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    Nanion Technologies: イオンチャネル研究のスマートツール

  • SyncroPatch 384i: HTS Automated Patch Clamp

    SyncroPatch 384i: HTS Automated Patch Clamp

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    SURFE²R 96SE: ラベルフリーのトランスポーターHTS

  • Dynamic Clamp: Patchliner

    Dynamic Clamp: Patchliner

  • 脂質二分子膜実験: Orbitシリーズ

    脂質二分子膜実験: Orbitシリーズ

  • CardioExcyte 96 SOL: 心筋の光ペーシング

    CardioExcyte 96 SOL: 心筋の光ペーシング

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SyncroPatch 384

SyncroPatch 384

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Orbit 16 TC

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Orbit Mini

Vesicle Prep Pro

Vesicle Prep Pro

2020 - Unattended Screening Workflow in a 384-well Automated Patch Clamp System

 icon sp96   SyncroPatch 384i (a predecessor model of SyncroPatch 384) poster, SPS 2020   logo pdf   (1.3 MB)

Abstract:

Within ion channel working group efforts (Fermini et al., 2015), reference compounds were tested across multiple sites and automated patch clamp (APC) platforms (Kramer et al., 2020). Resulting IC50 values were variable between drugs and platforms. In general, as Iversen et al. (2012) outlined, the quality of an assay is defined by the robustness and reproducibility of the measurement signal in the absence of any test compounds. Data robustness and reliability using an APC instrumentation should be proven carefully before an unattended full-day screening workflow is implemented.

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