• CardioExcyte 96

    インピーダンス&細胞外電位のハイブリッド測定
  • CardioExcyte 96

    心臓安全性スクリーニングに最適
  • CardioExcyte 96

    ラベルフリー:次世代の細胞解析
  • CardioExcyte 96

    直感的にデータ解析可能 & 不整脈の検出

Cardiac Ion Channels - Pharmacology of Sotalol

CiPA PE CE Pharmacology SotalolIcon CE    CardioExcyte 96 and   icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) data and applications:
Cells were kindly provided by Charles River and Cellular Dynamics.

The image on the left hand side displays the results of the blocking effect of Sotalol on hERG. The result is in good agreement with manual patch clamp data (Crumb et al., 2016). The compound induced arrhythmia when iPSC-CM were exposed to a minimum concentration of 10 µM. Arrhytmic events were both detected in field potential recordings as well as in the impedance based contractility measurements.

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