Kir2.1 | Potassium Voltage-Gated Channel Subfamily J Member 2
Family:
Inward-rectifier potassium ion channel
Subgroups:
Seven families channels demonstrate robust inward rectification: Kir1.1; Kir2.1 - Kir2.4; Kir3.1 - Kir3.4, Kir4.1 - Kir4.2; Kir5.1, Kir6.1 - Kir6.2; Kir7.1
Topology:
The channel protein contains two membrane spanning alpha helices denoted as M1 and M2. Four identical subunits form a functional homotetramer, heterotetramers can combine with members of the same subfamily
Kir2.1 Background Information
Kir2.1 is a inward rectifier potassium channel which participates in establishing action potential waveform and excitability of neuronal and muscle tissues.
Gene:
KCNJ2
Human Protein:
UniProt P63252
Tissue:
Heart, peripheral nerves, brain, vascular smooth muscle cells, skeletal muscles, lung, placenta, kidney
Function/ Application:
Participates in establishing action potential waveform and excitability of neuronal and muscle tissues, mediates the IK1 current in the heart
Pathology:
Andersen-Tawil syndrome, Short QT syndrome 3, Autosomal dominant inheritance, Bidirectional ventricular ectopy, Blepharophimosis, Brachydactyly syndrome, Long QT syndrome 7 (LQT7), Atrial fibrillation familial, 9 (ATFB9), PiP2
Interaction:
Forms heterodimers with Kir2.2 and Kir4.1. Interacts with Kir2.3, DLG4, DLG1, CASK, APBA1, interleukin 16, TRAK2, LIN7A, LIN7B, LIN7C, AKAP5
Modulator:
Glyburide, Nicorandil, Cesium chloride, Tertiapin-Q, Glibenclamide, ML 133 hydrochloride, Barium chloride
Assays:
Patch clamp
Recommended Reviews:
Kubo et al. (2005) International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels. Pharmacol Rev 57(4):509-526