• Nanion技术: 离子通道研究的智能工具

    Nanion技术: 离子通道研究的智能工具

  • SyncroPatch 384i: HTS Automated Patch Clamp

    SyncroPatch 384i: HTS Automated Patch Clamp

  • SURFE²R 96SE: 非标记高通量转运体筛选

    SURFE²R 96SE: 非标记高通量转运体筛选

  • Dynamic Clamp: Patchliner

    Dynamic Clamp: Patchliner

  • 脂双层记录: Orbit产品系列

    脂双层记录: Orbit产品系列

  • CardioExcyte 96 SOL:用光遗传的手段起搏心肌细胞

    CardioExcyte 96 SOL:用光遗传的手段起搏心肌细胞

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SyncroPatch 384i

SyncroPatch 384i

Patchliner

Patchliner

Port-a-Patch

Port-a-Patch

Port-a-Patch mini

Port-a-Patch mini

CardioExcyte 96

CardioExcyte 96

FLEXcyte 96

FLEXcyte 96

SURFE²R 96SE

SURFE²R 96SE

SURFE²R N1

SURFE²R N1

Orbit 16

Orbit 16

Orbit Mini

Orbit Mini

Vesicle Prep Pro

Vesicle Prep Pro

07.06.2016 | External Webinar: A new analysis capability to improve assessment of cardiac liability in high throughput electrophysiology

icon sp96   SyncroPatch 384PE (a predecessor model of SyncroPatch 384i)

AstraZeneca has implemented the Nanion SyncroPatch 384PE electrophysiology platform. This webinar will show how AstraZeneca and Genedata developed a processing and analysis pipeline for the complex data, reading binary raw data directly from the instrument into Genedata Screener.
Organisation: Genedata AG.

Speakers:

Ana Teixeira and Matthew Bridgelend-Taylor, AstraZeneca, Cambridge, UK

Description:

Automated patch clamp screens generate highly valuable information for drug research programs. Therefore, AstraZeneca has implemented the Nanion SyncroPatch 384PE electrophysiology platform, capturing full kinetics of channel response at higher throughput for hERG and other key cardiac ion channels. AstraZeneca and Genedata then developed a processing and analysis pipeline for this complex data, reading binary raw data directly from the instrument into Genedata Screener, then assigning and integrating the sweep recordings and finally subjecting them to scientists’ review. Additional methods to normalize the cumulative curve recordings and to automatically detect “slow onset” compounds were developed. This investment in a next-generation automated electrophysiology platform and an appropriate automated data processing pipeline is resulting in more predictive and affordable safety screens at high scalability and rapid turnover for discovery projects across AstraZeneca.


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