• Nanion技术: 离子通道研究的智能工具

    Nanion技术: 离子通道研究的智能工具

  • SyncroPatch 384i: HTS Automated Patch Clamp

    SyncroPatch 384i: HTS Automated Patch Clamp

  • SURFE²R 96SE: 非标记高通量转运体筛选

    SURFE²R 96SE: 非标记高通量转运体筛选

  • Dynamic Clamp: Patchliner

    Dynamic Clamp: Patchliner

  • 脂双层记录: Orbit产品系列

    脂双层记录: Orbit产品系列

  • CardioExcyte 96 SOL:用光遗传的手段起搏心肌细胞

    CardioExcyte 96 SOL:用光遗传的手段起搏心肌细胞

我们的产品目录

SyncroPatch 384

SyncroPatch 384

Patchliner

Patchliner

Port-a-Patch

Port-a-Patch

Port-a-Patch mini

Port-a-Patch mini

CardioExcyte 96

CardioExcyte 96

FLEXcyte 96

FLEXcyte 96

SURFE²R 96SE

SURFE²R 96SE

SURFE²R N1

SURFE²R N1

Orbit 16 TC

Orbit 16 TC

Orbit Mini

Orbit Mini

Vesicle Prep Pro

Vesicle Prep Pro

11.03.2021 | Webinar: automated patch clamp webinar high throughput functional evaluation of melanocortin and a CiPA based evaluation of proarrhythmic risk

icon sp96  SyncroPatch 384i 

Date: March 11. 2021

210311 SP384 March 11 Webinar CRL UMich V1

Speakers:

Ciria Hernandez, MD, Ph.D
(Assistant Research Scientist  - University of Michigan Life Sciences Institute)

Yuri Kuryshev
(Principal Scientist - Charles River Laboratories)



Presenter: Ciria Hernandez, MD, Ph.D

Title: 
High-Throughput Functional Evaluation of Melanocortin Compounds at the MC4R-Kir7.1 Complex: Biased Signaling at the Melanocortin 4 Receptor

Abstract: 

Melanocortin 4 receptors (MC4R) are G-protein coupled receptors (GPCR) that mediate a variety of physiological processes critical for energy homeostasis. Loss-of-function MC4R mutations are linked to early-onset syndromic obesity. MC4R is the first GPCR reported to functionally directly interact with the inward rectifier potassium channel Kir7.1. In the paraventricular nucleus of the hypothalamus, MC4R activation leads to Kir7.1 closure causing neuronal depolarization and satiety, whereas its inhibition promotes channel opening leading to membrane hyperpolarization and hunger. The discovery of a G-protein independent pathway for MC4R signaling through Kir7.1 opened new venues for the exploration of new signaling pathways by GPCRs."


Presenter: Yuri Kuryshev

Title: 
CiPA Based Evaluation of Proarrhythmic Risk Using the SyncroPatch 384PE

Abstract:

Cardiac arrhythmias are a limiting factor for development of new drugs in any therapeutic area. Proarrhythmic risk prediction modeling is a contemporary approach for cardiac safety and the modeling requires reliable experimental data for drug effects on four major cardiac ion channel currents – hERG, Cav1.2 (peak and late) and Nav1.5 (late). We have validated these channel assays on SyncroPatch 384PE platform and applied them to evaluation several drugs with questionable proarrhythmic safety.



Q&A File Here (upcoming)

返回总览

 

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.