FoF1 - ATP phosphohydrolase (H+-Transporting) - ATP-Synthase
F-type ATPases, members belong to the P-bond hydrolysis driven transporters superfamily
The F1 motor, responsible for ATP turnover, has the subunit composition α3β3γδε.The F0 motor, responsible for ion translocation, is complex in mammals, with probably nine subunits centring on A, B, and C subunits in the membrane, together with D, E, F2, F6, G2 and 8 subunits. Multiple pseudogenes for the F0 motor proteins have been defined in the human genome.
F-type ATPases are found in eukaryotic mitochondria and chloroplasts as well as in bacteria. The F-type ATPase in humans is a mitochondrial membrane-associated multimeric complex consisting of two domains, an F0 channel domain in the membrane and an F1 domain extending into the lumen. Proton transport across the inner mitochondrial membrane is used to drive the synthesis of ATP, although it is also possible for the enzyme to function as an ATPase.