2022 - Hypoglycemia-Exacerbated Mitochondrial Connexin 43 Accumulation Aggravates Cardiac Dysfunction in Diabetic Cardiomyopathy
CardioExcyte 96 prepublication in Frontiers in Cardiovascular Medicine (2022)
Wei X., Chang A.C.H., Chang H., Xu S., Xue Y., Zhang Y., Lei M., Chang A.C.Y., Zhang Q.
Frontiers in Cardiovascular Medicine (2022) doi: 10.3389/fcvm.2022.800185
Diabetic cardiomyopathy (DCM) is a complex multifaceted disease responsible for elevated heart failure (HF) morbidity and mortality in patients with diabetes mellitus (DM). Patients with DCM exhibit subclinical diastolic dysfunction, progression toward systolic impairment, and abnormal electrophysiology. Hypoglycemia events that occur spontaneously or due to excess insulin administration threaten the lives of patients with DM—with the increased risk of sudden death. However, the molecular underpinnings of this fatal disease remain to be elucidated.