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CardioExcyte 96

CardioExcyte 96 – Dr. Daniel Konrad

"Impedance and field potential data of beating cardiomyocytes is getting increasingly important to obtain a comprehensive view of the cardiac liability of test compounds. To answer these questions for our clients, B’SYS successfully implemented the CardioExcyte 96 system and provides related validated services to its customers, mostly using ipS derived cardiomyocytes. B’SYS’ scientists are pleased with the CardioExcyte’s ease of operation and data acquisition. The powerful software allows for applying meaningful data analysis and time saving export of data as needed for our daily customer reports."

Dr. Daniel Konrad, CEO, B'SYS
CardioExcyte 96 – Carlos Obejero-Paz MD, PhD

"The CardioExcyte 96 instrument is a great tool to interrogate the electrical properties and motion events of 2D cultures. At Khloris Biosciences we use human induced stem cell technology for cardiac disease modeling and cancer drug discovery. The CardioExcyte 96 instrument is a key component of the QC process. We use the instrument to determine the excitation-contraction coupling characteristics of stem cell derived cardiomyocytes from patients with distinct cardiopathies, and in cancer biology to phenotype cancer cell lines using impedance spectroscopy. The exchange of ideas with Nanion’s engineers was key to expand the use of the CardioExcyte 96 in these fields. I am looking forward to continuing this collaboration."

Carlos Obejero-Paz MD, PhD, Senior Scientist II, Khloris Biosciences
CardioExcyte 96 – Dr. Ralf Kettenhofen

"CardioExcyte 96 is an easy-to-use system, providing impedance-based and MEA-like cardiac safety data from a diversity of stem cell-derived cardiomyocytes, and constitutes an excellent complement to automated patch clamp-based safety screening. Concentration- and time-dependence of a compound’s potential cardiotoxicity can efficiently be obtained where the alteration of beating patterns can give a hint as to which cardiac ion channel(s) is affected, after which detailed electrophysiology investigations can be undertaken. Cardiac network responses offer a comprehensive view of a compound’s safety profile, without having to use in-vivo methods, which saves time, costs and suffering. Further on, the powerful software, used for recordings and analysis, employs comprehensive beat investigation algorithms, displaying detailed beating kinetics in real-time. Data handling and export is straightforward, easy to grasp and yet very, very powerful."

Dr. Ralf Kettenhofen, Head of Laboratory, Ncardia (previous position)

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