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2006 - Transporter assays using solid supported membranes: a novel screening platform for drug discovery

Icon N1   SURFE²R ONE (a predecessor model of SURFE²R N1) publication in ASSAY and Drug Development Technologies (2006)

Authors:
Kelety B., Diekert K., Tobien J., Watzke N., Dörner W., Obrdlik P., Fendler K.

Journal:
ASSAY and Drug Development Technologies (2006) 4(5):575-582


Abstract:

Transporters are important targets in drug discovery. However, high throughput-capable assays for this class of membrane proteins are still missing. Here we present a novel drug discovery platform technology based on solid supported membranes. The functional principles of the technology are described, and a sample selection of transporter assays is discussed: the H+-dependent peptide transporter PepT1, the gastric proton pump, and the Na+/Ca2+ exchanger. This technology promises to have an important impact on the drug discovery process.


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