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03.04.2020: Webinar announcement (April 28): Ca2+ channel assays

On the 28th of April we continue our Webinar-Series with a talk from Dr. Mark Rogers and Dr. András Horváth:

"Validation and optimization of automated patch clamp voltage-gated Ca2+ channel assays"

Date: 28. April 2020

Time: 4:00 PM CET / 10:00 AM EDT

Register here 


Dr. Marc Rogers (CSO, Metrion Biosciences)

Dr. András Horváth (Application Scientist, Nanion Technologies)


"Marc will outline the development, optimization and validation of a range of voltage-gated Ca2+ channel assays on the Patchliner automated patch clamp platform that were subsequently used in an 8 year drug discovery collaboration between Metrion Biosciences and a german pharma company. The project was successful in identifying several lead series of selective,state-dependent inhibitors of Cav2.2 N-type channels for use as novel, non-opioid analgesic. This required the creation of biophysical screening assays to identify the potency of small molecules against the resting and inactivated state of the human neuronal Ca2+ channels Cav2.1(P/Q type), Cav2.2 and Cav3.2 (T-type), some of which are notoriously difficult in terms of expression levels and current rundown."


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