CaV1.2 - Current Voltage Relationship
SyncroPatch 384PE (a predecessor model of SyncroPatch 384) data and applications:
Cells kindly provided by Charles River.
CaV1.2 expressed in CHO cells recorded on the SyncroPatch 384PE (a predecessor model of SyncroPatch 384). A The screenshot shows the data acquisition and analysis software used on the SyncroPatch 384PE. The online analysis values are shown for a current-voltage experiment. B The raw traces from an example cell elicited by depolarizing steps from -60 mV to 40 mV in 10 mV increments from a holding potential of -80 mV are shown. C The normalized current-voltage plot for an average of 272 cells. A Boltzmann equation fit revealed a V0.5 of activation of -4.8 mV.
![27.06.2022: Publication Alert - Discovery of agonist–antagonist pairs for the modulation of Ca [2]+ and voltage-gated K+ channels of large conductance that contain beta1 subunits](/images/Images_tiff_jpg_png/Corporate_Blog_Press_Releases/220627_blog_image_Discovery%20of%20agonist–antagonist%20pairs%20for%20the%20modulation%20of%20Ca2+%20and%20voltage-gated%20K+%20channels%20of%20large%20conductance%20that%20contain%20beta1%20subunits.jpg)
