KV1.3 | Shaker Related Potassium Channel Member 3
Shaker (KV1.1–KV1.8), Shab (KV2.1-KV2.2), Shaw (KV3.1–KV3.4), Shal (KV4.1–KV4.3), KQT like (KV7.1–KV7.5), Eag related (KV10.1-KV10.2), Erg related (KV11.1–KV11.3), Elk related (KV12.1)
Contains six transmembrane domains (S1–S6), four single subunits form a pore, homotetramers and heterotetramers are possible.
KV1.3 Background Information
KV1.3 belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. KV1.3 is expressed in T and B lymphocytes and plays an essential role in T cell proliferation and activation. Blockade of KV1.3 channels in effector-memory T cells suppresses calcium signaling, cytokine production (interferon-gamma, interleukin 2) and cell proliferation. KV1.3 is an important target for drug development for autoimmune diseases as Multiple Sclerosis, type-1 diabetes mellitus and rheumatoid arthritis.
brain, lung, osteoclasts, T-lymphocytes, B-lymphocytes
T-lymphocyte activation, apoptosis, proliferation
Immune response, multiple sclerosis, rheumatoid arthritis, diabetes mellitus, asthma, cancer
KVβ2, β1 Integrin, SAP97, ZIP
PAP-1, Margatoxin, Noxiustoxin, Charybdotoxin
Patch Clamp: whole cell, room temperature, physiological temperature, State- and use-dependence / site of action
Gutman et al. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57(4):473-508