• GABAA a1b2g2

    Concentration dependent activation and desensitization of GABAA (α1β2γ2) receptors by application of 1, 3 and 10 μM GABA as measured on the Port-a-Patch)

GABAA receptors - Investigation of Modulators

p37 1 modulatorsicon pl   Patchliner data and applications:
Cells were kindly provided by AstraZeneca.

The top images show dose dependent block of GABAA currents by bicuculline. The IC50 was determined as 1.2 ± 0.2 μM (n=11). The lower graph shows the positive modulation of glycine activation of hGlyRα1. Here, six co-applications of 20 μM glycine and increasing concentrations of a positive modulator are shown.

 

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