The NPC-384 chip is the cost-efficient and high quality consumable for the SyncroPatch 384. It is produced and quality-assured exclusively in-house at Nanion headquarters and shipped from Munich to our international customers. Different types of NPC-384 chips are available which should be chosen depending on cell size and application to maximize success rates. Recently, we developed dedicated fluoride-free chips (NPC384FF) for high throughput recordings in absence of internal fluoride.
Reference Publication: Rapedius and Obergrussberger et al., Front. Mol. Neurosci. 2022
Each well of the 384-well plate of the NPC-384 chip has one (or multiple) apertures for cell capture and recording. The pipette adds solution close to the patch clamp aperture and the solution can be removed from the external side of the well by the pipette. The internal solution is supplied via a perfusion system and solution can be exchanged whilst continuously recording.
Reliable buffer solutions are critical for any electrophysiological application. Our goal, therefore, is to provide high-class recording solutions that leave you in no doubt about quality and stability. Our quality assurance includes chemical tests as well as tests on our patch clamp systems of each lot. Our buffers are shipped with the corresponding "Certificates of Analysis" and "Material Safety Data Sheets" (MSDS).