental Eye Research (2013)

Authors: 
Mergler S., Mertens C., Valtink M., Reinach P.S., Castelo Székely V., Slavi N., Abdelmessih S., Türker E., Fels G., Pleyer U.

2013 - Differential Effects of the β‐Adrenoceptor Blockers Carvedilol and Metoprolol on SQT1‐ and SQT2‐Mutant Channels

icon pap   Port-a-Patch publication in Journal of Cardiovascular Electrophysiology (2013)

Authors: 
Bodi I., Franke G., Pantulu N.D., Wu K., Perez-Feliz S., Bode C., Zehender M., Zur Hausen A., Brunner M., Odening K.

2013 - Crystal structure and functional mechanism of a human antimicrobial membrane channel

icon pap   Port-a-Patch publication in Proceedings of the National Academy of Sciences of the United States of America (2013)

Authors: 
Songa C., Weichbrodt C., Salnikov E.S., Dynowski M.,Forsberg B.O., Bechinger B., Steinem C., de Groot B.L., Zachariae U. and Zeth K.

2013 - A Potent and Selective Peptide Blocker of the Kv1.3 Channel: Prediction from Free-Energy Simulations and Experimental Confirmation

icon pap   Port-a-Patch publication in PLoS ONE (2013)

Authors:
Rashid M.H., Heinzelmann G., Huq R., Tajhya R.B., Chang S.C., Chhabra S., Pennington M.W., Beeton C., Norton R.S., Kuyucak S.

2012 - Thermo-sensitive transient receptor potential vanilloid channel-1 regulates intracellular calcium and triggers chromogranin A secretion in pancreatic neuroendocrine BON-1 tumor cells

icon pap   Port-a-Patch publication in Cellular Signalling (2012)

Authors: 
Mergler S., Skrzypski M., Sassek M., Pietrzak P., Pucci C., Wiedenmann B., Strowski M.Z.

2012 - Selective modification of the N-Terminal structure of polytheonamide B significantly changes its cytotoxicity and activity as an ion channel

icon pap   Port-a-Patch publication in ChemMedChem (2012)

Authors: 
Shinohara N., Itoh H., Matsuoka S., Inoue M.

2012 - Regulation of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Activity by cCMP

icon pap   Port-a-Patch publication in Journal of Biological Chemistry (2012)

Authors: 
Zong X., Krause S., Chen C.C., Krüger J., Gruner C., Cao-Ehlker X., Fenske S., Wahl-Schott C., Biel M.

2012 - Natural and artificial ion channels for biosensing platforms

icon pap   Port-a-Patch,   icon pl   Patchliner,   icon sp96   SyncroPatch 96 ((a predecessor model of SyncroPatch 384PE) and   icon vpp   Vesicle Prep Pro publication in Analytical and Bioanalytical Chemistry (2012)

Authors: 
Steller L., Kreir M., Salzer R.

2012 - Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels

icon pap   Port-a-Patch publication in Biochemical Pharmacology (2012)

Authors: 
Vetter I., Dekan Z., Knapp O., Adams D.J., Alewood P.F., Lewis R.J.

2012 - Interleukin-1R3 mediates interleukin-1–induced potassium current increase through fast activation of Akt kinase

icon pap   Port-a-Patch publication in Proceedings of the National Academy of Sciences of the Unites States of America (2012)

Authors: 
Qian J., Zhu L., Li Q., Belevych N., Chen Q., Zhao F., Herness S., Quan N.

2012 - Insulin-secreting INS-1E cells express functional TRPV1 channels

icon pap   Port-a-Patch publication in Islets (2012)

Authors: 
Fågelskiöld A.J., Kannisto K., Boström A., Hadrovic B., Farre C., Eweida M., Wester K., Islam MD.S.

2012 - HTS techniques for patch clamp-based ion channel screening - economy and advances

icon pap   Port-a-Patch,   icon pl   Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) publication in Expert Opinion on Drug Discovery (2012)

Authors: 
Farre C. and Fertig N.

2012 - Green Fluorescent Protein Changes the Conductance of Connexin 43 (Cx43) Hemichannels Reconstituted in Planar Lipid Bilayer

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in The Journal of Biological Chemistry (2012)

Authors: 
Carnarius C., Kreir M., Krick M., Methfessel C., Moehrle V., Valerius O., Brüggemann A., Steinem C., Fertig N.

2012 - Effects of the Antitussive Drug Cloperastine on Ventricular Repolarization in Halothane-Anesthetized Guinea Pigs

icon pap   Port-a-Patch publication in Journal of Pharmacologigal Sciences (2012)

Authors: 
Takahara A., Fujiwara K., Ohtsuki A., Oka T., Namekata I., Tanaka H.

2012 - DNA unzipping and protein unfolding using nanopores

icon pap   Port-a-Patch publication in Methods of Molecular Biology (2012)

Authors: 
Merstorf C., Cressiot B., Pastoriza-Gallego M., Oukhaled A.G., Bacri L., Gierak J., Pelta J., Auvray L., Mathé J.

2012 - Design, synthesis and functional analysis of dansylated polytheonamide mimic: an artificial Peptide ion channel

icon pap   Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Journal of the American Chemical Society (2012)

Authors: 
Itoh H., Matsuoka S., Kreir M., Inoue M.

2012 - Calcium regulation by thermo- and osmosensing transient receptor potential vanilloid channels (TRPVs) in human conjunctival epithelial cells

icon pap   Port-a-Patch publication in Histochemistry and Cell Biology (2012)

Authors: 
Mergler S., Garreis F., Sahlmüller M., Lyras E.-M., Reinach P.S., Dwarakanath A., Paulsen F., Pleyer U.

2012 - Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation

icon pap   Port-a-Patch publication in PLoS ONE (2012)

Authors: 
Schwarz N., Drouot L., Nicke A., Fliegert R., Boyer O., Guse A.H., Haag F., Adriouch S., Koch-Nolte F.

2011 - Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Proceedings of the National Academy of Sciences of the United States (2011)

Authors: 
Shaya D., Kreir M., Robbins R.A., Wong S., Hammon J., Brüggemann A., Minor Jr. D.L.

2011 - Thermosensitive transient receptor potential channels in human corneal epithelial cells

icon pap   Port-a-Patch publication in Journal of Cellular Physiology (2011)

Authors: 
Mergler S., Garreis F., Sahlmüller M., Reinach P.S., Paulsen F., and Pleyer U.

2011 - State-of-the-art automated patch clamp devices: heat activation, action potentials, and high throughput in ion channel screening

icon pap   Port-a-Patch,   icon pl  Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) publication in Frontiers in Pharmacology (2011)

Authors: 
Stoelzle S., Obergrussberger A., Brüggemann A., Haarmann C., George M., Kettenhofen R., Fertig N.

2011 - Physiology of the Human Corneal Endothelium – New Insights from Electrophysiological Investigations

icon pap   Port-a-Patch publication in Klinische Monatsblätter für Augenheilkunde (2011)

Authors: 
Mergler S. and Pleyer U.

2011 - Functional Analysis of Synthetic Substructures of Polytheonamide B: A Transmembrane Channel-Forming Peptide

icon pap   Port-a-Patch publication in Angewandte Chemie International Edition (2011)

Authors: 
Matsuoka S., Shinohara N., Takahashi T., Iida M., Inoue M.

2011 - Chemical and biological characterization of four new linear cationic a-helical peptides from the venoms of two solitary eumenine wasps

icon pap   Port-a-Patch publication in Toxicon (2011)

Authors: 
Rangel M., dos Santos Cabrera M.P., Kazuma K., Ando K., Wang X., Kato M., Nihei K., HirataI.Y., Cross T.J., Garcia .N., Faquim-Mauro E.L., Franzolin M.R., Fuchino H., Mori-Yasumoto K., SekitaS., Kadowaki M., SatakeM., KonnoK.

2011 - Characterization of transient receptor potential vanilloid channel 4 (TRPV4) in human corneal endothelial cells

icon pap   Port-a-Patch publication in Experimental Eye Research (2011)

Authors: 
Mergler S., Valtink M., Taetz K., Sahlmüller M., Fels G., Reinach P.S., Engelmann K., Pleyer U.

2011 - Cardiac Toxicity

icon pl   Patchliner and   icon pap   Port-a-Patch book chapter in ADMET for Medicinal Chemists: A Practical Guide (2011)

Authors: 
Kettenhofen R., Schwengberg S.

2011 - Bacterial mechanosensitive channels as a paradigm for mechanosensory transduction

icon pap   Port-a-Patch publication in Cellular Physiology and Biochemistry (2011)

Authors:
Martinac B.

2011 - Automated Patch Clamp on mESC-Derived Cardiomyocytes for Cardiotoxicity Prediction

icon pl   Patchliner and   icon pap   Port-a-Patch publication in Journal of Biological Chemistry (2011)

Authors: 
Stoelzle S., Haythornthwaite A., Kettenhofen R., Kolossov E., Bohlen H., George M., Brüggemann A., Fertig N.

2010 - TRPV channels mediate temperature-sensing in human corneal endothelial cells

icon pap  Port-a-Patch publication in Experimental Eye Research (2010)

Authors: 
Mergler S., Valtink M., Coulson-Thomas V.J., Lindemann D., Reinach P.S., Engelmann K., Pleyer U.

2010 - Studying mechanosensitive ion channels using liposomes

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Methods in Molecular Biology (2010)

Authors: 
Martinac B., Rohde P.R., Battle A. R., Petrov E., Pal P, Alexander Foo A.FW, Vásquez V., Huynh T. and Kloda A.

2010 - Renaissance of ion channel research and drug discovery by patch clamp automation

icon pap  Port-a-Patch,   icon pl   Patchliner and   icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE)  publication in Future Medical Chemistry (2010)

Authors:
Farre C. and Fertig N.

2010 - Planar Patch Clamp Approach to Characterize Ionic Currents from Intact Lysosomes

icon pap  Port-a-Patch publication in Science Signaling (2010)

Authors:
Schieder M., Rötzer K., Brüggemann A., Biel M., Wahl-Schott C.

2010 - Permeation of antibiotics through escherichia coli OmpF and OmpC porins: screening for influx on a single-molecule level

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Journal of Biomolecular Screening (2010)

Authors: 
Mahendran K.R., Kreir M., Weingart H., Fertig N., Winterhalter M.

2010 - Cor.At Cardiomyocytes: Primary-like Cardiomyocytes for Manual and Automated Electrophysiological Screening

icon pap  Port-a-Patch and   icon pl   Patchliner publication in Lonza Resource Notes (2010)

Authors:
Kettenhofen R., Stölzle S.

2010 - Characterization of two pore channel 2 (TPCN2) -mediated Ca2+ currents in isolated lysosomes

icon pap  Port-a-Patch publication in The Journal of Biological Chemistry (2010)

Authors:
Schieder M., Rötzer K., Brüggemann A., Biel M., Wahl-Schott C.A.

2009 - Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases

icon pap  Port-a-Patch publication in FASEB (2009)

Authors:
Bessac B.F., Sivula M., von Hehn C.A., Caceres A.I., Escalera, J, Jordt S.

2009 - The M34A mutant of Connexin26 reveals active conductance states in pore-suspending membranes

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Journal of Structural Biology (2009)

Authors:
Gaßmann O., Kreir M., Ambrosi C., Pranskevich J., Oshima A, Röling C., Sosinsky G., Fertig N., Steinem C.

2009 - T-type channel blocking properties and antiabsence activity of two imidazo[1,2-b]pyridazine derivatives structurally related to indomethacin

icon pap  Port-a-Patch publication in Neuropharmacology (2009)

Authors: 
Rimoli M.G., Russo E., Cataldi M., Citraro R., Ambrosino P., Melisi D., Curcio A., De Lucia S., Patrignani P., De Sarro G., Abignente E.

2009 - Port-a-Patch and Patchliner: High fidelity electrophysiology for secondary screening and safety pharmacology

icon pap  Port-a-Patch and   icon pl   Patchliner publication in Combinatorial Chemistry & High Throughput Screening (2009)

Authors: 
Farre C., Haythornthwaite A., Haarmann C., Stoelzle S., Kreir M., George M., Brüggemann A., Fertig N.

2009 - Amyloid-beta-Induced Ion Flux in Artificial Lipid Bilayers and Neuronal Cells: Resolving a Controversy

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Neurotoxicity Research (2009)

Authors: 
Capone R., Quiroz F.G., Prangkio P., Saluja I., Sauer A.M., Bautista M.R., Turner R.S., Yang J., Mayer M.

2008 - TRPA1 is a major oxidant sensor in murine airway sensory neurons

icon pap  Port-a-Patch publication in The Journal of Clinical Investigation (2008)

Authors: 
Bessac B.F., Sivula M., von Hehn C.A., Escalera J., Cohn L., Jordt S.E.

2008 - Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3

icon pap  Port-a-Patch publication in Bioorganic & Medicinal Chemistry Letters (2008)

Authors: 
Cianci J., Baell J.B., Flynn B.L., Gable R.W., Mould J.A., Paul D., Harvey A.J.

2008 - Rapid screening of membrane protein activity: electrophysiological analysis of OmpF reconstituted in proteoliposomes

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Lab-on-a-chip (2008)

Authors: 
Kreir M., Farre C., Beckler M., George M., Fertig N.

2008 - Planar patch-clamp force microscopy on living cells

icon pap  Port-a-Patch publication in Ultramicroscopy (2008)

Authors: 
Pamir E., George M., Fertig N., Benoit M.

2008 - Planar patch clamp: Advances in electrophysiology

icon pap  Port-a-Patch book chapter in "Potassium Channels" (2008)

Authors: 
Brüggemann A., Farre C., Haarmann C., Haythornthwaite A., Kreir M., Stoelzle S., George M., Fertig N.

2008 - Ion channel screening – automated patch clamp on the rise

icon pap  Port-a-Patch and   icon pl   Patchliner publication in Drug Discovery Today (2008)

Authors: 
Farre C., George M., Brüggemann A., Fertig N.

2008 - High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology

icon pap  Port-a-Patch publication in Nature Reviews Drug Discovery (2008)

Authors: 
Dunlop J., Bowlby M., Peri R., Vasilyev D., Arias R.

2007 - Planar Patch Clamping

icon pap  Port-a-Patch and   icon pl   Patchliner book chapter in "Patch Clamp Analysis – Advanced Techniques", Series: Neuromethods (2007)

Authors: 
Behrends, J.C., Fertig, N.

2007 - Electrophysiological assessment of HERG blockade: Comparative study using automated and conventional patch clamp systems

icon pap  Port-a-Patch publication in Toxicological Letters (2007)

Authors: 
Yook Y., Kim J., Cho H., Moon H., Kwak B.

2007 - Automated ion channel screening: patch clamping made easy

icon pap  Port-a-Patch and   icon pl   Patchliner publication in Expert Opinion Therapeutic Targets (2007)

Authors: 
Farre C., Stoelzle S., Haarman C., George M., Brueggemann A., Fertig N.

2006 - Microchip technology for automated and parallel patch clamp recording

icon pap  Port-a-Patch and   icon pl   Patchliner publication in Small Journal (2006)

Authors: 
Brüggemann A., Stoelzle S., George M., Behrends J.C., Fertig N.

2006 - High-resolution electrophysiology on a chip: Transient dynamics of alamethicin channel formation

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Biochimica et Biophysica Acta - Biomembranes (2006)

Authors: 
Sondermann M., George M., Fertig N., Behrends J.C.

2005 - The Port-a-Patch: The smallest patch clamp set up for high quality electrophysiology

icon pap  Port-a-Patch publication in HEKA Impulse (2005)

Authors: 
Brüggemann A., George M., Klau M., Beckler M., Steindl J., Behrends J., Fertig N.

2005 - Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles

icon pap  Port-a-Patch publication in Nano Letters (2005)

Authors: 
Kirchner C., Liedl T., Kudera S., Pellegrino T., Munoz J. A., Gaub H.E., Stoelzle S., Fertig N., Parak W.J.

2004 - Ion channel drug discovery and research: The automated Nano-Patch-Clamp technology

icon pap  Port-a-Patch publication in Current Drug Discovery Technologies (2004)

Authors: 
Brüggemann A., George M., Klau M., Beckler M., Steindl J., Behrends J.C., Fertig N.

2003 - Simultaneous optical and electrical recording of single gramicidin channels

icon pap  Port-a-Patch publication in Biophysical Journal (2003)

Authors: 
Borisenko V., Lougheed L., Hesse J., Fuereder-Kitzmueller E., Fertig N., Behrends, J.C., Woolley G.A., Schuetz G.J.

2003 - Microstructured apertures in planar glass substrates for ion channel research

icon pap  Port-a-Patch publication in Channels and Receptors (2003)

Authors: 
Fertig N., Meyer C., Tilke A., George M., Klau M., Sobotta C., Blick R.H., Behrends J.C.

2003 - Lighting up single ion channels

icon pap  Port-a-Patch publication in Biophysical Journal (2003)

Authors: 
Selvin P.R.

2003 - High quality ion channel analysis on a chip with the NPC-technology

icon pap  Port-a-Patch publication in Assay and Drug Development Technologies (2003)

Authors: 
Brüggemann A., George M., Klau M., Beckler M., Steindl J., Behrends J.C., Fertig N.

2002 - Whole cell patch clamp recording performed on a planar glass chip

icon pap  Port-a-Patch publication in Biophysical Journal (2002)

Authors: 
Fertig N., Blick R.H., Behrends J.C

2002 - Patch clamp on a chip

icon pap  Port-a-Patch publication in Biophysical Journal (2002)

Authors: 
Sigworth F.J., Klemic K.G.

2002 - Activity of single ion channel proteins detected with a planar microstructure

icon pap  Port-a-Patch publication in Applied Physics Letters (2002)

Authors: 
Fertig N., Klau M., George M., Blick R.H., Behrends J.C.

2001 - Microstructured glass chip for ion channel electrophysiology

icon pap  Port-a-Patch publication in Physical review. E, Statistical, nonlinear, and soft matter physics (2001)

Authors: 
Fertig N., Meyer C., Blick R.H., Trautmann C., Behrends J.C.

2000 - Stable integration of isolated cell membrane patches in a nanomachined aperture

icon pap  Port-a-Patch publication in Applied Physics Letters (2000)

Authors: 
Fertig N., Tilke A., Blick R.H., Kotthaus J.P., Behrends J.C., ten Bruggencate G.

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