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2020 - Mechanical Stimulation in a 2D High-Throughput Contractility System Induces Functional Changes in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes

 Icon CE   FLEXcyte 96 poster, Safety Pharmacology Society Virtual Meeting 2020   logo pdf   (1 MB)

Abstract:

The use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSCCMs)to assess efficacy and cardiac safety of new drug candidates continues to increase. In this context, a new 2D high-throughput system, FLEXcyte 96, allows for contractility measurements of cells cultured in a more physiological environment, reflecting the mechanical conditions of the native human heart. This study aims to show the influence of mechanical stimulation on functional behavior of hiPSC-CMs. This aspect is of particular importance, as mechanical load acts as crucial growth regulator in the developing heart.

Listen to the narrated version:




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