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  • 脂双层记录: Orbit产品系列

    脂双层记录: Orbit产品系列

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    CardioExcyte 96 SOL:用光遗传的手段起搏心肌细胞

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2003 - Lighting up single ion channels

icon pap  Port-a-Patch publication in Biophysical Journal (2003)

Authors: 
Selvin P.R.

 

Journal: 
Biophys. J. (2003) 84:1-2


Abstract: 

The holy grail of ion channel studies is to produce an atomic scale movie of an ion channel at work, simultaneously observing conformational and electrical changes as ions flow through the protein. Significant milestones toward this goal include the x-ray crystallography work of Mackinnon et al., which gave us atomic-resolution snapshots of potassium (Zhou et al., 2001) and chloride channels (Dutzler et al., 2002), and patch clamping, which revolutionized the field by giving us the ability to measure ionic currents through single ion channels.


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