17. March 2020 - FLEXcyte 96
"A new technology to evaluate mature cardiac contractility on highthroughput level"
Date: 17. March 2020
Time: 4:00 PM CET / 10:00 AM EST
Speakers:
Dr. Sonja Stölzle-Feix (Director, Scientific Affairs, Nanion Technologies)
Dr. Matthias Gossmann (Co-Founder and CEO, innoVitro GmbH)
Abstract:
Drug development is a costly and time-consuming process, with high drug failure rates both in early and late stages of the development process. Pre-clinical cardiac safety, toxicity and efficacy testing, usually performed using animal models with low predictive value or primary human cells, are one of the main reasons for high drug attrition rates.
To improve the drug development process, a suitable technology is required to acquire high quality data from physiologically relevant models on high throughput level. Standard cultivation methods for stem cell-derived cardiomyocytes are still based on stiff glass or plastic surfaces, creating an unphysiological environment to what cells would experience naturally and hinder them to further mature in vitro. In contrast, the FLEXcyte 96 plates mimic flexible mechanical conditions of real biological tissue and thereby enhancing the development of a mature cardiomyocyte phenotype which cannot be elicited with other assays commonly used. In combination with the FLEXcyte 96 platform, it is possible to analyze mature cardiac contractility on a 96 well high throughput level, both after acute and chronic compound treatment, ranging from 5 minutes to 5 days.
Hence, the FLEXcyte 96 system enables high throughput at lower costs and delivers highly predictive functional information on drug candidates early in the drug development process.
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SyncroPatch 384PE (a predecessor model of SyncroPatch 384i), 
Patchliner, 
Port-a-Patch Webinar
CardioExcyte 96, 
FLEXcyte 96, 
Orbit mini and 
Orbit 16
This webinar covers the use of the lipid bilayer platforms from Nanion: the Orbit16 and the Orbit mini for characterization of membrane proteins like ion channels, bacterial porins and biological nanopores. Both bilayer systems support high quality low noise recordings, but differ in throughput capabilities and experimental features. The Orbit16, introduced in 2012 is a device for efficient formation of 16 lipid bilayers simultaneously, allowing for parallel bilayer-reconstitution of ion channels and nanopores.
SURFE²R 96SE and 
SURFE²R N1