NaV1.7| sodium voltage-gated channel alpha subunit 9
Alpha subunits consist of four homologous domains (I-IV) with six transmembrane alpha helices (S1–S6) and a pore-forming loop. One a subunit may associate with 1 or 2 b subunits to make up the channel.
NaV1.7: Background Information
NaV1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. The NaV1.7 channel produces a rapidly activating and inactivating current which is sensitive to the level of tetrodotoxin. It is usually expressed at high levels in two types of neurons, the nociceptive (pain) neurons at dorsal root ganglion (DRG) and trigeminal ganglion, and sympathetic ganglion neurons, which are part of the autonomic (involuntary) nervous system.
Sensory neurons, smooth myocytes, myenteric neurons, erythroid progenitor cells, immune cells, Schwann cells
Nociception signalling, sensory neuron excitability
Erythermalgia (IEM, PERYTHM), pain (CIP, PEPD), anosmia, epilepsy (GEFSP7), cancer
NGF, NEDD4, NEDD4L, calmodulin
Tetrodotoxin, α-scorpion toxin, lidocaine
Patch Clamp: whole cell, room temperature, State- and use-dependence
NaV channel analysis requires GigaOhm seals and a stable and low access resistance
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels. Pharmacol Rev 57: 397–409, Catterall, et al. 2005
Data and Applications
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