PhD position – INNOVATION Doctoral Network ,
Nanion and the INNOVATION DN
INNOVATION (Ion channels in erythrocytes: A novel understanding from regulation of erythropoiesis and physiological function to diagnostic measures and therapeutic concepts) is a MSCA Doctoral Network (DN) characterized by eight academic and non-academic beneficiaries from four different countries (France, Germany, Italy, and The Netherlands), collaborating on the common goal of elucidating the multifaceted characteristics of ion channels and their function in red blood cells (RBCs).
As a partner in the INNOVATION consortium, Nanion will contribute to characterizing the ion channel profile of native and artificial RBCs. In the predecessor Innovative Training Networks, RELEVANCE and EVIDENCE, Nanion has established its technology as a robust tool to investigate PIEZO1 (Rotordam et al., 2018; Karamatic Crew et al., 2023), Gárdos (Buks et al., 2021) and TRPV2 (Flormann et al., 2022) channels in healthy and mutated RBCs. This approach will be extended to the investigation of other ion channels (CaV 2.1, NMDA receptors, chloride channels, etc.), and applied to RBC precursors, e.g. erythroblasts and reticulocytes, where ion channels are expressed in a larger number of copies compared to mature RBCs. The resulting ion channel profile of healthy RBCs will give insights on the role of ion channels in RBC maturation and help the functional characterization of variant of unknown significance (VUS) mutations, with the goal of providing the basis for the search of potential drug targets.