22.01.2021 - A deep-dive into Piezo1
Piezo1
Members:
Piezo1 and Piezo2 in vertebrates, encoded by PIEZO1 and PIEZO2 genes, respectively.
Topology:
Piezo 1 is a trimeric mechanosensitive ion channel. Piezos are very large proteins with numerous (>14) predicted transmembrane (TM) domains per subunit.
Regulation and Function:
Piezo1 opens in response to mechanical stimuli such as shear stress and membrane stretch, allowing positively charged ions, including calcium, to flow into the cell.