Join us for an insightful webinar exploring the role of PepT2 in antibiotic transport

How do beta-lactam antibiotics enter the body, and how can we improve their delivery?

Join us for an engaging webinar exploring how key transporters shape the uptake and elimination of beta-lactam antibiotics in the human body.

The uptake and elimination of beta-lactam antibiotics are facilitated by the proton-coupled peptide transporters PepT1 (SLC15A1) and PepT2 (SLC15A2). However, the mechanism by which SLC15 family transporters recognize and discriminate between different drug classes and dietary peptides remains unclear, which limits efforts to improve antibiotic pharmacokinetics through targeted drug design and delivery.

Combining cryo-EM structures of PepT2 with liposome-based transport assays and molecular dynamics simulations, this talk will establish the mechanism of beta-lactam antibiotic recognition and highlight the important role of protonation in drug binding and transport.