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18.09.2020: Free Application Note - Activation and Inhibition of TASK-1

Activation and Inhibition of TASK-1 on Nanion’s SyncroPatch 384PE

What you will learn:

  • We demonstrate recordings of human TASK-1 expressed in HEK cells on the SyncroPatch 384PE with good success rates.
  • K2P channels are characterized by the presence of two pore forming regions and four trans-membrane spanning (4TMS) regions in each channel subunit and form functional dimers.
  • These channels are essential for the production of background leak type potassium currents that act to regulate resting membrane potential and levels of cellular excitability
  • TASK-1 has been implicated in atrial fibrillation (AF) pathophysiology and was suggested as an atrial-selective antiarrhythmic drug target.

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