• Nanion技术: 离子通道研究的智能工具

    Nanion技术: 离子通道研究的智能工具

  • SyncroPatch 384i: HTS Automated Patch Clamp

    SyncroPatch 384i: HTS Automated Patch Clamp

  • SURFE²R 96SE: 非标记高通量转运体筛选

    SURFE²R 96SE: 非标记高通量转运体筛选

  • Dynamic Clamp: Patchliner

    Dynamic Clamp: Patchliner

  • 脂双层记录: Orbit产品系列

    脂双层记录: Orbit产品系列

  • CardioExcyte 96 SOL:用光遗传的手段起搏心肌细胞

    CardioExcyte 96 SOL:用光遗传的手段起搏心肌细胞

我们的产品目录

SyncroPatch 384i

SyncroPatch 384i

Patchliner

Patchliner

Port-a-Patch

Port-a-Patch

Port-a-Patch mini

Port-a-Patch mini

CardioExcyte 96

CardioExcyte 96

FLEXcyte 96

FLEXcyte 96

SURFE²R 96SE

SURFE²R 96SE

SURFE²R N1

SURFE²R N1

Orbit 16

Orbit 16

Orbit Mini

Orbit Mini

Vesicle Prep Pro

Vesicle Prep Pro

Mitochondria - "Mitoplasts from HEK cells on Nanion‘s Port-a-Patch"

icon pap   Port-a-Patch application note   logo pdf   (0.5 MB)

Summary:

Mitochondria play an important role in metabolism by providing the cell with ATP due to oxidative phosphorylation. But they are also supposed to be involved in apoptosis and cytoprotection. The mitochondrial membranes contain a large number of ion channels, transporters and pores. However the physiological role of mitochondrial channels is largely unknown. The main channel of the outer membrane is VDAC, a well described anion conductance. In the inner membrane most prominent are the permeability transition pore (PTP) and the inner membrane anion channel IMAC. Different potassium channels are described as well (mitoBK, mitoKATP and Kv1.3) and a number of calcium conducting channels and receptors (for example MCU). To study the channels of the inner mitochondrial membrane the outer membrane can be stripped of by osmotic swelling. This method was used for the examples of electrophysiological measurement with the Port-a-Patch shown below. 

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