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2021 - Fluorescent- and tagged-protoxin II peptides: potent markers of the Nav1.7 channel pain target

icon sp96SyncroPatch 384PE (a predecessor model of the SyncroPatch 384 instrument) Publication in British Journal of Pharmacological (2021)

Authors:
Montnach J., De Waard S., Nicolas S., Burel S., Osorio N., Zoukimian C., Mantegazza M., Boukaiba R., Béroud R., Partiseti M., Delmas P., Marionneau C., De Waard M.

Journal:
British Journal of Pharmacological (2021) doi:10.1111/bph.15453


Abstract:

Protoxin II (ProTx II) is a high affinity gating modifier that is thought to selectively block the Nav1.7 voltage-dependent Na+ channel, a major therapeutic target for the control of pain. We aimed at producing ProTx II analogues entitled with novel functionalities for cell distribution studies and biochemical characterization of its Nav channel targets.


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