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07.09.2021 | Webinar: Automated patch clamp assay development for the study of red blood cells (RBCs) in health and disease

icon sp96   SyncroPatch 384,   icon pl   Patchliner,   icon pap   Port-a-Patch Webinar

Date: September 07. 2021, 4:00 PM CEST (10:00 AM EDT)

Abstract:

Calcium (Ca2+) is a universal signalling molecule and is critically important in regulating many physiological functions and survival of RBCs. Amongst others, intracellular Ca2+ controls cell volume and deformability. This process plays a substantial role in RBCs since their volume needs to adapt when passing blood vessel constrictions during the flow. Excessive Ca2+ uptake also leads to accelerated cell clearance causing anaemia.

Therefore, studying Ca2+ regulation is crucial to understand RBC diseases. Piezo1, KCa3.1 (Gardos channel) and NMDA receptors are three channels present in the RBC membrane and critical for Ca2+ regulation.

We developed functional assays to measure these channels in healthy and diseased RBCs populations using electrophysiological tools, contributing to the characterization of RBC diseases.

Presenters: 

Nicoletta Murciano
(PhD Candidate - Nanion Technologies )

Title: 
Automated patch clamp assay development for the study of red blood cells (RBCs) in health and disease

Dr. Lars Kaestner
(Professor - Saarland University)

Title: 
Introduction to EVIDENCE prognostic, diagnostic, and therapeutic approaches on RBC function in health and disease


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