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08.01.2021: Poster - High content in vitro cell monitoring effects of adjuvant chemotherapy in breast cancer and cancer treatment-related cardiomyopathy

High content in vitro cell monitoring effects of adjuvant chemotherapy in breast cancer and cancer treatment-related cardiomyopathy

Abstract

Impedance changes of cell-covered electrodes give profound insight into cell proliferation and contractility, even over prolonged time periods, providing significant advantage over standard mostly endpoint cytotoxicity assays. Here, this technology was used for monitoring cell regrowth in breast cancer, after chemotherapy treatment in vitro. As the emerging field of cardio-oncology aims to find a balance between oncologic efficacy and reducing adverse cardiovascular effects, we tested the same treatment on induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). One of the standard clinical regimens for breast cancer is a combination of cyclophosphamide, adriamycin (doxorubicin) and 5-fluorouracil (CAF) administered for 4 months. Even though initially successful, tumor recurrence after this therapy remains a major cause of mortality in breast cancer patients, leaving the need for better treatment. 

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