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2020 - Mechanobiology of in vitro assays: Tackling prevailing challanges in pre-clinical drug development

Icon FLEX    FLEXcyte 96 presentation (slide deck)  logo pdf (1.5 MB)

Presenter:
Dr. Matthias Gossmann
co-founder and CEO at InnoVitro, Germany

Source:
The 64th Annual Meeting of the Biophysical Society, San Diego, CA (USA)
Feb 15-19. 2020

Abstract:
Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. Integration into standard lab procedures remains a challenge for current in vitro systems. The FLEXcyte 96 system has the potential to scale-up mechanical testing towards medium-throughput analyses. We show here that, using stem cell-derived cardiomyocytes, this system enables predictive recordings of contractile behaviour in the presence of well-known reference compounds.

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