2021 - Drug Effects on human Na+/Ca2+ Exchanger and Implications for Drug Development
FLEXcyte 96 and SURFE²R N1 and SURFE²R 96SE poster, Biophysical Society Meeting 2021 (1.3 MB)
The Na+/Ca2+-exchanger (NCX) plays an important role in cellular calcium homeostasis under physiological but also pathological conditions. The pharmacological potential and risks of NCX have been debated for many years. The consequences of changes in activity and mode of operation of NCX are still discussed. Mostly a potential beneficial effect of NCX reverse mode inhibition under ischemic conditions has been suggested. There is ongoing effort to find specific and direction-specific NCX inhibitors, but inadvertent NCX inhibition is usually not tested during drug development.