2020 - Mechanical Stimulation in a 2D High-Throughput Contractility System Induces Functional Changes in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes
FLEXcyte 96 poster, Safety Pharmacology Society Virtual Meeting 2020 (1 MB)
The use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSCCMs)to assess efficacy and cardiac safety of new drug candidates continues to increase. In this context, a new 2D high-throughput system, FLEXcyte 96, allows for contractility measurements of cells cultured in a more physiological environment, reflecting the mechanical conditions of the native human heart. This study aims to show the influence of mechanical stimulation on functional behavior of hiPSC-CMs. This aspect is of particular importance, as mechanical load acts as crucial growth regulator in the developing heart.
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