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    Nanion技术: 离子通道研究的智能工具

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    SyncroPatch 384i: HTS Automated Patch Clamp

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    SURFE²R 96SE: 非标记高通量转运体筛选

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    Dynamic Clamp: Patchliner

  • 脂双层记录: Orbit产品系列

    脂双层记录: Orbit产品系列

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    CardioExcyte 96 SOL:用光遗传的手段起搏心肌细胞

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CardioExcyte 96

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Vesicle Prep Pro

TRPM8 / TRPV1 - "TRPV1 and TRPM8 recorded on Nanion's Port-a-Patch"

icon pap   Port-a-Patch application note:  logo pdf   (0.2 MB)

Summary:

TRPV1 and TRPM8 are members of the transient receptor potential channel (TRP) family. This family was designated TRP because of a spontaneously occurring Drosophila mutant lacking TRP that responded to a continuous light with a transient receptor potential. TRPV1 is mainly expressed in sensory nerves. Its presence is essential for transduction of nociception as well as inflammatory and hypothermic effects of vanniloid compounds. It also contributes to acute thermal nociception and thermal hyperalgesia following tissue injury. TRPV1 forms a relatively Ca2+-selective ion channel with outwardly rectifying properties. It is activated by vanilloids such as capsaicin, by protons, increased temperatures, lipoxygenase products, as well as anandamide (Huang et al., 2002). Menthol, a secondary alcohol produced by the peppermint herb, Mentha piperita, is widely used in the food and pharmaceutical industries as a cooling/soothing compound and odorant. It induces Ca2+ influx in a subset of sensory neurons from dorsal root and trigeminal ganglia, due to activation of TRPM8, a Ca2+-permeable, cold-activated member of the TRP superfamily of cation channels (McKemy et al., 2002; Peier et al., 2002). Here we present data of TRPV1 and TRPM8 collected on the Port-a-Patch. Channel activation with capsaicin as well as menthol are shown.

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