• Patchliner

    最高の実験柔軟性を誇るオートパッチ
  • Patchliner

    チップの自社内製造と厳格なQC
  • Patchliner

    10年以上のアッセイ系構築/サポート実績
  • Dynamite8

    Automated Dynamic Clamp
  • Patchliner

    マニュアルパッチの優位性を全て継承

KCNQ1/KCNE1 - block by Chromanol 293B

IKs PL Chromanolicon pl   Patchliner data and applications: 
Data kindly provided by ApconiX, UK

KCNQ1/KCNE1 expressed in CHO cells was activated using a 2 s voltage step to 40 mV and blocked by increasing concentrations of chromanol 293B.  Shown are traces from an example cell in the absence and presence of chromanol 293B and the normalized concentration response curve for an average of 6 cells. The curve was fit with a Hill equation revealing an IC50 = 2.8 ± 0.9 μM (n = 6). 

 

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