• Nanion技术: 离子通道研究的智能工具

    Nanion技术: 离子通道研究的智能工具

  • SyncroPatch 384i: HTS Automated Patch Clamp

    SyncroPatch 384i: HTS Automated Patch Clamp

  • SURFE²R 96SE: 非标记高通量转运体筛选

    SURFE²R 96SE: 非标记高通量转运体筛选

  • Dynamic Clamp: Patchliner

    Dynamic Clamp: Patchliner

  • 脂双层记录: Orbit产品系列

    脂双层记录: Orbit产品系列

  • CardioExcyte 96 SOL:用光遗传的手段起搏心肌细胞

    CardioExcyte 96 SOL:用光遗传的手段起搏心肌细胞

我们的产品目录

SyncroPatch 384i

SyncroPatch 384i

Patchliner

Patchliner

Port-a-Patch

Port-a-Patch

Port-a-Patch mini

Port-a-Patch mini

CardioExcyte 96

CardioExcyte 96

FLEXcyte 96

FLEXcyte 96

SURFE²R 96SE

SURFE²R 96SE

SURFE²R N1

SURFE²R N1

Orbit 16

Orbit 16

Orbit Mini

Orbit Mini

Vesicle Prep Pro

Vesicle Prep Pro

2018 - Simplifying artificial bilayer experiments: Single-molecule experiments on micro-cavity arrays

Icon Orbit   Orbit 16 and   Icon Orbit Mini   Orbit mini Oral Presentation

Presenter: 
Dr. Conrad Weichbrodt, Product Manager Orbit instrument family, Nanion Technologies GmbH, Germany
Source:
Webinar: "Artificial Lipid Bilayers in focus: Hand-held DNA-sequencing and biosensing with nanopores", June 28, 2018

Title:
Simplifying artificial bilayer experiments: Single-molecule experiments on micro-cavity arrays

Abstract:
Artificial lipid bilayers represent the gold standard for the investigation of membrane spanning species like purified ion channels or membrane-active species in general like toxins. However, the convenient and reproducible preparation of these model bilayers as well as the delicate successive handling for data acquisition still remain an obstacle for the trouble-free introduction of this technique. We here present Nanion’s Orbit systems that are explicitly designed to meet the special requirements of experiments on artificial bilayers. Use of Ionera’s MECA (micro electrode cavity array) chip technology combined with state of the art low noise amplifiers (Elements S.R.L.) enables the fully parallel low-noise recording of four or even 16 separate lipid bilayers at bandwidths up to 100 kHz. The systems have already been validated with targets as diverse as ligand and voltage gated ion channels, porins and origami DNA constructs, antimicrobial peptides or membrane active toxins. The optional temperature control for the Orbit mini furthermore allows for experiments on temperature sensitive species such as TRP channels or for experiments at physiological temperatures whereas the fully automated bilayer generation on the Orbit e16 further improves the system’s usability

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