NaV1.9 | sodium voltage-gated channel alpha subunit 11
Alpha subunits consist of four homologous domains (I-IV) with six transmembrane alpha helices (S1–S6) and a pore-forming loop. One a subunit may associate with 1 or 2 b subunits to make up the channel.
NaV1.9: Background Information
NaV1.9 is largely expressed in small-diameter nociceptors of the dorsal root ganglion and trigeminal ganglion neurons, but is also found in intrinsic myenteric neurons. Like Nav1.7 and Nav1.8, Nav1.9 plays a role in pain perception, having been linked to the perception of inflammatory, neuropathic, and cold-related pain. It does this primarily through its ability to lower the threshold potential of the neuron, allowing for an increase in action potential firing that leads to hyperexcitability of the neuron and increased pain perception.This channel NaV1.9 is a TTX-resistant sodium channel.
Brain, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, small intestine, spleen, testis, bladder, and placenta
Excitability of neurons (lowering the threshold potential), nociceptive transmission
Episodic pain syndrome, familial, 3 (FEPS3), Pathogenic Neuropathy hereditary sensory and autonomic 7 (HSAN7), Diarrhea, Dysautonomia, Hyperhidrosis
Accessory subunits:SCN1B, SCN2B and SCN3B
Calmodulin 1, Calmodulin 2, Calmodulin 3, spectrin, Neurofascin, CACNA1H, CACNA1I, Kinesin Family Member 5C, Ryanodine Receptor 1, Ryanodine Receptor 2
Tetracaine, Nifedipine, Carbamazepine, Vinpocetine, Amiloride hydrochloride
Patch Clamp: whole cell, perforated patch
NaV channel analysis requires GigaOhm seals and a stable and low access resistance
Recommended Reviews:International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels. Pharmacol Rev 57: 397–409, Catterall, et al. 2005
Data and Applications
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