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    Nanion技术: 离子通道研究的智能工具

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    SURFE²R 96SE: 非标记高通量转运体筛选

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    Dynamic Clamp: Patchliner

  • 脂双层记录: Orbit产品系列

    脂双层记录: Orbit产品系列

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    CardioExcyte 96 SOL:用光遗传的手段起搏心肌细胞

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CardioExcyte 96

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Orbit 16

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Orbit Mini

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Vesicle Prep Pro

Mitochondria - "Recordings from mitochondria and mitoplasts"

icon pap   Port-a-Patch application note   logo pdf   (0.4 MB)

Summary:

Mitochondria are often referred to as the “power house” of the cell since they are responsible for making most of the cell’s energy supply in the form of adenosine triphosphate (ATP). In addition to providing the cell with energy, mitochondria are thought to have roles in cell signalling, cellular differentiation and apoptosis. They have also been implicated in the pathophysiology of neurodegenerative disorders such as Parkinson’s Disease , and may also play a role in diabetes and in the ageing process. Mitochondria are usually rod shaped and range in size from approximately 1 - 10 µm. They have an outer membrane and a highly folded inner membrane. The outer membrane is highly permeable and contains one of the most well studied mitochondrial proteins, the voltage-dependent anion channel (VDAC). The inner membrane contains many ion channels, including the Ca2+ uniporter, a KATP channel, the Ca2+-activated K+ channel (KCa) and the inner membrane anion channel (IMAC). To study the mitochondrial inner membrane using the patch clamp technique, mitoplasts were formed. This is a process whereby the mitochondria are swelled, thus rupturing the outer membrane and exposing the inner membrane.

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