18.09.2020: Free Application Note - Activation and Inhibition of TASK-1
Activation and Inhibition of TASK-1 on Nanion’s SyncroPatch 384PE
What you will learn:
- We demonstrate recordings of human TASK-1 expressed in HEK cells on the SyncroPatch 384PE with good success rates.
- K2P channels are characterized by the presence of two pore forming regions and four trans-membrane spanning (4TMS) regions in each channel subunit and form functional dimers.
- These channels are essential for the production of background leak type potassium currents that act to regulate resting membrane potential and levels of cellular excitability
- TASK-1 has been implicated in atrial fibrillation (AF) pathophysiology and was suggested as an atrial-selective antiarrhythmic drug target.