News

The lysosomal ion channel TRPML1 plays a key role in autophagy, calcium signaling, and membrane trafficking, making it a compelling target for therapeutic development in lysosomal storage and neurodegenerative disorders. A recent study from Astex Pharmaceuticals and collaborators showcases a robust high-throughput cryo-EM workflow developed for TRPML1, enabling detailed structural and functional analysis of this […]

Cancer remains one of the most prevalent and lethal diseases globally. Liquid tumor (hematological cancer) cell lines are vital in studying blood cancers and developing therapies. Immunotherapy, particularly chimeric antigen receptor (CAR) T-cell therapy, has shown great promise, improving outcomes in hematological malignancies. Since 2017, the FDA has approved six CAR T-cell therapies for blood […]

Mutations in the GABA transporter GAT-1 (SLC6A1) are known to cause developmental and epileptic disorders but not all mutations are created equal. A new study takes a deep dive into two epilepsy-linked substitutions at glycine 443 (G443), a residue conserved across the entire SLC6 family. The variants G443D and G443V were both found to abolish […]

When? June 30 – July 2, 2025
Where? Sophia Antipolis – France

When? July 7-9, 2025
Where? University of Barcelona, University Zone, Faculty of pharmacy.

When? July 8-10, 2025
Where? 320 E Superior Street, Chicago, IL 60611, USA

When: July 17 – 18, 2025
Where: Tokyo, Japan

When? July 23-26, 2025
Where? Exhibit area at the Marriott Baltimore Waterfront

In this latest blog, Marc Rogers reviews the current status and future potential of ion channel gene therapies — from gene replacement and editing to RNA-based methods that modulate channel expression. These approaches are now being applied to a broad range of therapeutic areas including pain, epilepsy, cystic fibrosis, and retinal diseases. After academic research […]

Organellar ion channels, residing in lysosomes, endosomes, mitochondria, the endoplasmic reticulum (ER), and Golgi apparatus, are now recognized as critical regulators of calcium signaling, ionic homeostasis, and autophagy. Their dysfunction is increasingly linked to neurodegenerative diseases, cancer, infectious disease, and metabolic syndromes. Despite their importance, these intracellular channels have historically been difficult to study. In this […]

Date: September 24, 2025
Time: 16:00 – 17:00 CEST
Location: Online via Zoom

When: 28.10. – 29.10.2025
Venue: Ganghoferstraße 66b, 80339 München

At Nanion, we know how tough, and exciting the early stages of a research career can be. That’s why we’re committed to supporting young scientists not just with tools, but with opportunities to show up, share your work, and be seen. Recently, we had the privilege to do just that: Best Poster Award – CLCN4 […]

The epithelial sodium channel (ENaC) plays a central role in regulating sodium balance, blood pressure, and pulmonary fluid clearance. Despite its clinical relevance, progress in discovering new ENaC-targeting drugs has been limited by the lack of efficient, scalable functional assays. In a recent study, researchers developed and validated an automated patch clamp (APC) approach using […]

When? June 12-14, 2025
Where? Catania, Italy

When? June 23-26, 2025
Where? Château Belmont, 57 rue Groison, 37100 Tours, France

Date: June 18, 2025
Time: 16:00 – 17:00 CEST
Location: Online via Zoom

Nanion Technologies Japan is excited to announce the relocation of its office and laboratory to the University of Tokyo, marking an important step in strengthening scientific collaboration and expanding our presence in Japan.   Accelerating research At Nanion, we are committed to supporting the scientific community with state‑of‑the‑art instrumentation and expertise. By moving to the […]

Synthetic auxin herbicides like 2,4-dichlorophenoxyacetic acid (2,4-D) are widely used in agriculture to control dicot weeds, yet the identity of their transporters in plant cells has remained unresolved. While natural auxins – such as indole-3-acetic acid (IAA), key phytohormones that regulate plant growth and development – are known to be transported by PIN-FORMED (PIN) auxin […]

Date: June 12 2025
Time: 16:00 h CEST

When? June 3-6, 2025
Where? Bailey Allen Hall, Aras na MacLeinn Upper Newcastle, Galway, H91 TK33, Ireland.

We’re excited to be part of the 5th European Calcium Channel Conference (ECCC)! When? May 26-30, 2025 Where? Congress Centrum Alpbach,Alpbach 246, 6236 Alpbach, Austria Visit the conference website to learn more

We’re excited to be part of the FEBS Advanced Lecture Course “Emerging Insights from Structural Biology into Molecular Mechanisms of Diseases” When? May 27-31, 2025 Where? Hotel Flonk Groningen Zuid, Visit the conference website to learn more

Why does the sodium/proton exchanger NHE9 only function inside cells, and not at the plasma membrane? Na⁺/H⁺ exchangers (NHEs) play a central role in maintaining pH balance, sodium gradients, and overall cell function. While much is known about plasma membrane isoforms like NHE1, intracellular variants such as NHE9 have remained more elusive. One key question […]

Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) are a widely used platform in cardiac research. They offer a patient-specific model for investigating disease mechanisms, cardiotoxicity, and drug responses. However, their structural and functional immaturity remains a significant limitation, particularly for applications requiring adult-like electrophysiological behavior. A recent study by Wener Li and colleagues (Technische Universität […]

How do membrane lipids contribute to the structure and function of protein pores? A new study from the National Institute of Chemistry in Slovenia offers detailed insights using cryo-electron microscopy (cryo-EM), molecular dynamics simulations, and electrophysiology. The researchers investigated Fav, a pore-forming toxin from the coral Orbicella faveolata. In this study, it revealed unexpected structural […]

Date: May 8, 2025
Time: 16:00 – 17:00 CEST
Location: Online via Zoom

Date: May 14, 2025
Time: 16:00 – 17:00 CEST
Location: Online via Zoom

When: 21.05.2025 Venue: Virtual symposium    

We’re excited to be part of the Cambridge Ion Channel Forum (CICF) 2025! When? May 15, 2025 Where? The Discovery Centre (DISC), AstraZeneca Cambridge, Biomedical Campus, 1 Francis Crick Ave, Trumpington, Cambridge, CB2 0AA, UK. Visit the conference website to learn more

The Membrane Physiology Symposium hosted by Nanion Technologies will take place in Napa Valley California at the Meritage Resort & Spa. This event will include a diverse range of research covered by established leaders in their fields, collaborative interactions, multiple networking sessions, a variety of great sponsors, great food, and Napa Valley’s famous wines.

Animal venom peptides like charybdotoxin (ChTx) are known for their high specificity and potency as potassium channel blockers, making them valuable tools in ion channel research. However, achieving precise spatial and temporal control over their activity remains challenging. While photoswitchable small molecules have been successfully developed, incorporating such technology into larger peptides has been hindered […]

Channelrhodopsins (ChRs) are light-sensitive ion channels widely used in optogenetics to precisely control neuronal and cardiac activity. While most ChRs conduct cations non-selectively, a specialized subgroup – potassium-selective channelrhodopsins (KCRs) – preferentially transport K⁺ ions, making them promising tools for hyperpolarizing neurons and silencing action potentials. However, the precise molecular mechanism by which KCRs open […]

We’re thrilled to announce that Nanion Technologies will be participating in the Montpellier Electrophysiology School (E2M) 2025, a premier training program designed to equip researchers with theoretical and practical knowledge in electrophysiology. When? March 26–28, 2025 Where? Montpellier, France Visit the conference website to learn more

We are looking forward to meeting you at Stem cell models of neurodegeneration symposium. When? March 26–28, 2025 Where? John McIntyre Conference Centre Pollock Halls, 18 Holyrood Park Road Edinburgh, EH16 5AY, UK Visit the conference website to learn more Book a meeting with us during the symposium

We are looking forward to meeting you at Stem cell models of neurodegeneration symposium. When? March 27–28, 2025 Where?Institut für Physiologie II Hörsaal Robert-Koch-Straße 27b 48149 Münster Deutschland Visit the conference website to learn more Book a meeting with us during the symposium

We are looking forward to meeting you at the 8th RSC-BMCS / SCI symposium on Ion Channels as Therapeutic Targets. When? March 31th– April 1st, 2025 Where? Hinxton Hall, Wellcome Genome Campus, Cambridge Visit the conference website to learn more Book a meeting with us during the event

We’re excited to be attending the 23rd annual French Membrane Group Conference (GEM 2025), a renowned international event exploring the vital role of cellular membranes in biology, biophysics, and beyond.When? April 1–4, 2025Where? Nausicaà, Boulogne-sur-Mer, FranceVisit the conference website to learn moreBook a meeting

We’re delighted to participate at the 1st edition of the Bioelectricity Cluster 2025, an exciting forum dedicated to advancing research in bioelectricity and electrophysiology across diverse biological systems. When? April 8-11, 2025 Where? University of Oxford, Oxford, UK Visit the conference website to learn more

Phentolamine, a non-selective α-adrenoreceptor antagonist, is widely used in clinical settings to reverse local anaesthesia by promoting vasodilation and drug clearance. While generally well tolerated, it has been associated with adverse effects such as tachycardia and, paradoxically, pain relief in some cases. Previous studies have suggested that phentolamine may interact with molecular targets involved in […]

We are glad to be part of SOT 2025. This event is an ecosystem of events and channels that enable the biologics drug discovery & development community to come together. 📍 Find us at Booth #732 – We are joining our partners from innoVitro to showcase our Cell Analytics platofrms. Join us to discuss your […]

We’re excited to be part of NextGen Biomed 2025, where innovators in biologics drug discovery & development come together. Join us to explore the latest advancements in live-cell analytics with AtlaZ, now enhanced with GxP compliance for regulated environments. 📍 Find us at Booth #60 – See our AtlaZ in action, discuss your research with […]

🎗 Cancer affects us all. Most of us know someone who is fighting this battle. With around 20 million new cancer cases diagnosed each year, it’s something that touches almost every family, every group of friends, every workplace. There’s a lot of incredible work happening in research and medicine to better understand cancer and find […]

Biological nanopores are powerful tools for single-molecule analysis. However, existing nanopore technologies often struggle to accurately analyze large, folded proteins due to limitations in pore size and stability. A recent study introduces a novel biological nanopore system based on complement component 9 (C9), a protein that plays a key role in the immune system’s membrane […]

KCNQ2 variants are a significant cause of early-onset epilepsy in children, with a wide spectrum of clinical presentations and outcomes. These variants can lead to diverse phenotypes, ranging from self-limited familial neonatal epilepsy (SLFNE), characterized by good developmental outcomes, to severe developmental and epileptic encephalopathies (DEEs) associated with profound global disability. Recent research has focused […]

While SCN2A variants are known to cause a spectrum of neurodevelopmental disorders, it looks like the full extent of SCN2A-related conditions remains to be fully clarified. A recent study has uncovered a significant association between rare SCN2A variants and malformation of cortical development (MCD) in patients with developmental and epileptic encephalopathy (DEE). The researchers identified […]

Scientists from Sanofi and Axxam have developed two novel high-throughput screening (HTS) assays for GLUT9/SLC2A9, a crucial urate transporter, advancing the field of drug discovery for hyperuricemia and gout treatment. GLUT9 plays a vital role in urate homeostasis, being the sole transporter of reabsorbed urate from renal epithelial cells to blood. Elevated serum urate levels […]

In his third preclinical ion channel drug discovery blog, Marc Rogers explores the evolution of antibodies as ion channel modulators, highlighting breakthroughs in monoclonal antibodies, nanobodies, and antibody-toxin chimeras across immunology, cardiology, neuroscience, and oncology. Key case studies include Kv, Nav, Cav, TRP channels, and GPCR targets revealed through manual and automated patch clamp technologies​.

February is Biophysical Society month, and we’re excited to connect with you at the 69th Biophysical Society Annual Meeting in Los Angeles! 📍 Find us at Booth #509 – See our instruments in action, discuss your research with our experts, or simply stop by for a friendly chat. We look forward to engaging conversations on […]

At Nanion Technologies, the holiday season is a time to reflect, express gratitude, and give back. For several years, we’ve chosen to focus on making a positive impact on our natural and social environments by supporting non-profit organizations. Our hope is that these actions inspire others to reflect on their blessings and support local communities, […]

Available on-demand. Watch now! Do you have any questions about the webinar? Feel free to reach out to us! ] Contact us [ Explore related tools and resources:   The PrecisION™ hnAChR α7/ric3 cell line offers reliable electrophysiological measurements of nAChR α7/ric3 activity.  ] Learn more [ Our NPC-384 chips for SyncroPatch 384 enable high-throughput studies of ion channels, including fast ligand-gated and […]

Glioblastoma (GBM) remains one of the deadliest brain cancers, with limited advancements in treatments over the past 30 years. Current therapies have not significantly improved survival rates, necessitating new therapeutic strategies. In this regard, ion channels, increasingly implicated in tumorigenesis, represent a potential target for drug repurposing due to the availability of numerous approved ion […]

Artificial cells, often created by encapsulating protein expression systems in lipid vesicles, have shown great potential for mimicking living cell processes. However, for these cells to communicate with their environment, protein translocation across lipid membranes must take place. In natural cells, this process is carried out by complex systems that are difficult to reproduce in […]

Post-acute sequelae of COVID-19 (PASC) affects an estimated 65 million people globally, with many experiencing cardiovascular symptoms (CVS) that persist long after the initial infection. The cause of PASC-CVS remains elusive, but growing evidence suggests a link to chronic inflammation. A recent study investigated the role of chronic inflammation in PASC-CVS and its potential impact […]

Although originally designed for drug discovery, high-throughput automated patch clamp (APC) systems are increasingly used in academia, particularly for studying ion channel variants. Nevertheless, many academic researchers still think these systems are overkill for their needs – especially when facing limited cell availability or tight budgets. So, does this mean that academic labs should miss […]

The mitochondrial ADP/ATP carrier is essential for cellular energy production by exchanging ADP and ATP across the mitochondrial inner membrane. However, a fundamental question has long puzzled researchers: How does this carrier import negatively charged ADP against a strong membrane potential while exporting ATP? Mitochondria maintain a membrane potential of about 180 mV, which is […]

In our previous post, we discussed ion channels and transporters, exploring their differences in speed, energy requirements, and structure. But ion channels and transporters, though distinct, often work together in remarkable ways that go beyond their individual roles. Moreover, some transporters exhibit hybrid transporter-channel characteristics, blurring the line between channels and transporters. For example, in […]

Clay Armstrong once said, “…ion channels are the most important single class of proteins that exist in the human body…” To him, they were the key players – without them, our nerves couldn’t fire, our muscles wouldn’t contract, and our brains wouldn’t think. Ron Kaback, however, had a different take. “Ion channels? Just boring holes […]

When: 05.12. – 06.12.2024 Venue: Omni Los Angeles Hotel at California Plaza. 251 South Olive Street, Los Angeles, California, USA Go to the Conference website here   Meet the Nanion team Join us for the 2024 International Scientific Symposium and Family Conference, hosted by SLC6A1 Connect. This groundbreaking two-day event will bring together leading researchers, clinicians, […]

When: 16.11. – 18.11.2024 Venue:  Chicago, IL McCormick Place Convention Center Go to the Conference website here     Meet the Nanion Team Join us at the AHA scientific sessions 2024 to connect with Ronald Knox (Senior Business Executive) and Sonia Marsilio (Inside Sales) at booth #2020 to learn more about our Cells Analytics platforms that offer fast, […]

When: November 12-14, 2024 Venue: Institute of Physiology, Lecture hall Robert-Koch-Str. 27 (Innenhof), 48149 Münster Host: Dr. Christoph Brenker   Hands-on Workshop: Smart Tools for Studying Membrane Transport – Accelerating Academic and Industrial Ion Channel and Transporter Research Join us at the University of Muenster for an exciting hands-on workshop presented by Nanion Technologies. Markus […]

When: 02.12. – 03.12.2024 Venue: Hotel Le Saint Paul, 29 Bd Franck Pilatte, 06300 Nice Go to the Conference website here   About the meeting The SFET Meeting on Toxinology is back for its 30th edition, bringing together researchers and experts from around the globe to explore the dual nature of toxins—agents of harm and tools of […]

When: 06.11. – 08.11.2024 Venue: Novotel London West. 1 Shortlands, Hammersmith International Ctre,London, W6 8DR Go to the Conference website here.   Meet the Nanion Team Join Elena Dragicevic (Global Marketing Manager) and Giovanna De Filippi (Business Development Manager) at booth #11 to learn more about our Cells Analytics platforms that offer fast, label-free, and real-time cellular […]

When: 20.11.2024 Venue: Starling Hotel – EPFL, Salle de Réunion. Route Cantonale 31. 1025 Saint-Sulpice Visit the conference page here   Join us at the LS2 ICMT & Biophysics Joint Meeting 2024 Our representative Fitzwilliam Seibertz, Scientific Sales, will deliver a talk entitled “Novel High Throughput Technologies in Drug Development,” focusing on the pioneering methods that […]

The SLC17 family of transporters plays crucial roles in the body. Some members, such as VGLUTs, help accumulate neurotransmitters in secretory vesicles. Others, like Sialin, remove carboxylated monosaccharides from lysosomes, while some assist the kidneys and liver in eliminating organic anions. Despite decades of research, the mechanisms underlying SLC17 organic anion transport remain poorly understood. […]

The 70 kDa Heat Shock Protein (Hsp70) chaperones are critical components of the cell’s protein quality control system, playing key roles in protein folding, translocation, and disaggregation. Proteins synthesized in the cytoplasm rely on Hsp70 chaperones to move through specialized membrane channels/pores into organelles. Despite their well-established functions, the exact physical mechanism by which Hsp70 […]

LYCHOS (LYsosomal CHOlesterol Signalling) is an important human protein located in the lysosomal membrane and acting as a cholesterol sensor. LYCHOS transduces cholesterol levels into activation of mTORC1 signalling, thereby regulating cellular metabolism and growth. Despite its significance, the structural basis of how LYCHOS assembles and operates has remained elusive. In a recent study published […]

Why are some antibiotics more effectively absorbed in the body than others, even within the same class? Beta-lactam antibiotics, such as penicillins and cephalosporins, are among the most widely used drugs to combat bacterial infections. However, their effectiveness depends not only on their ability to kill bacteria but also on how well they are absorbed […]

When: 29.10. – 01.11.2024 Venue: NIH campus. Bethesda, Maryland Go to the Conference website here   Meet the Nanion Team Join us at our upcoming event to connect with Rocco Zerlotti (Application Scientist), Cecilia George (HQ Senior Sales Manager SURFE2R / Senior Scientist), and Federico Amodeo (Field Application Scientist). Discover how Nanion’s versatile solutions can elevate […]

When: 29.10. – 31.10.2024 Venue: Sede Antonio Machado de Baeza Visit the conference page here   Join us at the cellular sensors workshop Our representative Giustina Rotordam, Senior Application Scientist, will deliver a talk and present a poster on groundbreaking developments in cellular sensor technologies. This is a fantastic opportunity to connect with Giustina and […]

When: 31.10. – 01.11.2024 Venue: Garvan Auditorium, Garvan Institute of Medical Research, 384 Liverpool Street, Darlinghurst. Visit the conference page here     About the Symposium We are proud to sponsor the Sydney Cardiovascular Symposium 2024. The Sydney Cardiovascular Symposium is Australia’s premier cardiovascular research event, and this year’s theme, “From Molecules to Therapies for Cardiovascular […]

The voltage-gated sodium channel Nav1.7 plays a critical role in transmitting pain signals in nociceptive neurons. Genetic mutations in Nav1.7 can lead to various pain disorders, including extreme pain conditions and congenital insensitivity to pain. Despite its importance, targeting Nav1.7 for pain treatment has proven difficult due to its structural similarity with other sodium channel […]

The ryanodine receptor 1 (RyR1) is a critical calcium release channel in skeletal muscle cells, essential for muscle contraction. Malfunction or dysregulation of RyR1 can lead to severe muscle disorders, including malignant hyperthermia (MH) – a life-threatening reaction to certain volatile anesthetics, which presumably bind and bias RyR1 to an open state, causing uncontrolled calcium […]

Ion gradients are crucial for maintaining cellular processes, fueling essential functions such as nutrient transport, metabolism, and energy production. Synthetic or artificial cells, like their biological counterparts, also require a sustainable energy source to drive these functions. However, previous attempts to power synthetic cells have struggled to maintain long-term energy production. In a recent study […]

Pufferfish poisoning poses a serious threat to human health, with numerous incidents reported worldwide. The toxicity of pufferfish is primarily attributed to tetrodotoxins (TTXs) and paralytic shellfish toxins (PSTs), both of which are potent blockers of voltage-gated sodium channels. However, the toxicity profiles of individual TTX analogues and the presence of PSTs in certain pufferfish […]

When: 04.09. – 08.09.2024 Venue: Woods Hole, Massachusetts (USA) Go to the Conference website here Meet us at the SGP 2024   Join George Okeyo (Business Development and Strategy) and Federico Amodeo (Field Application Scientist) to learn about our advanced automated devices for researching ion channels, membrane transporters, pores and nanopores, cardiomyocytes, and various other cell […]

When: 08.09.- 11.09.2024 Venue: Sete, France Go to the Conference website here   Meet us at the 33rd Ion Channels & Channelopathy Meeting   Join Artem Kondratskyi (Scientific Solutions Manager) to discover how Nanion’s versatile solutions can enhance your research on ion channels and channelopathies. Discover how our innovative solutions provide a wide range of throughput […]

When: 22.10. – 23.10.2024 Venue: Nanion Technologies Headquarters. Munich, Germany Join us at the Nanion User Meeting 2023   Over the years, Nanion has grown and built a community constituted by our customers and collaborators that join us every year at the Nanion User Meeting (NUM) to discuss the latest updates in of drug discovery, […]

When: 15.10. – 17.10.2024 Venue: Basel, Switzerland Go to the Conference website here Visit us at booth #239! Advancing cellular research with the AtlaZ   Join us at the Nanion booth to meet our dynamic team and explore the latest advancements for cellular research. Our experts, including Elena Dragicevic (Global Marketing Manager), Giovanna De Filippi (Business […]

When: 02.10. – 04.10.2024 Venue: Evotec Campus Levi-Montalcini, Verona, Italy Go to the Conference website here   Advancing GPCR Research with the AtlaZ   Join us at the Nanion booth to meet our dynamic team and explore the latest advancements for cellular research. Our expert, Giovanna De Filippi (Business Development Manager) will be on hand to […]

When: September 19th, 2024 from 16:00 – 17:00 h CEST Venue: via Zoom   Summary of the webinar Explore advanced electrophysiological techniques in red blood cells. This webinar covers automated patch clamp for ion channel study, highlighting the roles of Piezo1, KCa3.1, and TRPV2 in RBC functions and diseases, and the concept of Pseudo Action […]

When: 05.10. –  09.10.2024 Venue:  McCormick Place Convention Center in Chicago Go to the Conference website here Join Nanion Technologies at SfN 2024 in Chicago! We are excited to participate in the Society for Neuroscience (SfN) 2024 Annual Meeting in Chicago, bringing you cutting-edge advancements in neuroscience research. Discover how we continue to push the boundaries in ion […]

When: 19.09. – 21.09.2024 Venue: Campus of the University of Vienna. Auditorium Centre. Spitalgasse 2, Hof 2. 1090 Vienna, Austria Go to the conference website here Meet us at the DPG meeting 2024   Join Fitzwilliam Seibertz (Scientific Sales) and Kefan Yang (Application Scientist) to explore our cutting-edge automated devices for researching ion channels, membrane […]

When: 22.09. – 25.09.2024 Venue: Town and Country Resort, San Diego, CA Go to the Conference website here Meet us at the SPS 2024 Visit us at booth #401 to meet our team and explore our cutting-edge automated devices designed for researching ion channels, membrane transporters, cardiomyocytes, and other cell types. Our experts, Sonja Stoelzle-Feix (Director […]

When: 22.09. – 25.09.2024 Venue: Leipzig University. Campus Augustusplatz. 04103 Leipzig, Germany Go to the conference website here Meet us at the DGfB meeting 2024   Join Conrad Weichbrodt (Senior scientist/Product Manager of Orbit systems) to learn about our advanced automated devices for the electrophysiological research of ion channels, porins, and other pore-forming species including toxins […]

Current treatments for pain and inflammation, such as opioids and NSAIDs, are associated with dependency and adverse side effects. The opioid crisis, characterized by the misuse of opioids, particularly synthetic variants like fentanyl and tramadol, has led to a significant number of deaths, underscoring the urgency to develop alternative pain management strategies. Similarly, the long-term […]

The field of synthetic membrane nanopores has long sought to replicate the sophisticated functions of biological ion channels and pores. However, researchers have faced significant challenges in creating stable, large-lumen nanopores with tunable properties. Traditional synthetic nanopores, despite their applications in biosensing, sequencing, and synthetic cells, suffer from limitations such as fixed pore sizes and […]

In his second preclinical ion channel drug discovery blog, Marc Rogers gives a comprehensive review of how the explosion in patient genetic screening and need to profile the thousands of novel channelopathy mutations is being met by the ability of high throughput automated patch clamp to rapidly characterise their biophysical and pharmacological properties, and thereby […]

In order to improve service and technical support for customers in Australia, Nanion has entered a strategic alliance with BioTools. BioTools will carry out all installations, service visits and planned maintenance visits for Nanion’s instruments in all eastern states of Australia, thus minimizing response time and downtime for our Australian customers in the east states. […]

Giant unilamellar vesicles (GUVs) serve as model systems for studying membrane behavior, offering insights into processes such as membrane deformation, cargo transport, and vesicle fusion. However, achieving precise control over these processes in synthetic systems remains challenging. The ability to programmatically remodel lipid membranes and GUVs in a controlled and reversible manner is a significant […]

The immune system has been identified to play a significant role in the development and maintenance of many cardiac disorders. Autoantibodies against specific cardiac ion channels have been detected in plasma from patients with arrhythmic disorders such as atrial fibrillation. It is thought that this novel mechanism may impart drastic changes on ion channel function, […]

Brugada syndrome (BrS) is an autosomal dominant cardiac disorder. It is commonly associated with loss of function mutations in the SCN5A gene, encoding the cardiac voltage gated sodium channel. BrS-associated SCN5A variants can therefore lead to reduced cardiac excitability and conduction velocity, often resulting in patients experiencing abnormal cardiac rhythms, ventricular arrhythmias and sudden cardiac […]

Understanding the relationship between cellular senescence and cancer is crucial in developing innovative treatments for age-related diseases and cancer. Ageing, cellular growth and cancer development appear to be different processes, but they may have common origins. Cellular senescence is a state of permanent cell cycle arrest accompanied by a senescence-associated secretory phenotype (SASP), macromolecular damage, […]

Inherited long QT syndrome (LQTS) is an autosomal dominant cardiac disorder that can lead to arrhythmias and sudden cardiac death. It is associated with mutations in several genes, including KCNH2, which encodes the KV11.1 potassium channel crucial for cardiac repolarization. Diagnosing LQTS is challenging due to its highly variable presentation, incomplete penetrance, and dynamic changes […]

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia, affecting millions and increasing the risk of heart failure, stroke, and death. Genetic studies have identified various loci and rare variants associated with AF, particularly in cardiac ion channels and myocardial structural proteins like myosin heavy chain 6, myosin light chain 4, and titin. […]

Solid-supported membrane-based electrophysiology (SSME) has evolved into an accessible and convenient technology for measuring electrogenic membrane transport, offering advantages in reproducibility, time resolution, and quantitative analysis. This technique relies on capacitive coupling between membrane fragments or reconstituted proteoliposomes and the solid-supported membrane (SSM). Due to their capacitive, transient nature, the electrical signals recorded with SSME […]

Translating drug efficacy and safety findings from healthy to diseased states remains a significant challenge in drug development. Traditional animal models or healthy human cells often fall short in accurately predicting clinical outcomes, necessitating the development of patient-centric models. The advent of induced pluripotent stem cell (iPSC) technology has revolutionized this field, offering a means […]

Transport proteins from the small multidrug resistance (SMR) family play a crucial role in protecting bacteria from a wide range of quaternary ammonium antiseptics (QACs), which are commonly used in antibacterial hand soaps and cleaning solutions. However, the exact molecular mechanisms behind their ability to transport such a diverse array of substances have been unclear. […]

Peptidomimetics, synthetic molecules designed to mimic the structure and function of peptides, offer promising avenues for therapeutic applications. These molecules can be engineered to interact with biological systems in specific ways, such as targeting DNA structures or forming transmembrane channels. One area of particular interest is their potential to treat cancer by stabilizing G-quadruplex (G4) […]

Cardiac toxicity testing is crucial in the drug development process to ensure the safety of new pharmaceutical compounds. The Comprehensive in-vitro Pro-arrhythmia Assay (CiPA) initiative aims to improve the prediction of drug-induced arrhythmias by integrating multiple data sources, including hERG channel assays, to assess the proarrhythmic risk of drugs. Given the risks associated with hERG […]

When: 02.09. – 03.09.2024 Venue: The University of Salford, UK Go to the Conference website here Meet us at the BSCR meeting 2024   Join Fitzwilliam Seibertz (Scientific Sales) to learn about our advanced automated devices for researching cardiac ion channels, cardiac safety, drug discovery, cardiomyocytes, and various other cell types. Discover how our innovative solutions […]

When: 07.07. – 12.07.2024 Venue: Mount Holyoke College. 50 College Street, South Hadley. Massachusetts, United States Go to the Conference website here   Meet us at the GRC on Ion Channels Connect with Dr. Tom Goetze (Senior Scientist) to learn about our platforms with different throughput for investigating ion channels. Tom will present the poster “Mechanical activation of […]

When: 29.07. – 31.07.2024 Venue: Carl Friedrich von Siemens Stiftung, Südliches Schlossrondell 23, 80638 München, Germany Go to the Conference website here   Meet the Nanion Team Connect with Dr. Markus Rapedius, our Senior Scientist and Product Manager for Chips (APC), to explore the versatile solutions Nanion offers for your research needs. Whether you’re investigating channelopathies, […]

When: 22.07. – 25.07.2024 Venue: Hilton Chicago | Chicago, Illinois Go to the Conference website here   Meet us at the BCS 2024 Join Wyatt Hall (Director of Sales, Nanion Inc), and Ronald Knox (Senior Business Executive) to learn more about our automated devices to research Ion Channels, Membrane Transporters, Pores and Nanopores, Cardiomyocytes and […]

Atrial fibrillation (AF) is a common cardiac arrhythmia associated with high mortality and morbidity. Even though we’ve made progress in understanding the molecular mechanisms behind AF, treating it remains challenging. A recent study presented new data showing that targeting intracellular calcium buffering mechanisms might be a promising way to manage AF. It has been known […]

Webinar now available on-demand!     Summary of the Webinar   G-protein coupled receptors (GPCRs) are among the most heavily addressed drug targets in medicinal chemistry and pharmacology. It has been estimated that about 40% of all prescription pharmaceuticals on the market address GPCRs in different target tissues. So far the screening for new agonists […]

When: 27.06.2024, 16:00 – 17:00 h CEST (8:00 – 9:00 h MDT) Venue: online Summary of the Webinar   Globally, over 65 million individuals are estimated to suffer from post-acute sequelae of COVID-19 (PASC). A large number of individuals living with PASC experience cardiovascular symptoms (i.e. chest pain and heart palpitations) (PASC-CVS). The role of […]

Immuno-oncology represents a groundbreaking shift in cancer treatment by harnessing the body’s own immune system to fight cancer. Unlike traditional therapies such as chemotherapy and radiation, which can damage healthy cells, immuno-oncology aims to enhance the immune system’s natural ability to detect and destroy cancer cells, offering a more targeted and potentially less toxic approach. […]

GABA transporter 1 (GAT1) is a critical component in the central nervous system, responsible for the reuptake of GABA from the synaptic cleft back into presynaptic neurons. By controlling GABA levels, GAT1 influences neuronal excitability and overall network activity, playing a key role in the balance between excitation and inhibition in the brain. Dysfunctions in […]

In their recent book chapter in “Potassium Channels: Methods and Protocols,” Ciria C. Hernandez, Luis E. Gimenez, and Roger D. Cone describe a very interesting application of Automated Patch Clamp (APC) technology to advance the study of GPCR-gated ion channels and accelerate the discovery of biased modulators of GPCRs. GPCRs are critical drug targets due […]

Cell line maintenance and cell preparation for both conventional and high-throughput patch-clamping remain manual tasks and represent the bottleneck for the kinetic screening of ion channels, in particular voltage-gated ion channels (VGICs). In their recent book chapter, Emmanuelle Logette and Rajnish Ranjan address this bottleneck by introducing a new approach that significantly enhances the efficiency […]

Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare, severe epileptic disorder characterized by early onset seizures resistant to standard treatments. EIMFS is associated with mutations in the KCNT1 gene, which encodes the sodium-activated potassium channel SLACK (KNa1.1, Slo2.2). SLACK channels regulate neural excitability, playing a key role in afterhyperpolarization (AHP) following neural […]

Following their discovery of the inner workings of a unique voltage-gated transporter, SLC9C1, in sperm, David Drew’s lab continues to delight us with their remarkable findings. This time, the focus is on the K+ efflux transporter KefC. Potassium homeostasis is crucial for the survival of bacteria as it is involved in fundamental cellular processes, such […]

Myocarditis, a severe condition characterized by heart inflammation and impaired cardiac function, is a common cause of sudden cardiac death and heart transplants among young people. This condition can be triggered by both genetic and environmental factors, including viral infections and reactions to vaccinations. Recently, mutations in the DSP (desmoplakin) gene have been identified as […]

Transporters are vital for numerous cellular functions, from nutrient uptake and waste removal to maintaining ion balance and facilitating signal transduction. They are indispensable for cell survival and overall organismal health and are implicated in numerous diseases. Despite their importance, the functional characterization of transporters has been hampered by technical challenges and high costs associated […]

When: 05.06. – 07.06.2024 Venue: Van Andel Institute 333 Bostwick Ave. NE Grand Rapids Go to the Conference website here   Meet us at the Gateway Ion Channel Symposium   Join Rodolfo Haedo (COO) and Wyatt Hall (Director of Sales) to explore the latest advancements in ion channels and membrane transporters research investigations using our Automated […]

As children, many of us loved reading stories about the adventures of indigenous South American Indians, vividly depicted in novels like James Fenimore Cooper’s The Last of the Mohicans. These stories sparked our imaginations and took us on thrilling journeys through unexplored landscapes. Living in constant warfare with other tribes or colonizers, the South American […]

The global health community is increasingly alarmed by the rise of antibiotic-resistant bacteria. These resilient strains pose significant threats to public health, leading to infections that are difficult to treat with conventional antibiotics. Methicillin-resistant Staphylococcus aureus (MRSA) is a prime example, known for causing severe infections in hospitals and communities alike. The urgent need for […]

What a beautiful day today! The sun is shining, and a nice breeze is blowing in your face. You are peacefully sitting on a bench in the park, reading through the latest news on ion channels and transporters. Everything is great, calm, and quiet. Suddenly, someone from behind runs up to you and loudly shouts, […]

Millions of years ago, certain retroviruses integrated their genetic material into our ancestors’ genomes. Instead of causing harm, these viral genes have been co-opted to perform critical functions in human biology. Two such genes originating from ancient retroviruses now encode for human syncytin-1 and suppressyn proteins, which play crucial roles in cell-cell fusion at the […]

Plants have a remarkable ability to grow/bend toward the light, a phenomenon known as phototropism. This adaptive trait allows plants to maximize their exposure to sunlight, which is essential for their survival and growth through photosynthesis. Interestingly, at the heart of this process are the auxin transporters, which facilitate the movement of the hormone auxin […]

Botulinum toxin type A (BoNT/A), also known as Botox, is widely used in cosmetic dermatology, prized for its ability to temporarily relax facial muscles and give the skin a smoother, more youthful appearance. But beyond its use in cosmetics, BoNT/A also treats various medical conditions including chronic migraines, cervical dystonia, strabismus, hyperhidrosis, and neuropathic pain. […]

Hello to all ion channel aficionados, Star Wars enthusiasts and space explorers. It’s May 4th – the long-awaited Star Wars Day. And before you dive into rewatching your favorite moments of this iconic saga, let us ask you a question: Do you think the incredible powers of Jedi in Star Wars are purely science fiction, […]

The potential of immunotherapy has sparked immense interest and investment in research, as it holds the promise of more effective and personalized cancer therapies. But what differentiates this type of therapy from others? Immunotherapy enhances or modifies the immune system’s natural ability to identify and eliminate cancer cells. Unlike traditional treatments like chemotherapy and radiation, […]

Available on-demand. Watch now!   When: 23.05.2024, 16:00 – 17:00 h CEST (8:00 – 9:00 h MDT) Venue: via Zoom

When: 05.06. – 07.06.2024 Venue: The Centro Kursaal – Kursaal Elkargunea, S.A. Zurriola Hiribidea, 1, 20002 Donostia – San Sebastián. Go to the Conference website here   Meet us at the ESAB 2024 Join Conrad Weichbrodt (Product Manager of the Orbit family) at booth #TBD to explore the latest advancements for investigations using artificial lipid bilayers. […]

When: 23.06. – 26.06.2024 Venue: Renaissance Tuscany Il Ciocco. Via Giovanni Pascoli. Lucca (Barga), Italy Go to the Conference website here   Meet us at the GRC on Calcium Signaling Connect with Dr. Fitzwilliam Seibertz (Scientific Sales) to learn about our platforms with different throughput for investigating ion channels and transporters. Fitzwilliam will have a talk. Stay tuned […]

When: 07.06. – 08.06.2024 Venue: Friends House. 173-177 Euston Road, London. NW1 2BJ Go to the Conference website here   Advancing Membrane Transporters Research   Connect with Giovanna De Filippi (Business Development Manager) to learn about our SSM-based Electrophysiology platforms can help you boost your CLC channels transporters´ research. We are proud sponsors of the poster […]

When: 16.06. – 20.06.2024 Venue: Loews Ventana Canyon Resort. 7000 North Resort Drive. Tucson, AZ 85750. USA Go to the Conference website here   Accelerating Cancer Research Connect with the Ronald Knox (Senior Business Executive) and Wyatt Hall (Director of Sales) to learn about our AtlaZ, ideal for cancer research. With our range of throughput capabilities, […]

When: 14.05. – 18.05.2024 Venue: Mingde Conference Hall. N° 9 WuTongYu Academic Exchange Center, Huazhong Univ. of Sci. & Tech., No.1037 Luoyu Rd., Wuhan, China Go to the Conference website here Meet us at the Symposium Join the Nanion Chinese team at the 13th Chinese symposium on calcium signaling. Nanion combines trusted scientific support with exceptional […]

When: 23.06. – 26.06.2024 Venue: Megaron Athens International Conference Centre (MAICC) Go to the Conference website here   Advancing in Drug Discovery Connect with Dr. Fitzwilliam Seibertz (Scientific Sales) at EPHAR 2024  to learn about our platforms with different throughput for investigating ion channels and transporters.   Meet us at the poster session Dr. Fitzwilliam Seibert will […]

When: 25.06. – 29.06.2024 Venue: Messe Wien Exhibition & Congress Center. Go to the Conference website here   Advancing Neuroscience Research Connect with Elena Dragicevic (Global Marketing Manager) and Ali Obergrussberger (Scientific Communications Manager) to learn about our Automated patch clamp and Membrane biophysics platforms can help you advance your neuroscience research.   Meet us at […]

When: 21.05. – 24.05.2024 Venue: Université de Montréal, in Montreal (QC) Canada. Go to the Conference website here. Meet our Bilayer Experts Join us at the Nanion booth to meet our dynamic team for live experiments. Our experts George Okeyo (Business Development and Strategy) and Federico Amodeo (Field Application Scientist) will be on hand to discuss […]

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are an effective tool for drug screening and modeling patient-specific diseases in a laboratory setting. They offer a sustainable alternative to primary human cardiomyocytes, bypassing the ethical and supply issues associated with these cells. However, a major limitation is that hiPSC-CMs often exhibit immature characteristics that resemble fetal […]

May 1st might be widely recognized as International Workers’ Day, but there’s another, perhaps more colorful, side to this date. Known also as May Day, it carries deep historical and cultural connections to flowers and the joys of spring. In many European places, people really get into the spirit of spring on this day. They […]

Do you like pretzels? We sure do. Nanion is a German company, and our headquarters is in Munich, where pretzels are more than just a snack. So yes, we do love pretzels, and since today is Pretzel Day, we thought we’d tell you a story about this tasty and twisty treat. Have you ever wondered […]

Pluripotent stem cells can differentiate into various cell types under the influence of signaling pathways such as BMP4, Nodal, and Wnt/β-catenin. These pathways can be pharmacologically modulated to achieve in vitro differentiation into specific cell types. However, variations in cell line responses and the complexity of signaling interactions pose challenges in achieving consistent and efficient […]

In his pre-clinical drug discovery blog, Marc Rogers provides expert insights on how CBD, found in marijuana, may affect ion channels, explaining its therapeutic potential, as highlighted in recent literature and drug discovery efforts.   After academic research as a neuroscientist and 20 years of commercial ion channel drug discovery, Marc Rogers now works as […]

Humans have an intriguing penchant for consuming what nature intended as deterrents. Chili peppers, horseradish, some toxic mushrooms, and that wild fugu fish… people just love all these. And it’s kind of funny because nature made these things hot or dangerous to keep animals away, but here we are, not just eating but actually enjoying […]

The presence of marine toxins in our oceans and seas is escalating, posing significant risks to public health. These toxins accumulate in seafood and can cause severe intoxications if consumed. Among these, tetrodotoxin (TTX) is particularly notorious. Found in pufferfish and certain shellfish, TTX is highly potent and responsible for numerous poisoning incidents globally. Traditional […]

Chronic Myeloid Leukemia (CML) is a type of cancer that affects the blood and bone marrow and is commonly treated with drugs known as BCR-ABL1 tyrosine kinase inhibitors (TKIs). Nilotinib, one such TKI, is recognized for its effectiveness against CML, but it is also associated with a concerning side effect: 23.5% of patients taking nilotinib […]

Paracetamol (also known as acetaminophen) is a familiar over-the-counter medication widely used for relieving pain and reducing fever. Interestingly, despite its widespread use, its exact mode of action is still not fully understood. Traditionally, it was believed that paracetamol’s primary mechanism of action involved inhibiting the enzyme cyclooxygenase (COX), which is also targeted by nonsteroidal […]

Cancer continues to be a major challenge in healthcare. Its complex nature, coupled with the ability of various cancer types to resist existing treatments, has led to a relentless search for new anticancer drugs, with researchers looking everywhere, including nature, for potential solutions. A recent study has introduced new data to this search, highlighting the […]

🎙️ On this episode of the Nanion Podcast, we had the pleasure of speaking with Prof. Yamuna Krishnan, a world-leading expert in bionanotechnology, working at the interface of chemistry and cell biology. Together with Yamuna, we dive deep into the heart of cellular function, exploring how the chemistry within cell organelles is reshaping our understanding […]

At the beginning of each month, we get the chance to enjoy another seminar from the SGP EpIC Seminar Series. It’s a fantastic series organized by Jelena Baranovic, Osama Haraz, Conor McClenaghan, Lejla Zubcevic, and Gregory Malar, featuring great speakers and engaging, informative talks. Highly recommended for anyone interested in electrophysiology and ion channels. This […]

Acid-sensing ion channels (ASICs) are proton-gated sodium channels widely expressed in various tissues, including the central and peripheral nervous systems. ASICs play crucial roles in numerous physiological processes, such as pain sensation, fear conditioning, synaptic plasticity, learning, and memory. Additionally, they have been implicated in several pathological conditions, including neurodegeneration (e.g., Parkinson’s, Alzheimer’s) and ischemic […]

Easter is coming! Across the globe, many people are gearing up to celebrate this cherished holiday. It’s a time for families to gather, enjoy festive meals, and participate in joint activities. One of the most beloved Easter traditions, especially for children, is the Easter Egg Hunt. But beyond this, a few other activities are quite […]

Drosophila melanogaster continues to be a goldmine of discovery. In a recent study, researchers at EPFL have unveiled how a family of stress-induced proteins, known as the Turandots, protect the Drosophila respiratory system from its own immune self-attack, specifically against its own antimicrobial peptides (AMPs). AMPs are small, cationic, and typically amphipathic peptides that play […]

Yesterday, in honor of Multiple Sclerosis Awareness Month, we wrote a blog article about Multiple Sclerosis (MS) and ion channels (see here: Multiple sclerosis and ion channels). Today, we’d like to spotlight a recent study on the discovery of new compounds with the potential to become novel remyelinating therapeutics for MS. As we discussed in […]

When: 08.05.2024 Venue:  The Discovery Centre, AstraZeneca, 1 Francis Crick Avenue, Cambridge CB2 0AA. Go to the Conference website here     Meet the Nanion team Join our representatives Niels Fertig (CEO), Ali Obergrussberger (Scientific Communications Manager), and Giovanna De Filippi (Business Development Manager) at the poster session between 14:45 – 15:30h and be part […]

When: 25.04. – 26.04.2024 Venue: 1 Shortlands, Hammersmith International Centre. London, UK. Go to the Conference website here Visit us at booth #15! Advancing Immuno-Oncology Research with the AtlaZ   Join us at the Nanion booth to meet our dynamic team and explore the latest advancements for cellular research. Our experts, including Elena Dragicevic (Global Marketing […]

When: 19.04. – 23.04.2024 Venue: Fletcher Hotel-Restaurant Noordsee-Ameland. Strandweg 42, 9163 GN Nes, The Netherlands. Go to the Conference website here The Nanion team will be present with a talk Join us for an insightful talk at session 2 “Ion channels of the red blood cell – function and disorders” on the characterization of red blood cells using […]

When: April 5-10th, 2024 Venue: San Diego Convention Center. San Diego, California Go to the Conference website here   Meet the Nanion Team Join Wyatt Hall (Director of Sales, Nanion Inc), and Ronald Knox (Senior Business Executive) to learn more about our newest impedance system, AtlaZ. The AtlaZ enables label-free, continuous, real-time monitoring of cancer immune […]

Multiple Sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. In MS, the immune system mistakenly attacks and damages the myelin, which enwraps neuronal axons and is crucial for the saltatory propagation of electrical impulses along nerve fibers. This disrupts communication between the brain and the rest of the body, leading […]

Today is World Water Day, and considering that about 60% of our body is pure water, we couldn’t pass up the opportunity to talk a bit about water (and channels, of course) on this special day. Water is indispensable to life as we know it. Beyond being the unsung hero in our morning coffee or […]

Candida albicans is a fungus that is a common member of the human body’s microbiota. In healthy individuals, it resides on the skin and inside the mouth, throat, gut, and genital areas, where it forms part of the normal microbial community. However, under certain conditions, such as a weakened immune system or disturbances in the […]

Yesterday, on Global Recycling Day, was a good moment to reflect more on protecting our environment and embracing the 3Rs: Reduce, Reuse, Recycle. And when we think about reusing and recycling in the cellular context, what first comes to mind? Of course, it’s autophagy, a cellular process in which the cell degrades and recycles its […]

Today is World Sleep Day, and we thought it’s the perfect occasion to explore some intriguing facts related to sleep and ion channels, especially through the lens of Christopher Nolan’s masterpiece movie “Inception.” In “Inception,” Dom Cobb (Leonardo DiCaprio’s character) and his team navigate through layers of dreams, engaging in spectacular heists and battles, all […]

In analytical chemistry and biosensing, there’s a constant search for better ways to quickly and accurately analyze complex biological samples. Traditional techniques, such as High-Performance Liquid Chromatography (HPLC), spectrophotometry, and mass spectrometry, have been the cornerstone of analytical practices for decades. However, these methods often fall short in the direct and rapid analysis of complex […]

Metformin is the main first-line treatment for type II diabetes, prescribed to millions of people worldwide. But have you ever wondered what happens after it’s done its job in patients? Surprisingly, metformin and its metabolites, including guanylurea, are among the most prevalent anthropogenic chemical pollutants in wastewater globally, reaching microM concentrations. These compounds are not […]

The Membrane Physiology Symposium hosted by Nanion Technologies will take place in Napa Valley California at the Meritage Resort & Spa. This event will include a diverse range of research covered by established leaders in their fields, collaborative interactions, multiple networking sessions, a variety of great sponsors, great food, and Napa Valley’s famous wines.

Horses have played a crucial role in human history, impacting various areas of our lives. Before the advent of modern vehicles, horses were the primary means of transportation for people and goods. They were also vital for delivering messages and significantly contributed to farming by enabling more efficient cultivation of land. Horses have been integral […]

Plant propagation stands as a cornerstone practice in agriculture, essential for cultivating the diversity of crops. This age-old practice involves creating new plants from existing specimens, ensuring the continuation and multiplication of species and varieties. Propagation techniques span from the simple sowing of seeds to sophisticated methods like grafting, stem cuttings, and tissue culture. Each […]

February 24 is SCN2A Awareness Day, and it’s a prime opportunity to spotlight the SCN2A gene, infamous for its association with a spectrum of neurodevelopmental disorders, such as epilepsy and autism. SCN2A encodes the neuronal voltage-gated sodium channel (VGSC) NaV1.2, which is widely expressed throughout the central nervous system but not in peripheral tissues. More […]

Today, we’re celebrating a giant of science – Alessandro Volta. His legacy is something we engage with daily, albeit often unconsciously. Every time we discuss voltage-gated ion channels, use a voltage clamp, or analyze volt-ampere curves, we’re walking in the footsteps of Volta. The very term “volt,” as fundamental to the field of electrophysiology as […]

Nowadays, it seems like many people are on a mission to look picture-perfect, influenced by the glossy ideals of beauty shown everywhere in modern society. Magazines and social media platforms actively endorse various procedures to attain and sustain the elusive notion of perfection. Non-surgical procedures such as Botox injections have garnered attention for their ability […]

Left ventricular noncompaction cardiomyopathy (LVNC) poses significant challenges in clinical management due to its association with arrhythmias and heart failure. The underlying molecular mechanisms of ventricular arrhythmias in LVNC patients remain elusive, and there is no special treatment for LVNC. Some previous studies have pointed out that mutations or abnormalities in the SCN5A gene (encoding […]

In a recent BioTechniques interview, Bettina Lickiss (innoVitro) shared her experience of using the AtlaZ platform.

One of the most fascinating aspects of human physiology is the ability of our hearts to beat autonomously, without any external stimuli. At the core of this process is the heart’s natural pacemaker, the sinoatrial (SA) node, which has the ability to generate electrical impulses autonomously, thanks to the special properties of its pacemaker cells. […]

For decades, the addition of fluoride to internal solutions in patch clamp assays, both manual and automated, has been a standard practice to enhance seal resistance and extend the duration of recordings. In manual patch clamping, fluoride has been routinely used when studying voltage-gated sodium (NaV) channels, ensuring high seal resistance, crucial for accurate voltage […]

When we think of animals that can withstand a battle against venomous snakes, our minds might not immediately picture the small, spiny hedgehog. Known for their adorable appearance and quirky charm, hedgehogs are rarely, if ever, considered as the superheroes of the animal kingdom (except maybe the brave blue speedster, Sonic the Hedgehog, from the […]

Cardiac safety testing is a pivotal aspect of drug development, ensuring that new therapeutics don’t inadvertently harm the heart. A key player in this arena is the rapid delayed rectifier potassium current (IKr), mediated by the hERG channel, crucial for cardiac repolarization. Testing drug interference with hERG function is an integral part of the comprehensive […]

National Fun at Work Day is an annual celebration that encourages us to bring a little extra joy into our work lives. It reminds us that the workplace doesn’t have to be all serious and stressful; there’s room for laughter and enjoyment. Our mood and mental health play a significant role in our productivity and […]

Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting over 33 million patients worldwide. It increases the risk of stroke, myocardial infarction, and heart failure, and requires therapy. Despite recent advances, current treatments have variable efficacy, in part because existing AF models do not fully recapitulate the real, AF-susceptible cellular substrate. The main challenge […]

January is Thyroid Awareness Month, a time to highlight the vital role of the thyroid gland in our body’s health. Resembling a butterfly and nestled in the neck, the thyroid is key to regulating our metabolism. It produces hormones like thyroxine (T4) and triiodothyronine (T3), which govern metabolic processes vital to our survival—from regulating heart […]

Voltage-gated sodium channels (NaVs) have consistently been a focal point of scientific interest due to their integral role in neuronal excitability and pain transmission. Among these, NaV1.8 (SCN10A), a channel specifically expressed in peripheral nociceptors, has emerged as a compelling target for novel analgesic development. Gain-of-function mutations in SCN10A are associated with increased pain sensation […]

It’s a chilly day here in Munich, the kind of day that begs for the warm embrace of a steaming cup of tea. Especially since today we celebrate Hot Tea Day. So, let’s wrap our hands around our favorite mugs and explore how certain compounds in tea can influence ion channels in our bodies. Whether […]

Among the earliest branches of the tree of life are two groups of microscopic organisms: Bacteria and Archaea. Initially grouped together as Prokaryotes due to their lack of a defined nucleus, these two groups share some fundamental biochemistry, but differ significantly in several key aspects including cell walls, DNA replication machineries, DNA packing structures, and […]

Today is January 5, and it happens to be National Bird Day. Sounds a bit like Birthday, doesn’t it? And who doesn’t enjoy celebrating birthdays! So, let’s take a few minutes to celebrate our feathered friends (not without tying in ion channels, of course). Birds are actually quite important to us. These living descendants of […]

Proteins play a crucial role in various cellular functions, from providing structural support to catalyzing chemical reactions. Following their synthesis, many proteins undergo a series of biochemical transformations that increase their complexity and functionality. These transformations, known as Post-Translational Modifications (PTMs), are critical for regulating protein activity, structure, localization, and interactions. For instance, phosphorylation can […]

To celebrate Christmas this year, we decided to gift everyone in the world by donating to The Ocean Cleanup. You know how we all love the ocean for its beaches, fresh and salty air, and waves lapping rhythmically against the shore. Rarely, though, do we think that those waves are not just carrying seashells but […]

Over the past decade, optogenetics has emerged as a major driver of progress in the life sciences. This technique, which involves controlling cellular behavior using a combination of genetic engineering and light, has opened new horizons in both research and therapeutic applications. Multiple clinical trials using optogenetic approaches to treat various diseases are currently in […]

Arrhythmogenic cardiomyopathy (ACM) is a complex, genetic cardiac disorder, leading to lethal arrhythmias and sudden cardiac death. The pathophysiology of ACM is closely linked to mutations in desmosomal genes, particularly the PKP2 gene, which encodes for the plakophilin-2 protein, a known desmosome stabilizer. Mutations in the PKP2 gene lead to reduced plakophilin-2 protein levels in […]

Ten years ago, Nanion shipped the SyncroPatch 384PE automated patch clamp instrument to its first ever customer. The launch of the SyncroPatch 384PE was preceded by an intense period of innovation and development from scientists and engineers at Nanion, working together with Beckman Coulter Life Sciences to introduce Nanion’s patch clamp module into the Biomek […]

Just a couple of days ago, many of us woke up to find chocolates and gingerbread left by St. Nicholas. Now, as we’re finishing the last of these delicious treats (some of us couldn’t even resist enjoying them during meetings), let’s explore the intriguing science behind what makes them so irresistibly tasty. After all, it’s […]

Voltage-gated sodium channels (Nav) play a central role in generating and transmitting nerve signals. In humans, there are nine Nav subtypes (Nav1.1 to Nav1.9) which, to a large extent, share amino acid sequences but localize differently, suggesting specialized functions. The first member of the Nav family, Nav1.1, is predominantly expressed in inhibitory neurons, tuning down […]

When: 10.03. – 14.03.2024 Venue: Salt Palace Convention Center. 90 S. West Temple, Salt Lake City, UT 84101. Go to the Conference website here   Meet the Nanion Team Join Ronald Knox (Senior Business Executive, Nanion Inc.), Wyatt Hall (Director of Sales, Nanion Inc.) and the innoVitro team at SOT at booth #1832, to learn more […]

When: 22.02. – 23.02.2024 Venue: Senri Life Science Center Yuichi Yamamura Memorial Life Hall and Science Hall 1-4-2 Shin-Senri Higashimachi, Toyonaka, Osaka 560-0082, Japan Go to the Conference website here. Meet the Nanion Team in Japan Visit Mitsuyoshi Shimane (Application Support Manager), Takayuki Oka (Customer Support Manager), and Tomoyuki Inoue (Sales Representative) at Booth #21 for the 15th […]

When: 10.02. – 14.02.2024 Venue: Pennsylvania Convention Center, Philadelphia, PA Go to the Conference website here Live demos everyday- Visit us at booth #526! Posters  Sunday, February 11th Poster 1: Effects of mexiletine and its pyrroline derivative on NaV1.4 and NaV1.5 by Automated Patch Clamp Presenting author: Ali Obergrussberger Time: 1:45 PM (PST) Location: Exhibit Hall AB […]

When: 03.02. – 07.02.2024 Venue: Boston Convention and Exhibition Center. Boston, MA, USA Go to the Conference website here   Meet the Nanion Team Join Rodolfo Haedo (COO, Nanion Inc), Wyatt Hall (Director of Sales, Nanion Inc), and Ronlad Knox (Senior Business Executive) to learn more about our automated devices to research Ion Channels, Membrane Transporters, Pores and […]

When: 31.01. – 02.02.2024 Venue:  Grindelwald, Switzerland Go to the Conference website here   Meet the Nanion Team Join Markus Rapedius (Senior Scientist/Product manager Chips) and Fitzwilliam Seibertz (Scientific Sales) to learn more about our Automated Patch Clamp devices. Whether you are researching channelopathies, screening compound libraries, investigating biophysical properties and stimuli of ion channels, or […]

When we think of blood groups, the familiar A, B, O, and AB categories, along with the Rh factor, often come to mind. However, the world of blood groups is far more complex and diverse than these primary types. In fact, the International Society of Blood Transfusion now recognizes 45 blood group systems comprising 360 […]

Traditionally, nanopore research relies on electrical measurements to study the passage of materials, and these methods have been instrumental in understanding how various chemical species, including ions, small molecules, and polymers, interact with nanopores. However, it appears there are situations when certain molecules pass through nanopores without producing any detectable electrical signature, thus leaving no […]

Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, poses a significant challenge in pediatric oncology due to its aggressive metastatic behavior and drug resistance. Despite many advancements, RMS, especially in its advanced stages, lacks effective therapeutic strategies. The rarity of this disease (approximately 350 cases per year in North America) does not help […]

Malignant Migrating Partial Seizure of Infancy (MMPSI) is a severe, rare form of infantile epilepsy characterized by pharmacoresistant seizures and significant cognitive impairments. This devastating neurological disorder typically manifests within the first six months of life, often leading to profound developmental delays and, in 25% of cases, mortality within the first year. Sadly, to date, […]

Brugada Syndrome (BrS) is a rare, inherited cardiac arrhythmia often leading to syncope or cardiac arrest due to ventricular tachycardia or fibrillation. Primarily affecting young individuals without apparent heart structural issues, BrS can lead to fatal outcomes, often striking unexpectedly during rest or sleep. The hallmark of BrS is an abnormal ST segment elevation on […]

β-adrenergic receptor antagonists (β-blockers) are common medications for heart diseases like hypertension and heart failure. One of these β-blockers, carvedilol, has proven particularly effective in the treatment of heart failure, although the mechanisms responsible for this are controversial. Similar to other β-blockers, the primary action of carvedilol is to counter the excessive stimulating effects of […]

The importance of being able to quickly and accurately analyse cellular behaviour cannot be overstated. There are many key areas where this field of research makes the most vital difference today (and countless applications within each). Let us highlight some of them.     The first is biomedical research where the study of cells contributes […]

The discovery of PIEZO channels in 2010 marked a turning point in mechanobiology research, leading numerous teams to study the role of these channels in various physiological and pathological processes. Since then, numerous publications have confirmed the key role of PIEZO channels in mechanosensitivity across species. Dysfunctions in Piezo1 and Piezo2 have been found to […]

For years, the chloride intracellular channel protein 6 (CLIC6) has been a protein of mystery. Recognized for its association with various cancers and interactions with dopamine receptors, CLIC6’s role as an ion channel remained elusive, with conflicting evidence from different studies. CLIC6 is part of the distinctive family of non-canonical chloride intracellular channels (CLICs) exhibiting […]

There are probably no people in the world nowadays who haven’t heard about the COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, an abbreviation for “Severe Acute Respiratory Syndrome Coronavirus 2.” This global pandemic, which began in 2019, has claimed millions of lives and disrupted the socio-economic fabric of societies worldwide. The capacity of SARS-CoV-2 […]

Efficient and targeted sperm motility is crucial for the reproductive success of animals. To regulate their motility, sperm cells utilize a highly conserved signaling pathway involving several steps: hyperpolarization of the flagellar membrane, alkalinization of the sperm cytosol, increased cAMP production, and subsequent activation of the CatSper Ca2+ channel driving chemotaxis. In this pathway, alkalinization […]

When: 06.11. – 09.11.2023 Venue: Freiburg im Breisgau, Germany Go to the Conference website here.   Meet the Nanion Team Join Conrad Weichbrodt (Product Manager of Orbit product family) and Michael George (CTO) to learn more about our portfolio in Membrane Biophysics that offers sophisticated solutions for ion channels and membrane transporters research, drug discovery, assay development […]

When: 07.11. – 08.11.2023 Venue: London, UK Go to the Conference website here.   Meet the Nanion Team Join Giovanna De Filippi (Business Development Manager) and Martin Ziller (Development Engineer) at booth #35 to learn more about our Cells Analytics platforms that offer fast, label-free, and real-time cellular readouts such as impedance assays, extracellular electrical activity, and […]

Plants, like all organisms, require energy to grow. They obtain this energy by converting light into a usable chemical form through photosynthesis, producing carbohydrates such as sucrose. This sucrose, the primary product of photosynthesis, is then transported to non-photosynthetic sink organs (e.g., flowers, seeds, and roots) to support their growth and development. Efficient transport of […]

When: 11.11 -15.11.2023 Venue: Walter E. Washington Convention Center Washington DC, USA Go to  the Conference Website Here.   Join Rodolfo Haedo (COO, Nanion, Technologies), Dr. Alison Obergrussberger (Scientific Communications Manager, Nanion Technologies), Dr. George Okeyo (Vice President, Nanion Technologies), & Dr. Irene Lu (Application Scientist) at booth #2525 to learn more about our Automated […]

Cannabis, often referred to as marijuana, has been utilized by humans for thousands of years for medical purposes … and beyond. You’ve probably heard of tetrahydrocannabinol (THC, that same well-known psychoactive component of marijuana that makes people feel ‘high’) and cannabidiol (CBD), a major phytocannabinoid which has proven to be such an effective anticonvulsant that […]

The aquatic environment is rich in bacteria, and therefore fish have developed a variety of defense strategies to protect themselves from potential bacterial threats. For example, fish have a slimy mucus layer covering their skin, which serves as a physical barrier against bacteria. Fish also produce small proteins called antimicrobial peptides (AMPs) in their mucus […]

TMEM175 has recently been recognized as a potential therapeutic target for the treatment of Parkinson’s disease. This interview with David Stone will provide you insights into what makes TMEM175 a particularly interesting drug target. You’ll also learn about some recent advances and challenges in the development and application of TMEM175 screening assays. David Stone is […]

Mutations or variants in the voltage-gated sodium channel SCN2A (NaV1.2) have been associated with various neurodevelopmental disorders. The existing paradigm suggests that gain-of-function (GoF) SCN2A variants lead to neonatal-onset epilepsy, while loss-of-function (LoF) variants are linked to autism spectrum disorder (ASD) and intellectual disability (ID). In the recent study, Thompson et al. challenge this binary […]

When: 10.10. – 12.10.2023 Venue: Hall 1, Messe Basel, Switzerland Go to the Conference website here.   Meet the Nanion Team Join Niels Fertig (CEO, Nanion Technologies), Sonja Stoelzle-Feix (Director of Scientific Affairs, Nanion Technologies), Giovanna De Filippi (Business Development Manager, Nanion Technologies) and Matthias Gossmann (CEO, innoVitro) at booth #912 to learn more about […]

When: 18.10. – 19.10.2023 Venue: Liverpool, UK Acc Liverpool Exhibition Center Go to the Conference website here.   Meet the Nanion Join Dr. Alison Obergrussberger (Scientific Communication Manager) and Giovanna De Filippi (Business Development Manager) to learn more about our Automated Patch Clamp platforms that offers sophisticated solutions for the study of ion channels, drug […]

日時: 11月7日、10時～17時30分 場所: TWIns 懇親会: 18時～ 京王プラザホテル     この度、ナニオンテクノロジーズジャパン株式会社は東京女子医科大学と共同で、4年ぶりとなる対面でのイオンチャネルフォーラム2023を開催する運びとなりました。 本フォーラムが産学の枠を超えた意見交換の場となり、イオンチャネルをはじめとした膜たんぱく質研究および再生医療研究の発展に貢献できることを切に願っております。 フォーラム後には、ささやかながら都内ホテルにて懇親会も開催いたします。 また、翌日には弊社各種製品を使用した電気生理のワークショップも開催予定です。 ご多忙の折とは存じますが、是非ご来場下さいますようご案内申し上げます。

When: 24.10. – 25.10.2023 Venue: Nanion Technologies Headquarters. Munich, Germany Join us at the Nanion User Meeting 2023   Over the years, Nanion has grown and built a community constituted by our customers and collaborators that join us every year at the Nanion User Meeting (NUM) to discuss the latest updates in of drug discovery, […]

When: 11.05.-12.05.2023, from 8:00 AM until 5:30 PM each day. Venue: The Battery Wharf Boston Waterfront, Boston, MA 02109, United States Join us at the Nanion User Meeting in Boston Massachusetts Over the years, Nanion has grown and built a community constituted by our customers and collaborators (that also became our friends) that join us […]

September is Atrial Fibrillation Awareness Month! We at Nanion Technologies would like to take this opportunity to emphasize the importance of research on this serious medical condition and to highlight the recent work done by researchers from the University of Göttingen. Atrial fibrillation is one of the most common types of cardiac arrhythmias. It’s a […]

Despite the fact that the normal body temperature hovers around 37°C, most electrophysiological studies on ion channel function are conducted at room temperature, typically ranging from 18°C to 25°C. While such a temperature is absolutely physiological for some channels (such as those located at nerve endings in the skin), it is certainly not the case […]

Planar patch clamp chips have revolutionized the field of electrophysiology by enabling researchers to study cellular electrical activity in a faster, more efficient, and higher-throughput manner. As we now see a growing interest from our customers in the development of chips for specific applications, we believe it would be very useful if we could guide […]

When: 25.09. – 29.09.2023 Venue: Shizouka Convention and Arts Center (GRANSHIP) 2-3-1 Higashishizouka, Suruga-ku, Shizouka 422-8019 Japan Go to the Conference website here.   Meet the Nanion Japanese Team  Join team Japan at “2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the […]

In recent years, TMEM175 has emerged as a promising therapeutic target for the treatment of Parkinson’s disease. This lysosomal ion channel has been shown to play an essential role in maintaining lysosomal pH and function. Although originally identified as a potassium leak channel, recent studies suggest that TMEM175 is, in fact, a proton-activated, proton-selective channel. […]

Proton-dependent oligopeptide transporters play a vital role in allowing a variety of dietary peptides and orally taken peptidomimetic drugs to enter cells. Given their clinical and pathophysiological significance, these transporters are extensively studied nowadays, yet the exact way they recognize and transport different types of peptides is not completely understood. In a very recent study […]

When:  07.09.2023 at 16:00 h CEST (10:00 AM EDT) Venue: via Zoom

When: 04.10. -06.10.2023 Venue: University Hospital Tübingen, CRONA Klinikum, Large Lecture Hall 210, Level 4, Building 420. Tübingen, Germany Go to the Conference website here.   Meet Dr. Ali Obergrussberger Join Dr. Ali Obergrussberger (Scientific Communication Manager) to learn more about our Automated Patch Clamp platforms that offers sophisticated solutions for the study of ion channels, drug […]

When: 01.10. -04.10.2023 Venue: Volpriehausen, Germany Landhotel Am Rothenberg, Rothenbergstraße 4 Go to the Conference website here.   Meet Dr. Fitzwilliam Seibertz Join Dr. Fitzwilliam Seibertz (Scientific Sales) to learn more about our Automated Patch Clamp platforms that offers sophisticated solutions for the study of ion channels, drug discovery, assay development and more. Contact us to […]

When: 06.09.2023 Venue: Main building, Lecture hall A 003, of the UniS of the university of Bern located at Schanzeneckstrasse 1, 3012 Bern. Go to the Conference website here. Meet Dr. Søren Friis Join Dr. Søren Friis (Director Global Customer Relations) to learn more about the solutions we offer study ion channels and membrane transporters. COntact Soren to […]

When: 13.09. – 15.07.2023 Venue: Congress Center of “Federico II”, University of Naples Aula Magna Partenope. Naples, Italy. Go to the Conference website here.   Meet the Nanion team Join Dr. Kefan Yang (Application Scientist) and Dr. Fitzwilliam Seibertz (Scientific Sales) at booth #5 to learn more about our Automated Patch Clamp platforms that offers sophisticated solutions […]

When: 17.09. – 20.09.2023 Venue: Sete, France. Go to the Conference website here.   Meet Dr. Artem Kondratskyi Join Artem (Scientific Solutions Manager) to learn more about our Automated Patch Clamp platforms that offer sophisticated solutions for the study of ion channels, drug discovery, assay development and more. Visit Artem at booth #TBD. Nanion will […]

When: 18.09. – 21.09.2023 Venue: SQUARE Brussels Meeting Centre, Brussels, Belgium. Go to the Conference website here.   Meet the Nanion Team at SPS Join Niels Fertig, Sonja Feix-Stölzle, Rodolfo Haedo and Ronald Knox at booth #208 to learn about our CiPA certified platforms and how we can help you accelerate your research. We will […]

When: 21.09. – 23.09.2023 Venue: Henry Ford Building. Freie Universität Berlin Garystraße 35. 14195 Berlin-Dahlem Go to the Conference website here.   Meet the Nanion team Join Dr. Yeimar Portillo (Marketing and Sales Associate) at booth #7 to learn about the solutions we offer for Automated Patch Clamp, Membrane Biophysics, and Cell Analytics research. Get […]

When: 27.10. – 01.10.2023 Venue: Marine Biological Laboratory in Woods Hole. MA, USA Go to the conference website here. Society of General Physiologist Annual Meeting (SGP) 2023 Nanion is a proud sponsor of the SGP Excelsior Award. Deadline closes on 01.07.2023 Find more information on how to apply here.   More information will follow soon… […]

When: 27.09. – 29.09.2023 Venue: Palais Niederösterreich. Vienna, Austria. Go to the Conference website here.   Meet the Nanion SSM-based Electrophysiology team Join Dr. Cecilia George (Senior Sales Manager SURFE2R / Senior Scientist), Dr. Andre Bazzone (Senior Scientist) and Rocco Zerlotti (Ph.D. Student) at booth #TBD to learn about the solutions we offer in Membrane Biophysics for […]

When: 04.09. – 07.09.2023 Venue: Plymouth. Marine Biological Association Go to the Conference website here.   Meet Dr. Kefan Yang Join Dr. Kefan Yang (Application Scientist) on the workshops using the semi-automated patch clamp system, Port-a-Patch, and lipid bilayer system, Orbit mini. Both systems offer sophisticated solutions for the study of membrane ion channels and […]

When: 04.09. – 06.09.2023 Venue: SuperC building of RWTH Aachen University. Aachen, Germany. Go to the Conference website here. Meet Dr. Giovanna De Filippi Join Dr. Giovanna De Filippi (Business Development Manager) to learn more about our Cell Analytics platforms. Contact Giovanna to learn about the instruments we offer to perform fast, label-free, and real-time […]

When: 31.08. – 03.09.2023 Venue: Alicante, Spain. Go to the Conference website here. Meet Dr. Markus Rapedius Join Dr. Markus Rapedius (Product Manager NPC-384 Chips) to learn more about our Automated Patch Clamp platforms that offers sophisticated solutions for ion channels study, drug discovery, assay development and more. Contact Markus to learn how Nanion can […]

For the 20th anniversary of the Port-a-Patch, we are delighted to present an exclusive interview with our CEO, Niels Fertig. A visionary leader and innovator, Niels will take us on a voyage through time, unraveling the story behind this revolutionary patch clamp system that has transformed the field of electrophysiology.   “Thank you for joining […]

When: 20.07.2023, 15:00 – 16:00 h CEST Venue: via Zoom   Webinar: TMEM175 screening on the SURFE²R TMEM175 is a lysosomal ion channel playing a critical role in maintaining lysosomal pH and function, which is important for various cellular processes, such as autophagy, lysosomal exocytosis, and protein degradation. Dysfunctional lysosomes and impaired autophagy have been […]

When: 13.07.2023, 17:00 h CEST Venue: via Zoom Webinar – Diverse applications of high throughput APC in academic research Speakers: Dr. Elena Govorunova (Center for Membrane Biology, UTHealth McGovern Medical School) presenting about “Using the SyncroPatch 384 to characterize light-gated ion channels“ Dr. Alfred L. George, Jr. (Department of Pharmacology. Northwestern University Feinberg School of […]

When: 14.06.2023, 15-16 h CEST Venue: via Zoom Webinar: Golden years of semi-automated patch clamp This webinar will give you insights on the tools available to study ion channels using semi-automated patch clamp, its potential in assay development and drug discovery and the relevance of patch clamp nowadays. Join Dr. Patrick Mumm, Parsa Arman, MS., […]

When: 19.06. – 21.06.2023 Venue: Pacifico Yokohama. 1 Chome-1-1 Minatomirai, Nishi Ward, Yokohama, Kanagawa 220-0012, Japan Go to the conference website here. Meet us at the JSOT 2023 Visit Mitsuyoshi Shimane (Application Support Manager), Takayuki Oka (Customer Support Manager), and Tomoyuki Inoue (Sales Representative) at Booth #18 for the The 50th Annual Meeting of the Japanese […]

When: 25. – 30.06.2023 Venue: The Grand Hotel Malahide. Grove Road, Malahide, Ireland. Go to the Conference website here   Nanion is proud to sponsor “The Calcium and Cell Function Conference 2023” Automated patch clamp has been used to study calcium signaling in various cell types including neurons, cardiomyocytes, among others. In calcium signaling research, Automated […]

When: 12. – 14.06.2023 Venue: Copenhagen, Denmark. Go to the Conference website here   Meet Dr. Elena Dragicevic Join Dr. Elena Dragicevic (Global Marketing Manager) to learn more about our Cell Analytics platforms that offers sophisticated solutions for cardiac research, as well as our Automated Patch Clamp instruments with high throughput to study the electrophysiological behavior […]

When: 15. – 17.06.2023 Venue: Rosensäle Universität Jena. Jena, Germany. Go to the Conference website here. Meet Dr. Yeimar Portillo Join Dr. Yeimar Portillo (Marketing and Sales Associate) to learn more about our product portfolio in Automated Patch Clamp, Cell Analytics, and Membrane biophysics. Contact us to learn how Nanion can help you accelerate your research. […]

When: 16. – 17.06.2023 Venue: London, UK. Go to the Conference website here   Meet Dr. Cecilia George  Join Dr. Cecilia George (Senior Sales Manager SURFE2R / Senior Scientist) to learn more about our SURFE2R technology that offers sophisticated solutions for transporters research, as well as our Membrane biophysics technology to study the conduction behavior of […]

When: 12.08. – 15.08.2023 Venue: Vila Nova de Gaia, Portugal. Go to the Conference website here.   Meet Dr. Andre Bazzone and Rocco Zerlotti Join Dr. Andre Bazzone (Senior Scientist) and Rocco Zerlotti (Ph.D. student) to learn more about our Solid Supported Membrane (SSM)-based Electrophysiology platforms, SURFE2R N1 and SURFE2R 96SE, that offer sophisticated solutions […]

When: 18. – 23.06.2023 Venue: Les Diablerets Conference Center Eurotel Victoria, Switzerland Go to the Conference website here   Nanion is proud to sponsor this conference  

When: 07.07.2023 Venue: Munich, Germany Go to the Conference website here.   Meet the Nanion team at the Symposium Dr. Kefan Yang (Application Scientist), Dr. Yeimar Portillo (Marketing and Sales Associate), Dr. Markus Rapedius (Product Manager 384 Chips), and Dr. Elena Dragicevic (Global Marketing Manager) are excited to meet you at the symposium and hear the […]

When: 10.07. -12.07.2023 Venue: Harrogate Convention Centre, North Yorkshire, UK Go to the Conference website here.   Meet Dr. Ali Obergrussberger Join Dr. Ali Obergrussberger (Scientific Communication Manager) to learn more about our Automated Patch Clamp platforms that offers sophisticated solutions for ion channels study, drug discovery, assay development and more. Contact Ali Obergrussberger to learn […]

When: 31.07. – 04.08.2023 Venue: Aula Magna, Frescativägen 6, 114 18 Stockholm. Go to the Conference website here. Meet us Join Dr. Conrad Weichbrodt (Product Manager of Orbit product family) and Dr. Cecilia George (Senior Sales Manager SURFE2R / Senior Scientist) to learn more about our portfolio in Membrane Biophysics that offers sophisticated solutions for […]

When: 06.08. -11.08.2023 Venue: Rey Don Jaime Grand Hotel. Avinguda de l’Hotel. Castelldefels, B, Spain. Go to the Conference website here.   Meet Dr. Markus Rapedius Join Dr. Markus Rapedius (Product Manager 384 Chips) to learn more about our Automated Patch Clamp platforms that offers sophisticated solutions for ion channels study, drug discovery, assay development and […]

When: 24.08. -25.08.2023 Venue: University of St Andrews, UK. Go to the Conference website here.   Meet Dr. Ali Obergrussberger Join Dr. Ali Obergrussberger (Scientific Communication Manager) to learn more about our Automated Patch Clamp platforms that offers sophisticated solutions for ion channels study, drug discovery, assay development and more. Contact Ali Obergrussberger to learn how Nanion can […]

When: 24.05.2023 Venue: Zoom (this is a virtual symposium)   Join us at the Cardiac Safety Symposium 2023 After its success in 2021, we are back with the Cardiac Safety Symposium where you can learn about newest insights on current challenges in safety pharmacology, cardiac physiology, electrophysiology and contractility assessments of stem cell-derived and native […]

When: 27.05.2023 Venue: Nagoya University Higashiyama Campus Noyori Memorial Academic Exchange Hall, Nagoya, Japan Go to the conference website here. Meet us at the JTRA Visit Mitsuyoshi Shimane (Application Support Manager) at Booth #N/A for the The 17th Annual Meeting of the Japan Transporter Research Association (JTRA). We will bring the SURFE2R N1 to perform demonstrations. […]

“Can you tell us a little about your research project. “   We have various projects in which we are researching TRP channels in connection with the development of possible therapies for eye diseases (including tumor diseases). Over the last 15 years, we were able to develop good approaches. One example is “dry eye disease” […]

“Can you tell us a little about your research project. “   Our research focuses on the function and pharmacology of P2X receptors, a family of ligand-gated cation channels activated by extracellular ATP.   “You have been using the Port-a-Patch since 2016. Tell us about your experience working with Nanion and the Port-a-Patch. What are […]

“Assay.Works was the first CRO to acquire the SURFE²R 96SE platform. What are the main benefits of the platform that made you acquire it?” Some targets such as organelle transporters that can be readily and in high-throughput format studied using SURFE²R 96SE, are inaccessible for other techniques. Assay.Works is delighted to have a long-lasting close […]

“Can you tell us about your research project.” My PhD project has revolved around the characterization of structure and function of a glutamate transporter homologue from a thermophilic archaea, namely GltTk. This transporter has been historically used for studying the more complicated human homologues which are involved in the regularization of glutamate concentration in the […]

Diverse (ity), yes we are.

When: 16.05. – 18.05.2023 Venue: WINC AICHI. Nagoya, Japan Go to the conference website here. Meet us at the APSTJ38 Visit Mitsuyoshi Shimane (Application Support Manager), Takayuki Oka (Customer Support Manager), and Tomoyuki Inoue (Sales Representative) at Booth #N for the The 38th Annual Meeting of the Academy of Pharmaceutical Science and Technology, Japan. We […]

When: 10.05.2023 Venue: Babraham Research Campus Conference Centre, Cambridge, UK Go to the Conference website here Meet Dr. Alison Obergrussberger and Dr. Elena Dragicevic Contact Alison Obergrussberger (Scientific Communication Manager), and Elena Dragicevic (Senior Sales and Alliance Manager) to learn how our technology can help you accelerate your research. Nanion will be present with posters: More […]

We are happy to share the publication and video about the CardioExcyte 96 / FLEXcyte 96 hybrid cell analysis system published in JoVE with our partners from innoVitro. Read the article to find out how to cover contractility, cell viability and extracellular field potential recordings in one hybrid system for preclinical cardiac risk assessment. Publication: […]

When: 30. – 31.03.2023 Venue: Christian-Albrechts-Universität zu Kiel, Hermann-Rodewald-Straße 5, 24118 Kiel Go to the Conference website here   Nanion Workshop Title: “Measure More Membrane” What will you learn? To do Patch-Clamp Recordings and the usage of Pharmacological Modulators. Understand how to interpret Data in physiological context. When: 30.03.2023 at 15h. Hosts: – Markus Rapedius, Nanion […]

When: 27. – 28.03.2023 Venue: Hinxton Hall, Wellcome Genome Campus, Cambridge. Go to the Conference website here Meet Dr. Alison Obergrussberger and Dr. Elena Dragicevic Join Alison Obergrussberger (Scientific Communication Manager), and Elena Dragicevic (Senior Sales and Alliance Manager) at booth #2 to learn how our technology can help you accelerate your research. Nanion will be […]

When: 19.-23.03.2023 Venue: Nashville Music City Center in downtown Nashville, Tennesse Join us at the SOT 62nd Annual Meeting and ToxExpo Visit us at booth #543 and meet Ronald Knox (Nanion Senior Business Executive) and our friends from innoVitro at the SOT meeting and learn about AtlaZ hepatotox-screening on FCDI hepatocytes. Information about the poster […]

We bring you demonstrations of a selection of instruments on the virtual reality space.

When: 14. – 17.03.2023 Venue: Escandilles Villages Vacances in Autrans-Méaudre in the “Parc Naturel Régional” of the Vercors. Austrans, France. Go to the Conference website here Meet Dr. Conrad Weichbrodt Join Dr. Conrad Weichbrodt (Senior Scientist / Product Manager Orbit family) who will be showcasing our Orbit technology at the booth.   Synopsis of the GEM […]

When: 16. – 18.03.2023 Venue: Deutsches Zentrum für Herzinsuffizienz Würzburg (DZHI) Universitätsklinikum Würzburg Am Schwarzenberg 15, Haus A15 97078 Würzburg Go to the Conference website here   Meet Dr. Elena Dragicevic and Martin Ziller  Join Dr. Elena Dragicevic (Senior Sales and Alliance Manager), and Martin Ziller (Development Engineer) at booth # to learn more about our […]

When: 25.02 – 01.03.2023 Venue: San Diego Convention Center, 111 W Harbor Drive, San Diego, CA 92101 Go to the Conference website here   Live demos everyday- Visit us at booth #1303!   Meet us Meet Wyatt Hall and Tim Strassmeier Join Nanion Director of Sales (USA), Wyatt Hall, and Director of Scientific Operations (USA), Dr. […]

When: 18. – 22.02.2023 Venue: San Diego Convention Center, 111 W Harbor Drive, San Diego, CA 92101 Go to the Conference website here Live demos everyday- Visit us at booth #529!   Nanion Exhibitor Presentation Attend our symposium: Title: Need for speed: No limits for automated electrophysiology Monday, February 20th 2023, 9:30 AM – 11:00 AM Room […]

When: 17. – 18.02.2023 Venue: Yayoi Auditorium, The University of Tokyo, Ichijo Hall 113-0033Bunkyo7-3-1 Hongo Go to the Conference website here. Meet the Nanion Team in Japan Visit us at Booth H for networking and learn more about our products. Our Team will be present with FLEXcyte 96, Port-a-Patch mini, Orbit mini and the Vesicle Prep Pro. If you […]

When: 16. – 17.02.2023 Venue: University of Zurich. Campus Irchel. Winterthurerstrasse 190, 8057, Zurich. Go to the Conference website here Nanion Presentation Join us for the Industry talk at the Parallell Symposia Session II: “Understanding the Role of Ion Channels and Membrane Transporters in Cardiac and Renal Diseases” Friday, February 17th 2023, 10:20 AM – 12:05 […]

We demonstrate for the first time successful recordings of all expected ion channel currents and action potentials from freshly isolated mammalian atrial and ventricular cardiomyocytes on the SyncroPatch 384.

The SyncroPatch 384 has been installed at the MBExC Cluster of Excellence at the University Medical Centre Göttingen (UMG).

From a logic gate for ultrafast electronics to miniaturized optical data links – Nano Innovation Award 2022   Munich, Germany, July 22nd 2022: LMU Center for NanoScience and four spin-off companies jointly honor innovative PhD students Three PhD students from Erlangen, Würzburg and Munich were honored this year with the Nano Innovation Award. The prize for […]

SyncroPatch 384 instrument has been installed at the FDA

Nanion is pleased to announce the launch of the SyncroPatch 384.

Assessing preclinical cardiac contractility without animal use

This video shows the CardioExcyte 96, a hybrid system recording both impedance and electrophysiology (extracellular field potential, EFP) from intact iPSC-derived cardiomyocyte networks.

Nanion announces the partnership with NEXEL Co., Ltd.

Nanion is pleased to announce the launch of the Port-a-Patch mini

Nanion announces its partnership with Assay.Works,

This video looks into external solution exchange and compound addition on the SyncroPatch 384PE and SyncroPatch 384i.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

Diverse (ity), yes we are.

This Igor video tutorial for Patchliner data analysis demonstrates how concentration-response curves are quickly displayed and analyzed.

“Just because it hasn´t been done, doesn´t mean it can´t!”

“Science is expensive, it´s a chronic problem and this is why funding is so important”

“If you like the journey, it becomes enjoyable and you come up with new ideas to table problems”

“Be excited about the research, everything else will naturally follow”

“The significance of membrane traffic- structural studies of phosphoinositide signaling”

“Passion from an early age in arachnid venom”

“What to expect during the early stages of your Ph.D. rotation program”

“You build your career based on the inspirational scientists you encounter along the way”

“A glimpse into the future of drug screening”

“A closer look at the NALCN channel”

“DNA Nanotechnology, DNA Origami, and Lipid vesicles: Constructing a living cell from bottom up”

“A closer look at the red blood cells and neuroacanthocytosis”

“A glance at Alzheimer´s disease and the role of ion channels”

“From MASc in Biomedical Engineering to the world of finance and back”

“Bacterial ion channels have emerged as new target for developing new antibiotics and combat the problem of multi-drug resistance”

The Orbit mini is a miniaturized bilayer workstation for recording from 4 bilayers simultaneously. Watch how to prepare membranes for the Orbit mini: 1. Take e.g. a 10 μl Eppendorf pipette (small white tip) 2. Cover the tip with lipids by dipping it into the lipid stock solution without aspirating any of it. Due to […]

Orbit Mini – Plug and Paint: For Planar Lipid Bilayers Simultaneous recording from four lipid bilayers Low noise, high bandwidth recordings Temperature control – active cooling and heating Cost-efficient experiments with disposable MECA chips