• GABAA a5b3g2

    Pharmacology on GABAA α5β3γ2 as recorded on the SyncroPatch 96, a predecessor model of the SyncroPatch 384PE

GABAA receptors - Investigation of Modulators

p37 1 modulatorsicon pl   Patchliner data and applications:
Cells were kindly provided by AstraZeneca.

The top images show dose dependent block of GABAA currents by bicuculline. The IC50 was determined as 1.2 ± 0.2 μM (n=11). The lower graph shows the positive modulation of glycine activation of hGlyRα1. Here, six co-applications of 20 μM glycine and increasing concentrations of a positive modulator are shown.

 

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