Customer Opinion –

Samuel Fountain

“Can you tell us a little about your research project. “


Our research focuses on the function and pharmacology of P2X receptors, a family of ligand-gated cation channels activated by extracellular ATP.


“You have been using the Port-a-Patch since 2016. Tell us about your experience working with Nanion and the Port-a-Patch. What are your impressions? “


The Port-a-Patch has been a highly reliable instrument for us. We have used it to record from cell lines, but also primary cells from human tissue. The instrument is used by those in my group whose main focus is electrophysiology, but also those who need to undertake shorter-term electrophysiological studies. The latter is enabled by the instrument’s accessibility and limited training requirement compared to manual patch-clamp.


“Which particular features of the Port-a-Patch accelerated your research and publications? “


The rapid perfusion system has been key for us studying the mode of action of drug-like molecules at ligand-gated ion channels. The internal perfusion system also allows for rapid exchange of intracellular components for the studies of regulator and signalling pathways. Working with small volumes is also useful when working small scales of experimental compounds, natural products, animal toxins and antibodies.


“How do you plan to use the Port-a-Patch in the future?”

We are currently using the instrument to explore heteromerization of P2X receptors, and to characterise the action of some new drug-like molecules targeting P2X4.


Learn more about Prof. Dr. Samuel Fountain and his research interests here and find more about his research on ReseachGate