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2021 - Modeling of ion channels - A side by side comparison between Hodgkin Huxley and hidden Markov approach on the example of Kv1.1

icon pl  Patchliner Publication in Verlag der Technischen Universität Graz (2021)

Authors:
Langthaler S., Rienmüller T. M., Lozanovic Sajic J., Baumgartner C.

Journal:
Verlag der Technischen Universität Graz (2021) doi:10.3217/978-3-85125-826-4-04


Abstract: 

Mathematical models of individual ion channels form the building blocks of complex in-silico tools, enabling the investigation of biophysical mechanisms and simulation of disease processes. We here propose a first simplified hidden Markov Model (HMM) for the voltage-gated potassium channel Kv1.1, taking into account the channels’ specific activation and inactivation characteristics close to physiological temperature. The modeling approach and simulation results were compared with an existing Hodgkin Huxley model based on the same experimental data. The newly developed HMM shows a higher accuracy with regard to the activation and inactivation behavior com- pared to the Hodgkin Huxley approach.


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