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2020 - Wireless Charging Electrochemiluminescence System for Ionic Channel Manipulation in Living Cells

icon pap   Port-a-Patch publication in ACS Applied Materials & Interfaces (2020)

Authors:
Peng K., Liu S., Lv F., Fu X., Hussain S., Zhao H., Liu L., Wang S.

Journal:
ACS Applied Materials & Interfaces (2020) 12 (22), 24655-24661 doi: 10.1021/acsami.0c07476


Abstract:

Optogenetics holds great potential for precisely altering living cell behavior with the aid of light because of its high temporospatial resolution. However, the light-dependent manner severely limits its applications in deep tissues, particularly to those in the visible region. Here, we propose a wireless charging electrochemiluminescence (ECL) system, featured with long-time delayed luminescence, to remotely activate the light-gated ion channel (channelrhodopsin-2, ChR2) on the living cell membrane, followed by the intracellular influx of Ca2+ ions. Upon wireless charging ECL illumination, the influx of Ca2+ into the living cells triggers strong ion indicator fluorescence, suggesting the successful remote control on ChR2. As such, the wireless charging ECL strategy exhibits great potential to wireless control of optogenetics in deep tissues by implanting a device in vivo.


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