Bestrophin-1 | BEST1
Family:
Calcium-dependent chloride channels (Ca-CIC or CaCC family)
Members:
CaCCs that are known to occur in humans are encoded by the following genes:
Accessories: CLCA1 - CLCA4
Anoctamins: ANO-1 and ANO-2
Bestrophins: BEST1 - BEST4
Topology:
CaCC channels are a heterogeneous groups of ligand-gated ion channels for chloride that have been identified in many epithelial and endothelial cell types as well as in smooth muscle cells, including proteins from several structurally different families: chloride channel accessory (CLCA), bestrophin (BEST), and calcium-dependent chloride channel anoctamin (ANO or TMEM16) channels. Members of the Ca-CIC family exhibit 7 to 10 transmembrane segments.
Publications
2018 - An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1
Port-a-Patch publication in Journal of General Physiology (2018)
Authors:
Vaisey G., Long S.B.
2016 - Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel
Port-a-Patch publication in Proceedings of the National Academy of Sciences of the United States of America (2016)
Authors:
Vaisey G., Miller A.N., Long S.B.