• CardioExcyte 96

    インピーダンス&細胞外電位のハイブリッド測定
  • CardioExcyte 96

    心臓安全性スクリーニングに最適
  • CardioExcyte 96

    ラベルフリー:次世代の細胞解析
  • CardioExcyte 96

    直感的にデータ解析可能 & 不整脈の検出

2020 - Molecular Profiling of Human Induced Pluripotent Stem Cell-Derived Cells and their Application for Drug Safety Study

Icon CE   CardioExcyte 96 Review in Current Pharmaceutical Biotechnology (2020)

Authors:
Matsui T., Miyamoto N., Saito F., Shinozawa T.

Journal:
Current Pharmaceutical Biotechnology (2020)  doi: 10.2174/1389201021666200422090952


Abstract:

Drug-induced toxicity remains one of the leading causes of discontinuation of the drug candidate and post-marketing withdrawal. Thus, early identification of the drug candidates with the potential for toxicity is crucial in the drug development process. With the recent discovery of humanInduced Pluripotent Stem Cells (iPSC) and the establishment of the differentiation protocol of human iPSC into the cell types of interest, the differentiated cells from human iPSC have garnered much attention because of their potential applicability in toxicity evaluation as well as drug screening, disease modeling and cell therapy. In this review, we expanded on current information regarding the feasibility of human iPSC-derived cells for the evaluation of drug-induced toxicity with a focus on human iPSCderived hepatocyte (iPSC-Hep), cardiomyocyte (iPSC-CMs) and neurons (iPSC-Neurons). Further, we CSAHi, Consortium for Safety Assessment using Human iPS Cells, reported our gene expression profiling data with DNA microarray using commercially available human iPSC-derived cells (iPSC-Hep, iPSC-CMs, iPSC-Neurons), their relevant human tissues and primary cultured human cells to discuss the future direction of the three types of human iPSC-derived cells.


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