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01.10.2020 - Free Application Note - Human a7 nicotinic Acetylcholine Receptor

Human a7 nicotinic Acetylcholine Receptor on the Patchliner

Abstract:
The nicotinic acetylcholine receptor (nAChR) is a member of the ligand-gated ion channel superfamily which includes GABAA, 5HT3, NMDA and glycine receptors. It is a cation-permeable ion channel activated by the neurotransmitter acetylcholine and the natural alkaloid, nicotine. Neuronal nAChR are pentameric and functional channels are formed from a repertoire of nine α (α2 to α10) and three β subunits (β2 to β4). Most nAChR exist as heteromers with the stoichiometry 2α to 3β, however some α subunits function as homomers, these being α7 or α9 (for reviews see Refs. 1 & 2). nAChR have been proposed to play a role in many neurological disorders such as Alzheimer’s Disease, Parkinson’s, schizophrenia and depression. nAChα7R are widely distributed in the mammalian brain including in the cerebral cortex, hippocampus, basal ganglia and cerebellum4. There is evidence that nAChα7R play a role in cognition and could be a potential therapeutic target in cognitive disorders such as Alzheimer’s Disease or schizophrenia.

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