• GABAA a5b3g2

    Pharmacology on GABAA α5β3γ2 as recorded on the SyncroPatch 96, a predecessor model of the SyncroPatch 384PE

GABAA Receptor (a5b3g2) - Antagonists

GABAa5 Antagonists small

icon sp96   SyncroPatch 96 (a predecessor model of SyncroPatch 384PE) data and applications:
Cells were kindly provided by Millipore.

Mean concentration response curves for Bicuculline, IC50 = 327 nM (n = 14); for a5IA IC50 = 933 pM (n = 11),  maximum block was 45% at 100 nM; for FG7142 IC50= 2.5 mM (n = 9), maximum block was 64.3% at 10 μM; for MRK016 maximum current inhibition was 52% at 1uM, IC50= 1.02 nM (n = 15).




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