AtlaZ

The AtlaZ brings in vitro cell analytics to a new dimension. It is an advanced system designed for quantitative live-cell analysis. It provides researchers with the capability to investigate various cellular aspects, including cell adhesion and proliferation, cytotoxicity, GPCR (G-protein coupled receptor) signaling, morphology, and barrier function in real-time. Importantly, these measurements are label-free, eliminating the need for external dyes or markers.

With the AtlaZ system, recordings can be conducted simultaneously or independently in up to six 96-well plates. This high throughput capability, combined with the underlying methodology of powerful electrical impedance spectroscopy (EIS), offers researchers valuable insights into cellular behavior and responses on a scale that was previously unattainable. AtlaZ measures and analyzes the electrical impedance parameters across a range of frequencies (from 0.1 kHz – 100 kHz), such as impedance magnitude and phase, resistance, and capacitance.

A crucial advantage over standard assays using labels or dyes, is the continuity of cell monitoring. Endpoint assays are labor-intensive and lack kinetic information of the recorded effects. AtlaZ uses unique culture plates with integrated electrodes which enable long-term measurements over several weeks. Thus real-time data on cell adhesion, proliferation and compound effects can be acquired. Ready-to-go Recording Modes with automated graphing of results are available for ease-of-use, while running a full spectrum provides understanding about various cellular mechanisms, such as cell death.